A5076267878- Bacteriophages and microbial interactions
- Herpesvirus Infections and Treatments
- Prion Diseases and Protein Misfolding
- RNA and protein synthesis mechanisms
- Evolution and Genetic Dynamics
- Alzheimer's disease research and treatments
- Cytomegalovirus and herpesvirus research
- Quantum Dots Synthesis And Properties
- Genomics and Phylogenetic Studies
- Cancer Genomics and Diagnostics
- Virus-based gene therapy research
- Plant Virus Research Studies
- Graph theory and applications
- Calcium Carbonate Crystallization and Inhibition
- RNA modifications and cancer
- Telomeres, Telomerase, and Senescence
- Diatoms and Algae Research
- Zoonotic diseases and public health
- Genomics and Rare Diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Yersinia bacterium, plague, ectoparasites research
- RNA regulation and disease
- Animal Virus Infections Studies
Freie Universität Berlin
2017-2020
Max Delbrück Center
2018-2020
Codon pair deoptimization is an efficient virus attenuation strategy, but the mechanism that leads to unknown. The strategy involves synthetic recoding of viral genomes alters positions synonymous codons, thereby increasing number suboptimal codon pairs and CpG dinucleotides in recoded genomes. Here we identify molecular deoptimization-based by studying influenza A viruses. We show cause attenuation, whereas increase has no effect. Furthermore, reduce both mRNA stability translation...
Abstract Virulence determines the impact a pathogen has on fitness of its host, yet current understanding evolutionary origins and causes virulence many pathogens is surprisingly incomplete. Here, we explore evolution Marek's disease virus ( MDV ), herpesvirus commonly afflicting chickens rarely other avian species. The history in 20th century represents an important case study virulence. severity infection been rising steadily since adoption intensive farming techniques vaccination programs...
Dispersions of small TiO2 nanoparticles in alcohol, stabilized by surface complexation with protonated triethanolamine ligands, are proposed as bio-encapsulation matrices. They were characterized TEM and EXAFS spectroscopy, DLS was used to investigate the stability over time their pure form after insertion into aqueous medium. This study reveals unusual structural features that explain recently demonstrated facile formation dense encapsulates on biological objects. In view potentially broad...
The self-assembly of the 42-residue amyloid-β peptide, Aβ42, into fibrillar aggregates is associated with neuronal dysfunction and toxicity in Alzheimer's disease (AD) patient brains, suggesting that small molecules acting on this process might interfere pathogenesis. Here, we present experimental evidence molecule sclerotiorin (SCL), a natural product belonging to group azaphilones, potently delays both seeded nonseeded Aβ42 polymerization cell-free assays. Mechanistic biochemical studies...
Polar bears in captivity can be exposed to opportunistic pathogens not present their natural environments. A 4-month-old polar bear (Ursus maritimus) living an isolated enclosure with his mother the Tierpark Berlin, Germany, was suffering from severe abdominal pain, mild diarrhea, and loss of appetite died early 2017. Histopathology revealed hepatic degeneration necrosis without evidence inflammation or inclusion bodies, although a viral infection had been suspected on basis clinical signs....
Detection of genetic variants in clinically relevant genomic hot-spot regions has become a promising application next-generation sequencing technology precision oncology. Effective personalized diagnostics requires the detection with often very low frequencies. This can be achieved by targeted, short-read that provides high depths. However, rare contain crucial information for early cancer and subsequent treatment success, an inevitable level background noise usually limits accuracy...