A5096680484- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neurotransmitter Receptor Influence on Behavior
University of Minho
2024-2025
The nucleus accumbens (NAc) is a key brain region for motivated behaviors, yet how distinct neuronal populations encode appetitive or aversive stimuli remains undetermined. Using microendoscopic calcium imaging in mice, we tracked NAc shell D1- D2-medium spiny neurons' (MSNs) activity during exposure to of opposing valence and associative learning. Despite drift individual coding, both D2-population was sufficient discriminate unconditioned stimuli, but not predictive cues. Notably, D2-MSNs...
The mesopontine tegmentum, comprising the pedunculopontine tegmentum (PPN) and laterodorsal (LDT), is intricately connected to various regions of basal ganglia, motor systems, limbic systems. PPN LDT can regulate activity different brain these target in this way are a privileged position modulate motivated behaviours. Despite recent findings, have been largely overlooked discussions about neural circuits associated with reward aversion. This review aims provide timely comprehensive resource...