A5037702686- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Innovations in Medical Education
- Inhalation and Respiratory Drug Delivery
- Clinical Reasoning and Diagnostic Skills
- COVID-19 Clinical Research Studies
- Empathy and Medical Education
- Fatty Acid Research and Health
- Sepsis Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Hemoglobin structure and function
- Child and Adolescent Health
- Patient-Provider Communication in Healthcare
- Respiratory Support and Mechanisms
- Healthcare Systems and Technology
- Electronic Health Records Systems
- Infant Nutrition and Health
- Glycosylation and Glycoproteins Research
- Neonatal Health and Biochemistry
- Growth Hormone and Insulin-like Growth Factors
- Primary Care and Health Outcomes
- Medical Malpractice and Liability Issues
- Environmental Chemistry and Analysis
- Machine Learning in Healthcare
- Congenital Diaphragmatic Hernia Studies
University of Minnesota System
2020-2024
University of Minnesota
2012-2024
Fairview Health Services
2021-2024
Association of Research Libraries
2023
University of Minnesota Medical Center
1991-2022
Jacobs (United States)
2022
North Carolina State University
2020-2021
University of Florida
2020-2021
Dartmouth Hospital
2020-2021
Dartmouth College
2020-2021
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffects of a surfactant-associated protein and calcium ions on the structure surface activity lung surfactant lipidsSamuel Hawgood, Bradley J. Benson, Robert L. Hamilton, Jr.Cite this: Biochemistry 1985, 24, 1, 184–190Publication Date (Print):January 1985Publication History Published online1 May 2002Published inissue 1 January 1985https://pubs.acs.org/doi/10.1021/bi00322a026https://doi.org/10.1021/bi00322a026research-articleACS PublicationsRequest...
The Accreditation Council for Graduate Medical Education Outcome Project has shifted the focus of residents' education to competency-based outcomes learning. challenge meaningful assessment learner competence stimulated interest in Dreyfus and Model, a framework assessing skill acquisition that describes developmental stages beginning with novice progressing through advanced beginner, competent, proficient, expert, master. Many educators have adopted this model, but no consensus about its...
SP 28-36, a major protein of pulmonary surfactant, has striking amino acid sequence homology with soluble mannose-binding proteins isolated from rat liver and contains residues common to the carbohydrate-binding domains other mammalian lectins. We have used carbohydrate-affinity chromatography investigate properties 28-36 canine human (alveolar proteinosis patients) lung lavage. binds immobilized D-mannose, L-fucose, D-galactose, D-glucose. The only weakly N-acetyl-D-galactosamine N...
The pulmonary surfactant proteins SP-B (8,000 D) and SP-C (4,000 accelerate surface film formation by phospholipids. We used cDNA probes to examine regulation of these in human fetal lung. mRNAs were detectable at 13 wk gestation increased approximately 50% (SP-B) 15% (SP-C) adult levels 24 wk. detected only lung 11 dog tissues examined. When was cultured as explants without hormones, mRNA decreased. Exposure for 48 h glucocorticoids, but not other steroids, both (approximately 4-fold)...
The apoproteins of pulmonary surfactant (PSAP) are thought to be critical for normal function. They bind phospholipids and enhance their ability form surface films in vitro. These acidic glycoproteins have monomeric molecular weights 36,000, 32,000, 28,000 (PSAP-36, -32, -28). Each member this family proteins has a similar amino acid composition differences electrophoretic mobility due part glycosylation. We derived the full sequence PSAP-32 from nucleotide PSAP cDNA. A cDNA library was...
Abstract Background The Accreditation Council for Graduate Medical Education (ACGME) and the American Board of Pediatrics (ABP) have partnered to initiate Milestone Project further refine 6 ACGME competencies set performance standards as part continued commitment document outcomes training program effectiveness. Intervention Members Working Group searched medical literature beyond create a synopsis models evidence developmental ontogeny elements 52 subcompetencies. For each subcompetency, we...
Background Type 2 diabetes (T2DM) and obesity are significant risks for mortality in Covid19. Metformin has been hypothesized as a treatment COVID19. sex specific immunomodulatory effects which may elucidate mechanisms COVID-19. In this study we sought to identify whether metformin reduced from Covid19 if interactions exist. Methods De-identified claims data UnitedHealth were used persons with at least 6 months continuous coverage who hospitalized Covid-19. Persons the group had 90 days of...
Heterogeneity has been observed in outcomes of hospitalized patients with coronavirus disease 2019 (COVID-19). Identification clinical phenotypes may facilitate tailored therapy and improve outcomes. The purpose this study is to identify specific across COVID-19 compare admission characteristics
Pulmonary surfactant stabilizes lung alveoli, preventing respiratory failure and hyaline membrane disease in premature infants. In addition to lipids, contains apoproteins that are thought be critical for normal function. We have examined the ontogeny regulation of major surfactant-associated protein molecular mass 28-36 kDa (SP 28-36) human fetal lung. SP was not detected tissue from second trimester abortuses by either immunoblot analysis or enzyme-linked immunosorbent assay (less than...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBinding of calcium to SP-A, a surfactant-associated proteinHenk P. Haagsman, Tania Sargeant, Peter V. Hauschka, Bradley J. Benson, and Samuel HawgoodCite this: Biochemistry 1990, 29, 38, 8894–8900Publication Date (Print):September 25, 1990Publication History Published online1 May 2002Published inissue 25 September 1990https://doi.org/10.1021/bi00490a003RIGHTS & PERMISSIONSArticle Views107Altmetric-Citations62LEARN ABOUT THESE METRICSArticle Views...
Abstract In the September 2010 issue of JGME, Pediatric Milestones Working Group published “The Pediatrics Milestones: Conceptual Framework, Guiding Principles, and Approach to Development”, a document that describes construction first iteration Milestones. These were developed by as group practical behavioral expectations for each 52 sub-competencies. constructing these Milestones, authors cognizant need ground themselves in evidence, theories or other conceptual frameworks would provide...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLung surfactant proteins, SP-B and SP-C, alter the thermodynamic properties of phospholipid membranes: a differential calorimetry studyKathleen Shiffer, Samuel Hawgood, Henk P. Haagsman, Bradley Benson, John A. Clements, Jon GoerkeCite this: Biochemistry 1993, 32, 2, 590–597Publication Date (Print):January 19, 1993Publication History Published online1 May 2002Published inissue 19 January...
Pulmonary surface active material (SAM), purified from canine lung lavage fluids, is a phospholipid-rich lipoprotein with potent immunosuppressive activity. Experiments were performed to identify those components of SAM that responsible for this effect. Results indicated the lipid, and not protein, fraction was immunosuppressive. Two phospholipids, phosphatidylglycerol phosphatidylcholine, identified as predominant SAM-lipid fraction. lymphocyte proliferation in response mitogenic or...