A5049777950- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Cancer Genomics and Diagnostics
- Chromosomal and Genetic Variations
- Neonatal Respiratory Health Research
- Chemokine receptors and signaling
- RNA Research and Splicing
- Tuberous Sclerosis Complex Research
- Glycosylation and Glycoproteins Research
- Renal and related cancers
- Cancer therapeutics and mechanisms
- Malaria Research and Control
- CAR-T cell therapy research
- Congenital Diaphragmatic Hernia Studies
- Pharmaceutical Practices and Patient Outcomes
- Eosinophilic Disorders and Syndromes
- RNA modifications and cancer
- Pharmacovigilance and Adverse Drug Reactions
- Signaling Pathways in Disease
- vaccines and immunoinformatics approaches
- Currency Recognition and Detection
- Pharmaceutical Quality and Counterfeiting
- Complementary and Alternative Medicine Studies
- Cancer-related molecular mechanisms research
Indiana University Health
2021-2025
Indiana University – Purdue University Indianapolis
2021-2025
Indiana University Indianapolis
2021-2025
Indiana University School of Medicine
2022-2024
Indiana University
2022
Cincinnati Children's Hospital Medical Center
2018-2021
University of Indianapolis
2021
Perinatal Institute
2019-2020
University of Cincinnati
2018
Kerala Agricultural University
2013
The respiratory system undergoes a diversity of structural, biochemical, and functional changes necessary for adaptation to air breathing at birth. To identify the heterogeneity pulmonary cell types dynamic in gene expression mediating respiration, here we perform single RNA analyses mouse lung on postnatal day 1. Using an iterative type identification strategy unbiasedly murine types. We distinct populations epithelial, endothelial, mesenchymal, immune cells, each containing subpopulations....
Rationale: Lymphangioleiomyomatosis (LAM) is a metastatic neoplasm of reproductive-age women associated with mutations in tuberous sclerosis complex genes. LAM causes cystic remodeling the lung and progressive respiratory failure. The sources cellular characteristics cells underlying disease pathogenesis remain elusive.Objectives: Identification characterization human uterus using single-cell approach.Methods: Single-cell single-nuclei RNA sequencing on (n = 4) control 7) lungs,...
While antenatal glucocorticoids are widely used to enhance lung function in preterm infants, cellular and molecular mechanisms by which glucocorticoid receptor (GR) signaling influences maturation remain poorly understood. Deletion of the gene (Nr3c1) from fetal pulmonary mesenchymal cells phenocopied defects caused global Nr3c1 deletion, while epithelial- or endothelial-specific deletion did not impair at birth. We integrated genome-wide expression profiling, ATAC-seq, single cell RNA-seq...
Multiple Myeloma is an incurable plasma cell malignancy with a poor survival rate that usually treated immunomodulatory drugs (iMiDs) and proteosome inhibitors (PIs). The malignant cells quickly become resistant to these agents causing relapse uncontrolled growth of clones. From whole genome sequencing (WGS) RNA (RNA-seq) studies, different high-risk translocation, copy number, mutational, transcriptional markers can be identified. One markers, PHF19, epigenetically regulates cycle other...
Immunotherapy is now standard of care for multiple myeloma, where the most common targets are B cell maturation antigen, CD38, and G protein-coupled receptor class C group 5 member D but strategies to identify additional needed. We have utilized two large datasets genomic data integrated them with existing databases expressed surface in myeloma patients. Importantly, we also specific defined subgroups patients including primary translocations high-risk subgroups. Examples subgroup include...
Abstract A key treatment for patients with multiple myeloma is high-dose melphalan followed by autologous stem cell transplant (ASCT). It can provide a deep response long-term remission. However, some progress quickly, and it not clear why that is. Here, we performed single-cell RNA T-cell receptor (TCR) sequencing of the immune microenvironment 40 before after ASCT to determine if differences in composition could define those who would progress. Clear populations were identified...
Abstract Purpose: We designed a comprehensive multiple myeloma targeted sequencing panel to identify common genomic abnormalities in single assay and validated it against known standards. Experimental Design: The comprised 228 genes/exons for mutations, 6 regions translocations, 56 copy number (CNA). Toward validation, was conducted on 233 patient samples further using clinical FISH (translocations), multiplex ligation probe analysis (MLPA; CNAs), whole-genome (WGS; CNAs, translocations), or...
ABSTRACT The Mucocele or Mucus retention phenomenon is a salivary gland lesion of traumatic origin, formed when the main duct minor torn with subsequent extravasation mucus into fibrous connective tissue so that cyst like cavity produced. wall this by compressed bundles collagen fibrils and it filled mucin. Mucoceles are known to occur most commonly on lower lip, followed floor mouth buccal mucosa being next frequent sites. This paper reviews presents two case reports.
Alternative splicing plays a pivotal role in tumorigenesis and proliferation. However, its pattern pathogenic has not been systematically analyzed multiple myeloma or subtypes. profiles for 598 newly diagnosed patients with comprehensive genomic annotation identified primary translocations, 1q amplification, DIS3 events to have more differentially spliced than those without. Splicing levels were correlated expression of factors. Moreover, the non-homologous end joining pathway was an...
Biallelic TP53 inactivation is the most important high-risk factor associated with poor survival in multiple myeloma. Classical biallelic has been defined as simultaneous mutation and copy number loss studies; however, numerous studies have demonstrated that other factors could lead to of TP53. Here, we hypothesized novel inactivated samples existed myeloma population. A random forest regression model exploited an expression signature 16 differentially expressed genes between classical...
Medicinal plants and plant derived molecules are widely used in traditional cultures all over the world they becoming large popular among biomedical researchers pharmaceutical companies as a natural alternative to synthetic medicine. Information related medicinal herbal drugs accumulated ages scattered unstructured which make it prudent develop curated database for plants. The Antidiabetic Anticancer Plants Database (DIACAN) aims collect provide an integrated platform phytochemiclas having...
SUMMARY Lymphangioleiomyomatosis (LAM) is a metastasizing neoplasm of reproductive age women that causes cystic lung remodeling and progressive respiratory failure. The source LAM cells invade the reasons targets have remained elusive. We employed single cell nuclei RNA sequencing on lesions within explanted lungs, known to contain smooth muscle like bearing mTOR activating mutations in TSC1 or TSC2, identified unique population were readily distinguished from those endogenous cells. CORE...
Abstract Introduction: Although multiple myeloma (MM) is considered incurable, immune-related therapies are emerging as promising approaches to prolong patient survival. Alternative splicing (AS) has been identified a mechanism causing therapy resistance CD19 CAR-T in B-cell malignancies, but no systematic evaluation made on the impact towards MM immunotherapy targets. Methods: Utilizing two datasets (MMRF N=852 and IU N=122), we selected high-confidence targets based high RNA expression...
This study aims to assess the effectiveness of structured teaching program on prevention cervical cancer among urban women in chikkabanavara, Bengaluru, Karnataka. Cervical is one most preventable forms cancer, yet remains a significant public health concern, especially developing regions. The employed pre-test and post-test design evaluate knowledge regarding before after intervention. A total 40 participants where were selected through random sampling.A questionnaire was used measure their...
Recognization of Cloth Pattern and Colour for Blind People - written by G. Siva Sankar Varma , Shirisha Kamishetti P. Sudha published on 2020/05/21 download full article with reference data citations