A5085760445- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Syphilis Diagnosis and Treatment
- Pregnancy and preeclampsia studies
Statens Serum Institut
1998-2023
Multiple mutations in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) increase transmission, disease severity, and immune evasion facilitate zoonotic or anthropozoonotic infections. Four such mutations, ΔH69/V70, L452R, E484K, N501Y, occurred the SARS-CoV-2 spike glycoprotein combinations that allow simultaneous detection VOCs. Here, we present two flexible reverse transcription-quantitative PCR (RT-qPCR) platforms for small- large-scale screening...
P = 0.017) and was highest for infants found supine.Unconditional analysis showed that quilt use attenuated the protective effect of sleeping supine compared with on side (common odds ratio test, 0.03).
Abstract Multiple mutations in SARS-CoV-2 variants of concern (VOCs) may increase, transmission, disease severity, immune evasion and facilitate zoonotic or anthoprozoonotic infections. Four such mutations, ΔH69/V70, L452R, E484K N501Y, occur the spike glycoprotein combinations that allow detection most important VOCs. Here we present two flexible RT-qPCR platforms for small-and large-scale screening to detect these schemes adapting future mutations. The platform, was validated by pair-wise...
Fast surveillance strategies are needed to control the spread of new emerging SARS-CoV-2 variants and gain time for evaluation their pathogenic potential. This was essential Omicron variant (B.1.1.529) that replaced Delta (B.1.617.2) is currently dominant circulating worldwide. RT-qPCR complement whole genome sequencing, especially in resource lean countries, but mutations targeting primer probe sequences can lead a failure existing RT-qPCRs. Here, we introduced an platform detecting Delta-...
Abstract Fast surveillance strategies are needed to control the spread of new emerging SARS-CoV-2 variants and gain time for evaluation their pathological potential. This was essential Omicron variant (B.1.1.529) that replaced Delta (B.1.617.2) is currently dominant circulating worldwide. RT-qPCR complement whole genome sequencing, especially in resource lean countries, but mutations targeting primer probe sequences can lead a failure existing RT-qPCRs. Here, we introduced an platform...