A5044510730- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Cancer Treatment and Pharmacology
- Colorectal Cancer Surgical Treatments
- Cancer, Lipids, and Metabolism
- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
- Diagnosis and treatment of tuberculosis
- Computational Drug Discovery Methods
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Metabolomics and Mass Spectrometry Studies
- Neutropenia and Cancer Infections
- Nutritional Studies and Diet
- Advanced Breast Cancer Therapies
- Advanced X-ray and CT Imaging
Guangdong Academy of Medical Sciences
2023-2024
Southern Medical University
2023-2024
Guangdong Provincial People's Hospital
2023-2024
Key Laboratory of Guangdong Province
2023-2024
Background: Tumor-stroma interactions, as indicated by tumor-stroma ratio (TSR), offer valuable prognostic stratification information. Current histological assessment of TSR is limited tissue accessibility and spatial heterogeneity. We aimed to develop a multitask deep learning (MDL) model noninvasively predict prognosis in colorectal cancer (CRC). Materials Methods: In this retrospective study including 2268 patients with resected CRC recruited from four centers, we developed an MDL using...
Desmoplastic reaction (DR) is one of many tumor-host interactions and associated with the overall survival (OS) patients colorectal cancer. However, clinical significance DR requires further study in large multicenter cohorts its predictive value adjuvant chemotherapy (ACT) response remains unclear. Here, a total 2,225 cancer from five independent institutions were divided into primary (N = 1,012 two centers) validation 1,213 three cohorts. was classified as immature, middle, or mature...
<p>Correlation between DR and DFS</p>
<p>Histological features of the desmoplastic reaction</p>
<p>Predictive significance of other MSI status on the ACT stage II CRC</p>
<p>Prognostic significance of DR categorization in different subgroups CRC patients</p>
<p>Correlation between DR and T status, N status</p>
<p>Histological features of the desmoplastic reaction</p>
<p>Predictive significance of other MSI status on the ACT stage II CRC</p>
<p>Prognostic significance of DR categorization in each TNM stages CRC patients</p>
<div>Abstract<p>Desmoplastic reaction (DR) is one of many tumor-host interactions and associated with the overall survival (OS) patients colorectal cancer (CRC). However, clinical significance DR requires further study in large multicenter cohorts its predictive value adjuvant chemotherapy (ACT) response remains unclear. Here, a total 2225 CRC from five independent institutions were divided into primary (N=1012 two centers) validation (N=1213 three cohorts. classified as...
<p>Predictive significance of other TB on the ACT stage II CRC</p>
<p>Nomogram for OS and boxplots of C-indices in primary validation cohorts</p>
<div><p>Desmoplastic reaction (DR) is one of many tumor–host interactions and associated with the overall survival (OS) patients colorectal cancer. However, clinical significance DR requires further study in large multicenter cohorts its predictive value adjuvant chemotherapy (ACT) response remains unclear. Here, a total 2,225 cancer from five independent institutions were divided into primary (<i>N</i> = 1,012 two centers) validation 1,213 three cohorts. was...
<p>Nomogram for OS and boxplots of C-indices in primary validation cohorts</p>
<p>Correlation between DR and DFS</p>