A5038190858- Pesticide and Herbicide Environmental Studies
- Enzyme Catalysis and Immobilization
- Advanced Chemical Sensor Technologies
- Biochemical Analysis and Sensing Techniques
- RNA and protein synthesis mechanisms
- Bacteriophages and microbial interactions
- Environmental Toxicology and Ecotoxicology
- Pesticide Exposure and Toxicity
- Insect Resistance and Genetics
- Enzyme Structure and Function
- Pharmacogenetics and Drug Metabolism
- Metabolism and Genetic Disorders
- Biochemical and Molecular Research
- Microbial Metabolic Engineering and Bioproduction
- Health and Well-being Studies
- Protein Structure and Dynamics
- Analytical Methods in Pharmaceuticals
- Drug Transport and Resistance Mechanisms
- Education in Diverse Contexts
- RNA modifications and cancer
- Chemistry and Chemical Engineering
- Career Development and Diversity
- Chemical Reaction Mechanisms
- Educational Assessment and Pedagogy
- Chemical Safety and Risk Management
Ain Shams University
2022
Sigma Xi
2018
Triangle
2018
The University of Texas at Austin
2010-2017
Applied Natural Sciences
2013-2014
Texas A&M University
2005-2010
University of California, San Francisco
2006
Mobile group II introns encode reverse transcriptases (RTs) that function in intron mobility (“retrohoming”) by a process requires transcription of highly structured, 2–2.5-kb RNA with high processivity and fidelity. Although the latter properties are potentially useful for applications cDNA synthesis next-generation sequencing (RNA-seq), RTs have been difficult to purify free RNA, their utility as research tools has not investigated systematically. Here, we developed general methods...
Course-based undergraduate research experiences (CUREs) provide a promising avenue to attract larger and more diverse group of students into careers. CUREs are thought be distinctive in offering opportunities make discoveries, collaborate, engage iterative work, develop sense ownership their lab course work. Yet how these elements affect students’ intentions pursue research-related careers remain unexplored. To address this knowledge gap, we collected data on three design features...
With the emergence of sequences and even structures for proteins unknown function, structure-based prediction enzyme activity has become a pragmatic as well an interesting question. Here we investigate method to predict substrates enzymes known structure by docking high-energy intermediate forms potential substrates. A database such transition-state analogues was created from KEGG metabolites. To reduce number possible reactions consider, restricted ourselves amidohydrolase superfamily. We...
Organophosphorus compounds include many synthetic, neurotoxic substances that are commonly used as insecticides. The toxicity of these is due to their ability inhibit the enzyme acetylcholine esterase. Some most toxic organophosphates have been adapted for use chemical warfare agents; well-known GA, GB, GD, GF, VX, and VR. All contain a chiral phosphorus center, with SP enantiomers being significantly more than RP enantiomers. Phosphotriesterase (PTE) an capable detoxifying agents, but...
Glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes is a nonspecific diesterase that enables Escherichia coli to utilize alkyl phosphodiesters, such as diethyl phosphate, the sole phosphorus source. The catalytic properties of GpdQ were determined, and best substrate found was bis(p-nitrophenyl) phosphate with kcat/Km value 6.7 × 103 M-1 s-1. In addition, E. tested catalyst for hydrolysis series phosphonate monoesters which are products highly toxic organophosphonate nerve agents...
An array of 16 enantiomeric pairs chiral phosphate, phosphonate, and phosphinate esters was used to establish the breadth stereoselective discrimination inherent within bacterial phosphotriesterase 15 mutant enzymes. For each substrate, leaving group 4-hydroxyacetophenone while other two groups attached phosphorus core consisted an asymmetric mixture methyl, methoxy, ethyl, ethoxy, isopropoxy, phenyl, phenoxy, cyclohexyl, cyclohexoxy substituents. wild-type enzyme, relative rates hydrolysis...
Mobile group II introns, which are found in bacterial and organellar genomes, site-specific retroelments hypothesized to be evolutionary ancestors of spliceosomal introns retrotransposons higher organisms. Most bacteria, however, contain no more than one or a few making it unclear how could have proliferated copy numbers eukaryotic genomes. An exception is the thermophilic cyanobacterium Thermosynechococcus elongatus, contains 28 closely related copies intron, constituting ∼1.3% genome....
Differential sensing using synthetic receptors as mimics of the mammalian senses taste and smell is a powerful approach for analysis complex mixtures. Herein, we report on effectiveness cross-reactive, supramolecular, peptide-based array in differentiating predicting composition red wine blends. Fifteen blends Cabernet Sauvignon, Merlot Franc, addition to mono varietals, were used this investigation. Linear Discriminant Analysis (LDA) showed clear differentiation based tannin concentration...
Innovative models of teaching through research have broken the long-held paradigm that core chemistry competencies must be taught with predictable, scripted experiments. We describe here five fundamentally different, course-based undergraduate experiences integrate faculty projects, accomplish ACS accreditation objectives, provide benefits an early experience to students, and resulted in publishable findings. The model detailed is Freshman Research Initiative (FRI) at University Texas...
It is becoming increasingly important to differentiate complex mixtures, especially in forensics. Cachaça, the most popular alcoholic beverage Brazil, made from distilled and fermented sugar cane juice. contains a mixture of naturally occurring polyphenols known as tannins, whose composition dictated by type wood used age beverage. These tannins can be differentiated an Indicator Displacement Assay (IDA) using peptide-based ternary sensing ensembles. This investigation demonstrates technique...
This study examined the effects of Quran recitation on Heart Rate Variability (HRV) students. By doing so, this research extends previous findings religious activities university therefore studies relationship between HRV with different types reading styles (Tajweed), Surah (stories) and themes (i.e. heaven, hell punishment). The experiment comprises four sessions that each lasted approximately 30 minutes involved certain or verses. At end session, difference pre- post-session HRVs was...