A5014157514- Radical Photochemical Reactions
- Catalytic C–H Functionalization Methods
- Chemical synthesis and alkaloids
- Marine Sponges and Natural Products
- Asymmetric Hydrogenation and Catalysis
- Natural Compound Pharmacology Studies
- Synthesis of Indole Derivatives
- Crystallization and Solubility Studies
- Fluorine in Organic Chemistry
- X-ray Diffraction in Crystallography
- Sulfur-Based Synthesis Techniques
- Advanced Synthetic Organic Chemistry
The University of Melbourne
2023-2024
The University of Adelaide
2022
Abstract Organometallic reagents are routinely used as fundamental building blocks in organic chemistry to rapidly diversify molecular fragments via carbanion intermediates. However, the catalytic generation of equivalents, particularly from sp 3 -hybridized alkyl scaffolds, remains an underdeveloped goal chemical synthesis. Here we disclose approach for carbanions single-electron reduction aryl alkenes, enabled by multi-photon photoredox catalysis. We demonstrate that photocatalytically...
The field of biomimetic synthesis seeks to apply biosynthetic hypotheses the efficient construction complex natural products. This approach can also guide revision incorrectly assigned structures. Herein, we describe evolution a concise total and structural reassignment hyperelodione D, tetracyclic meroterpenoid derived from Hypericum plant, alongside some biogenetically related products, erectones A B. key step in D forms six stereocentres three rings bioinspired cascade reaction that...
The direct coupling of alkene feedstocks with aldehydes represents an expedient approach to the generation new and structurally diverse C(sp3)-hybridized alcohols that are primed for elaborated into privileged architectures. Despite their abundance, current disconnection strategies enabling carbon-carbon π-bonds remain challenging because contemporary methods often limited by substrate or functional group tolerance, compatibility in complex molecular environments. Here, we report a between...
The direct coupling of alkene feedstocks with aldehydes represents an expedient approach to the generation new and structurally diverse C(sp3)-hybridized alcohols that are primed for elaboration into privileged architectures. Despite their abundance, current disconnection strategies enabling carbon–carbon π-bonds remain challenging because contemporary methods often limited by substrate or functional group tolerance compatibility in complex molecular environments. Here, we report a between...
Abstract The field of biomimetic synthesis seeks to apply biosynthetic hypotheses the efficient construction complex natural products. This approach can also guide revision incorrectly assigned structures. Herein, we describe evolution a concise total and structural reassignment hyperelodione D, tetracyclic meroterpenoid derived from Hypericum plant, alongside some biogenetically related products, erectones A B. key step in D forms six stereocentres three rings bioinspired cascade reaction...
Organometallic reagents are routinely used as fundamental building blocks in organic chemistry to rapidly diversify molecular fragments via carbanion intermediates. However the catalytic generation of equivalents particularly from sp3-hybridized alkyl scaffolds, remains an underdeveloped goal chemical synthesis. To align with demands modern synthetic protocols, a general method for carbanions must operate under benign reaction conditions and access commercially available feedstock chemicals....