A5075946896- Surfactants and Colloidal Systems
- Supramolecular Chemistry and Complexes
- Hydrogels: synthesis, properties, applications
- Advancements in Transdermal Drug Delivery
- Advanced Polymer Synthesis and Characterization
- Supramolecular Self-Assembly in Materials
- Carbohydrate Chemistry and Synthesis
- Proteoglycans and glycosaminoglycans research
- Lipid Membrane Structure and Behavior
- Contact Dermatitis and Allergies
- Molecular Sensors and Ion Detection
- Actinomycetales infections and treatment
- Diabetes Management and Research
- Advanced Drug Delivery Systems
- Membrane Separation and Gas Transport
- Infectious Diseases and Mycology
- Luminescence and Fluorescent Materials
- Drug Solubulity and Delivery Systems
- Silicone and Siloxane Chemistry
- Dermatology and Skin Diseases
- Nanoparticle-Based Drug Delivery
- Advanced Algorithms and Applications
- Pharmaceutical studies and practices
- Dendrimers and Hyperbranched Polymers
- Thermodynamic properties of mixtures
Josai University
2015-2024
A xanthene derivative containing a borinate moiety emitted red fluorescence with high quantum yield. The interaction between the and sugar molecule induced change based on in HOMO-LUMO gap. response was pH-resistant wide range. In addition, catechol quenched through photoinduced electron transfer. polyol binding ability of dyes will pave way for new biological applications chemical sensors.
A pseudopolyrotaxane (PPRX) comprising 3-carboxy-5-nitrophenylboronic acid modified γ-cyclodextrin (NPBA-γ-CyD) and naphthalene polyethylene glycol (Naph-PEG) as a sugar-responsive supramolecular structure is prepared. The binding of sugar by the NPBA group induced disintegration Naph-PEG/NPBA-γ-CyD PPRX, allowing components to be dissolved. PPRX exhibited better sensitivity compared that based on 4-carboxyphenylboronic (PBA-γ-CyD). We have previously reported unique Naph-PEG/PBA-γ-CyD which...
Multiple daily subcutaneous injections (MDSIs) are mainly used for formulating an insulin therapy diabetic patients; however, they also cause insulin-derived amyloidosis (IDA) and lead to poor glycemic control. In addition, the continuous infusion system (CSII), precipitation frequently causes catheter occlusion and, if precipitate in formulations is amyloid, injection of insoluble amyloid into tissue leads IDA. The aim this study was conduct vitro experiments present a situation where...
A novel glucose (Glc)-responsive gel formed by worm-like micelles (WLMs) has the potential to provide a self-regulating insulin delivery system. We have prepared WLM system using 75 mM cetyltrimethylammonium bromide, phenylboronic acid, and water. At pH 9.4, this gel-like was highly viscous supported its own weight, dynamic viscoelasticity measurement indicated that it contained long entangled WLMs. The visual observation of gels include >6 Glc revealed these adopted sol-like appearance,...
Herein, we report anomalous glucose (Glc)-responsive gelation/solation in 3-aminophenylboronic acid-modified hyaluronic acid.
A self-healing hydrogel can be easily prepared at physiological pH by using phenylboronic acid-modified hyaluronic acid and salicylic acid.
Supramolecular structures were developed from phenylboronic acid-modified cyclodextrins (PBA-CyDs). The intermolecular interaction between the PBA moiety and CyD cavity was proved using two dimensional (2D)-NMR powder X-ray diffraction techniques. PBA-α-CyD formed a head-to-tail supramolecular polymer, whereas PBA-β-CyD head-to-head dimer. disintegrated in presence of sugars owing to resulting boronate sugar interactions.
We have designed a sugar-responsive pseudopolyrotaxane (PPRX) by combining phenylboronic acid-modified polyethylene glycol (PBA-PEG) and γ-cyclodextrin. Phenylboronic acid (PBA) was used as sugar-recognition motif in the PPRX because PBA reacts with diol portion of sugar molecule forms cyclic ester. When D-fructose or D-glucose added to suspension PPRX, disintegrated, depending on concentration sugars. Interestingly, catechol does not show response although has high affinity for PBA....
p-Boronophenylmethoxycarbonyl (BPmoc) is a protecting group for amines that removable by treatment with hydrogen peroxide (H2O2). We prepared BPmoc-modified insulin (BPmoc-Ins) and subcutaneously injected the formulation into diabetic rats. The results demonstrated BPmoc effectively sealed blood glucose (Glc)-lowering effects of Ins. Conversely, coinjection BPmoc-Ins Glc oxidase (GOx) resulted in reduced levels, indicating Ins was generated from through following reactions: oxidation...
Tacrolimus (TL) ointment is a topical treatment for atopic dermatitis, disease that exhibits various skin conditions. The effect of pathologies on the systemic absorption TL and related side effects remains unknown. This study aimed to investigate factors affecting cutaneous TL. We prepared models in hairless rats by tape stripping, injection prophlogistic material solution (PMS), continuous subcutaneous adrenaline (Adr) infusion. In vivo studies were conducted, with measurements...
We had previously confirmed a glucose-responsive decrease in the viscosity of cetyltrimethylammonium bromide (CTAB) and phenylboronic acid (PBA) wormlike micelle (WLM) systems. However, mechanisms formation WLMs with glucose addition have not been determined. In this study, we elucidated using 3-fluorophenylboronic (3FPBA) based on 11B NMR 19F analyses. The system 60 mM CTAB/60 3FPBA at pH 7.4 demonstrated high viscoelasticity, was by rheological characteristics. spectrum revealed that...
Phenylboronic acid (PBA) derivatives have attracted substantial attention owing to their unique character of forming dynamic covalent bonds with polyol compounds. Recent studies shown interactions between PBA and sugar chains on the cell surface; they interesting applications for sensors drug delivery systems. In this study, we prepared phenylboronic acid-modified insulin (PBA-Ins) evaluate its glucose-lowering activity adhesiveness. case intravenous injection, PBA-Ins showed longer than...
We report a novel smart micellar system utilising phenylboronic acid (PBA) derivative whose viscosity increases on adding diol compounds such as sugar or alcohol.
Previous studies have shown that reversible chemical bond formation between phenylboronic acid (PBA) and 1,3-diol can be utilized as the driving force for preparation of layer-by-layer (LbL) films. The LbL films composed a PBA-appended polymer poly(vinyl alcohol) (PVA) disintegrated in presence sugar. This type has been recognized promising approach sugar-responsive drug release systems, but an issue preventing practical application is combining them with insulin. In this report, we proposed...
We prepared polypseudorotaxanes (PPRXs) composed of cyclodextrin (CyD) and polyethylene glycol (PEG) inside microspheres (MSs) by an emulsifying process using polypropylene (PPG) that shows temperature-dependent hydrophilicity changes; PPG is hydrophobic at high temperatures but hydrophilic low temperatures. An aqueous solution CyD PEG was dispersed as droplets in 60°C then cooled to 0°C allow water transfer into PPG. On removal the droplets, were left behind a CyD/PEG PPRX solid-state MSs....
External stimuli-responsive worm-like micelles (WLMs) have the potential for a wide range of applications. In particular, sugar (a polyol compound)-responsive WLMs use in smartdrug release systems. Phenylboronic acid (PBA) functions as cis-diol sensor similar manner it does glucose sensor. Thus, WLMs, primarily composed surfactants and PBA, are expected to function cis-diol-responsive viscoelastic PBA also reacts irreversibly with hydrogen peroxide (H2O2 ) is converted into phenol boric...