A simple efficient and neat synthesis of <TEX>${\alpha}$</TEX>-hydroxy phosphonates has been accomplished from aromatic/heterocyclic aldehydes diethyl phosphite using <TEX>$KHSO_4$</TEX> as a catalyst under solvent-free conditions at ambient temperature. These compounds are characterized by spectral analytical data tested for their anti-oxidant activity.

Syntheses of a new series biologically potent α‐aminophosphonates were accomplished by one‐pot Kabachnik–Fields reaction using TiO 2 –SiO as solid supported catalyst under microwave irradiation conditions. The chemical structures all the newly synthesized compounds confirmed analytical and spectral (IR, 1 H, 13 C, 31 P NMR, mass) data. Their anticancer nature was evaluated screening in vitro activity on two human cancer cell lines, HeLa SK‐BR‐3. Compounds 4i 4o showed best these cells even...

Abstract Biologically portent/significant tetrahydrodipyrazolo[3,4‐b:4′,3′‐ e ]pyridines are synthesized by an efficient green synthesis of various aldehydes with 3‐methyl‐1 H ‐pyrazol‐5(4 )‐one in ammonium acetate using phospho sulfonic acid as a solid catalyst under microwave‐assisted interaction solvent‐free conditions at 70°C. This methodology is easy to handle and get good excellent yields. Later the potential vitro antiproliferation titled compounds evaluated. Among all compounds, 4s...

A new class of di(α‐aminophosphonate) pesticides were prepared by the Kabachnik–Fields reaction under solvent‐ and catalyst‐free conditions with microwave irradiation, products obtained in good‐to‐excellent yields at shorter time. These compounds characterized IR, 1 H, 13 C, 31 P NMR, mass spectral data. Among them, 4f , 4c 4h showed good pesticidal activity against Spodoptera litura 92.6, 91.3, 89.3% mortality.

Abstract A series of novel chromone derivatives ( N -(4-oxo-2-(trifluoromethyl)-4 H -chromen-6-yl) benzamides) were synthesized by treating 7-amino-2-(trifluoromethyl)-4 -chromen-4-one with K 2 CO 3 and/or NaH, suitable alkyl halides and acetonitrile 1,4-dioxane. The obtained products are in high yields (87 to 96%) various substituents short reaction times no more by-products confirmed FT-IR, 1 H, 13 C-NMR Spectral data. vitro cytotoxic activity was examined against two human cancer cell...

Synthesis of α-aminophosphonates by a three-component condensation an aldehyde, amines and dialkyl phosphites in the presence non-ionic surfactant Triton X-100 catalyst at 70 °C aqueous medium is accomplished. The advantages are high yield, mild reaction conditions, simple work-up eco-friendliness. All newly-synthesized compounds (4a–j) exhibited moderate vitro antibacterial antifungal activities.

ABSTRACT The present work focuses on the study of catalytic activity polystyrene‐supported p ‐toluenesulfonic acid (PS/ P TSA) and synthesis α‐aminophosphonates from Kabachnik–Fields (KF) reaction under microwave irradiation in solvent‐free conditions. Recently, PS/ TSA was tested with good yields. This procedure is simplest, most straightforward, environment friendly method for simple to different substituted aldehyde substrates. Furthermore, this catalyst can be recovered reused without...

Abstract A series of a new class phosphorus analogue macrocycles was accomplished by condensation N‐substituted‐[bis(3,5‐dimethyl‐2‐hydroxybenzyl)]‐amines with various dichlorides in dry toluene the presence triethylamine at 0–50°C. All title compounds were evaluated for antimicrobial activity to determine their efficacy and effective suppressing growth bacteria fungi. The chemical structures products characterized IR, 1 H, 13 C, 31 P‐NMR, mass spectral studies, elemental analysis. J....

Abstract A new family of di(1‐oxo/thioxoper‐hydro‐1λ 5 ‐[1,3,2]diazaphospholo[1,5‐a]pyridine‐1‐yl)(4‐substituted phenyl) boronates ( 4a – j ) has been synthesized in a two‐step process. reaction (±)‐piperidin‐2‐yl‐methanamine 1 phosphoryl/phosphorothioyl chloride the presence triethylamine dry tetrahydrofuran formed intermediate monochloride 2 ), which on condensation with p‐substituted phenylboronic acids 3a afforded titled compounds ). They were characterized by elemental, IR, H, 13 C, 31...

Ytterbium perfluorooctanoate [Yb(PFO) 3 ] is found to be an efficient catalyst for the microwave‐irradiated synthesis of dihydropyrano[3,2‐ b ]chromenediones by one‐pot condensation kojic acid, aldehydes, and 1,3‐dicarbonyl compound under solvent‐free conditions. This approach offers many advantages, such as excellent product yields in short reaction time, conditions, easy isolation products, low loading, reusability catalyst, absence volatile hazardous emissions. The preliminary...

A simple and efficient one-pot microwave-assisted click formation of 1-(substituted)-1H-1,2,3-triazol-4-yl)methyl)diphenylphosphineoxide derivatives via Huisgen regioselective [3+2]-cycloaddition an in situ generated organic azides diphenyl(prop-2-yn-1-yl)phosphine oxide highly polar DMSO-H2O medium. This synthetic protocol is mild, requires shorter reaction time, afforded products excellent yields with high regioselectivity.

The present study is designed to synthesize the 2‐(5‐(substituted)‐2,6‐dioxo‐1,2,5,6‐tetrahydropyrimidin‐4‐yl)‐2,3‐dihydrophthalazine‐1,4‐diones and investigate their anticancer activity. This first example of condensation reaction a series phthalhydrazide derivatives in ionic liquid. In this investigation, titled compounds syntheses were carried out by simple efficient three component coupling phthalhydrazide, aldehydes, barbituric acid presence [Emim][BF 4 ] methodology was provided...

Synthesis of a new series (5-bromo-5-nitro-2-oxido-1,3,2- dioxaphosphinan-2-yl)amino acid esters (3a-l) was accomplished via two step process, which involves the prior preparation monochloride intermediate (2) and its subsequent reaction with amino in dry tetrahydrofuran presence triethylamine at reflux temperature. The title compounds structures were established by analytical, IR, 1H-, 13C- 31P-NMR, mass spectral data. They exhibited significant antibacterial antifungal activity.

Abstract A new class of biologically active 13‐membered phosphorus‐macroheterocycles ( 6a – l ) were conveniently synthesized from 1,2‐ bis (salicylidene amino)‐phenylene 1 ), by treating with phosporusoxychloride 3 and followed reacting various aromatic thiols amines 5f in one path, another path was directly treated phosphorodichloridates 2a e the presence triethylamine at 0–10°C under N 2 atmosphere THF. All title compounds confirmed analytical spectral data (IR, H‐, 13 C‐, 31 P‐NMR, mass...

Abstract A simple protocol is developed for the synthesis of title compounds via Michaelis—Arbuzov reaction diamido phosphites with various bromides.

Abstract Ten di(α‐aminophosphonates) are synthesized and evaluated towards their pesticidal activity with (IVb) showing the highest activity.

Abstract The title compounds (IV) (16 examples) are obtained by one‐pot, three‐component Kabachnik—Fields‐reaction under microwave irradiation conditions.

Abstract A green and highly efficient methodology for the formation of title compounds (IV) by one‐pot condensation kojic acid, various aromatic aldehydes, a cyclic 1,3‐dicarbonyl compound under microwave irradiation solvent‐free conditions is presented.