A5102811849- Sperm and Testicular Function
- Hormonal and reproductive studies
- Reproductive Biology and Fertility
- Genetic and phenotypic traits in livestock
- Reproductive Physiology in Livestock
- Animal Genetics and Reproduction
- Animal Behavior and Welfare Studies
- CRISPR and Genetic Engineering
- Cancer, Hypoxia, and Metabolism
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Virus-based gene therapy research
- Genetic Mapping and Diversity in Plants and Animals
- Seed Germination and Physiology
- Cytokine Signaling Pathways and Interactions
- Glycosylation and Glycoproteins Research
- Nanoplatforms for cancer theranostics
- Herpesvirus Infections and Treatments
- Chronic Myeloid Leukemia Treatments
- Chromosomal and Genetic Variations
- Chronic Lymphocytic Leukemia Research
- Immune cells in cancer
- Plant tissue culture and regeneration
- Immunotherapy and Immune Responses
- Poxvirus research and outbreaks
- Xenotransplantation and immune response
Westmead Institute for Medical Research
2021-2024
The University of Sydney
2021-2024
The University of Texas MD Anderson Cancer Center
2014
New York Medical College
2012
North Carolina State University
1981-1994
University of Maryland, College Park
1994
Oklahoma State University
1972
Summary. Pig embryos at the 1- or 2-cell stage (before 'block' to development in vitro) were cultured 8 different media derived from Krebs'–Ringer–bicarbonate medium. A 2 × factorial arrangement was used for treatments, with glucose, glutamine and phosphate being major effects tested. Embryos obtained sows approximately 44–48 h after observation of oestrus, majority 1-cell stage. each female randomly assigned treatment. After in-vitro culture, all scored attained stained determine final cell...
Oligomeric, J-chain-containing immunoglobulins were observed to be transferred selectively from serum into colostrum. These studies suggest that, in the case of mammary gland secretion, a significant role for extraglandular synthesis IgA merits consideration. Thus, example, colostrum may contain antibodies synthesized locally as well much larger lymphoid tissues such gut lamina propria.
Paternal half-sib heritability and genetic correlation estimates were obtained utilizing data from 578 Hereford bulls 66 sires. Bulls maintained in three lines (weaning weight, postweaning gain control) of an ongoing selection project. Growth performance traits studied adjusted 205-d weaning 365-d individual feed efficiency, sonoray fat thickness gain. Heritability for these . 15 ± .17, .33 .19, .46 .21, .28 .18 .52 respectively. Scrotal measurements taken circumference both testes length...
Relationships of characteristics 24 h profiles for concentrations corticosteroids (CS), luteinizing hormone (LH) and testosterone (T) in peripheral blood with episodic exogenously induced elevations T were studied bulls. Hourly samples collected via jugular vein cannula consecutive from 11 puberal Angus Exogenous bovine LH (1 mg) was injected at the end period. The overall lag correlation between one hour subsequent (LAG-LHTCORR) significant (r = 0.34). Prolonged maintenance elevated CS...
HSV infects keratinocytes in the epidermis of skin via nectin-1. We established a human foreskin explant infection model to investigate entry and spread. HSV1 could only be achieved by topical application virus high density microarray projections (HD-MAPs) epidermis, which penetrated beyond one third its thickness, simulating vivo microtrauma. Rapid lateral spread mean 13 wide occurred after 24 hours free particles were observed between keratinocytes, consistent with an intercellular route...
The present investigation was conducted to evaluate the inhibitory effects of adrenal corticosteroids on testosterone production by bull testis. Administration a single i.v. dose adrenocorticotropic hormone (ACTH; 80 IU) resulted in corticosteroid peak which lasted approximately 6 h. During this h period, no episodic increases secretion LH or were initiated and basal concentrations suppressed (P<0.05) below control values. Episodic resumed 6–7 after ACTH when serum had returned levels. These...
The case described in this paper represents on the basis of cytogenetic evidence, first reported example a de novo tandem dup(5p)(p14→pter). Clinical changes were minimal, unlike previously cases which more complex structural chromosomal involved and phenotype was provisionally attributed to dup(5p) (p14 → pter). duplicated segment minimal effect identified than five eighths 5p. It is proposed that there localised critical elsewhere short arm chromosome 5 (p11–p13), when greater significance...
ABSTRACT Correlated responses in male reproductive traits were determined at 4, 6 and 8 weeks of age lines mice selected for large litter size (L+), 6-week body weight (W+), small (L+W-) (L-W+), an unselected control (K). Concentration serum testosterone weights testes, seminal vesicles, epididymides adrenal glands increased with age. Line differences concentration not detected. L+ W+ males exhibited positive correlated vesicle weights. Testis adjusted was significantly larger than controls...
The effects of porcine adrenocorticotropic hormone (ACTH) upon concentrations total corticosteroids, progesterone, testosterone, and luteinizing (LH) in peripheral serum LH-induced changes testosterone were studied 15 boars 5 barrows. Boars assigned to either ACTH-saline, ACTH-LH, or saline-LH treatments while all barrows received ACTH-LH. relationship between physiological corticosteroids during a 12 h control period was determined prior ACTH treatment. endogenous production this the...
Spermatozoa and testosterone production by testes of 6, 12, 24, 36 month old rabbits were quantified. Testosterone secretion decreased significantly with age when perfused an artificial medium containing exogenous gonadotropic hormones. Total daily sperm reached a peak at 24 months declined age. The fact that increases through indicates is adequate to maintain spermatogenesis. coincident reduced between suggestive cause effect relationship.
Data were collected from 1,245 Duroc boars and 527 Yorkshire boars. This represents 128 57 sires. Body weights, testis length combined testes width at 140 168 d obtained. Of these boars, 432 castrated a later age to evaluate relationships between in situ measures excised traits. Heritabilities for length, volume ranged .16 .25 both data. measurements .36 data sets. Favorable negative genetic found 104 kg backfat adjusted kg. Correlations among high positive. All testicular traits highly...
Journal Article Heterosis Estimates for Measures of Reproductive Traits in Crossbred Boars Get access J. D. Neely, Neely 3North Carolina State University, Raleigh 27650 Search other works by this author on: Oxford Academic PubMed Google Scholar B. H. Johnson, Johnson O. W. Robison Animal Science, Volume 51, Issue 5, November 1980, Pages 1070–1077, https://doi.org/10.2527/jas1980.5151070x Published: 01 1980
Although HIV infection inhibits interferon responses in its target cells vitro , signatures can be detected vivo soon after sexual transmission, mainly attributed to plasmacytoid dendritic (pDCs). In this study, we examined the physiological contributions of pDCs early acquisition using coculture models with myeloid DCs, macrophages and resting central, transitional effector memory CD4 T cell subsets. impacted a cell-specific manner. cells, was decreased via antiviral effects, maturation...
The ability of zeranol and trenbolone acetate (trenbolone) to alter testis function, weight gain carcass traits young bulls was studied. In Exp. 1, the effects age at initial implantation determined. After a 235-d experimental period, sequential (56-d intervals) beginning 100 or 150 d had reduced growth (P<.01), sperm production (P<.01) serum testosterone concentration in response gonadotropin releasing hormone (GnRH; P<.01). 200-d group partially suppressed, while 250-d not affected. Body...
Although interferon (IFN) has been often used as immunotherapy for bladder cancer, its efficacy is rather unsatisfactory, demanding further improvement.Combination therapy one of viable options, and grape seed proanthocyanidin (GSP) could be such an agent to with IFN because it shown have anticancer activity.We thus investigated whether combination GSP might enhance the overall antiproliferative effect on cancer cells in vitro.Human T24 were employed treated varying concentrations...
Data were collected from 1982 through 1992 100 sires and 891 Duroc boars. Testosterone production was measured peripheral blood samples before (PRE) after (POST) GnRH challenge. Additionally, data on testes volume at 168 d (TVOL), days to 104 kg (DAYS104), number born alive (NBA) backfat adjusted body weight (FAT). Realized heritabilities estimated the regression of response cumulative selection differentials. Heritabilities for POST .15 ± .18 .24 .08 in low high lines, respectively. This...
Changes in testicular and epididymal function selected endocrine organ size were examined a line of mice for rapid postweaning gain (M16) reciprocal crosses with an unselected pedigree control (ICR). The larger body weight the M16 was accompanied by testes, epididymides, seminal vesicle, pituitary, thyroid adrenal weights (P smaller than .01) although vesicle mice, expressed per gram weight, actually decreased relative to ICR line. Testicular sperm reserves higher but difference not...
Prenatal and postnatal influences on testicular development in boars were investigated utilizing crossfostering techniques. Dams paired within 24 hr after parturition randomly assigned to nurse either a large (14 pigs) or small (six litter. Each litter contained approximately equal numbers of progeny from each dam with males given preference during the transfer. Data collected 189 representing 42 litters three farrowing seasons. Pigs weaned at 56 days. Testes width, testes length body weight...
Abstract Glioblastoma multiforme (GBM) constitute the most aggressive and common form of primary brain tumors, conferring worst clinical prognosis. Epidermal growth factor receptor (EGFR) amplification, mutation re-arrangement are commonly observed genetic lesions in GBM. The frequently occurring EGFR variant GBM, EGFRvIII, is characterized by a truncated extracellular domain, leading to which unable bind ligand yet rendered constitutively active. In addition increasing proliferation...