A5058596225- Streptococcal Infections and Treatments
- Infective Endocarditis Diagnosis and Management
- Neonatal and Maternal Infections
- Bacterial biofilms and quorum sensing
- Antimicrobial Resistance in Staphylococcus
- Bacterial Infections and Vaccines
- Antifungal resistance and susceptibility
- Antibiotic Resistance in Bacteria
- Bacterial Genetics and Biotechnology
- bioluminescence and chemiluminescence research
- Otolaryngology and Infectious Diseases
- Plant Pathogenic Bacteria Studies
- Bacterial Identification and Susceptibility Testing
Amsterdam Institute for Global Health and Development
2023-2024
Amsterdam University Medical Centers
2022-2024
University of Amsterdam
2022-2024
Imperial College London
2020-2024
Narodowy Instytut Leków
2024
University of California, Irvine
2024
UK Health Security Agency
2024
Instituto de Salud Carlos III
2024
GlaxoSmithKline (India)
2024
Boehringer Ingelheim (China)
2024
Streptococcus suis is an emerging zoonotic swine pathogen which can cause severe infections in humans. In March 2021, outbreak of S. with 19 confirmed cases septicemia and meningitis leading to two deaths, occurred Nakhon Ratchasima province, Thailand. We characterized the through epidemiological investigation combined Illumina Nanopore whole genome sequencing (WGS). The source was traced back a raw pork dish prepared from single pig during Buddhist ceremony attended by 241 people. WGS...
Streptococcus agalactiae, also known as group B (GBS), is the major cause of neonatal sepsis in humans.A critical step to infection adhesion bacteria epithelial surfaces.GBS adhesins have been identified bind extracellular matrix components and cellular receptors.However, several putative no host binding partner characterised.We report here that surfaceexpressed b protein GBS binds human CEACAM1 CEACAM5 receptors.A crystal structure complex showed an IgSF domain represents a novel Ig-fold...
Bacterial lifestyles depend on conditions encountered during colonization. The transition between planktonic and biofilm growth is dependent the intracellular second messenger c-di-GMP. High c-di-GMP levels driven by diguanylate cyclases (DGC) activity favor formation, while low maintained phosphodiesterases (PDE) encourage lifestyle. of these enzymes can be modulated stimuli-sensing domains such as PAS. In Pseudomonas aeruginosa, more than 40 PDE/DGC are involved in homeostasis, including...
Pseudomonas aeruginosa is a Gram-negative bacterium that able to survive and adapt in multitude of niches as well thrive within many different hosts. This versatility lies its large genome ca. 6 Mbp tight control the expression thousands genes. Among regulatory mechanisms widespread bacteria, cyclic-di-GMP signaling one which influences all levels control. c-di-GMP made by diguanylate cyclases degraded phosphodiesterases, while intracellular level this molecule drives phenotypic responses....
ABSTRACT Phase-variable type I restriction modification (RM) systems are epigenetic regulatory that have been identified in numerous human bacterial pathogens. We previously showed an emerging zoonotic lineage of Streptococcus suis acquired a phase-variable RM system, named SsuCC20p. The SsuCC20p locus was the genome multiple streptococcal species, indicating it is not restricted to S. and can be through horizontal gene transfer. demonstrate phase variability relies on recombinase present...
Abstract Phase-variable Type I Restriction Modification (RM) systems are epigenetic regulatory that have been identified in numerous human bacterial pathogens. We previously showed an emerging zoonotic lineage of Streptococcus suis acquired a phase-variable RM system named SsuCC20p. The SsuCC20p locus was present the genome disease-associated isolates from multiple streptococcal species. This indicates it is not restricted to S. and can be through horizontal gene transfer. demonstrate...
Abstract Streptococcus agalactiae , also known as group B (GBS), is the major cause of neonatal sepsis in humans. A critical step to infection adhesion bacteria at mucosal surfaces. Though several GBS adhesins have been identified, host receptor targets these remain unknown. We report here that surface-expressed β protein from binds human CEACAM1 and CEACAM5 receptors. crystal structure complex showed IgSF domain represents a novel Ig-fold subtype called IgI3, which unique features allow...