A5044300195- Plant Molecular Biology Research
- Plant Reproductive Biology
- RNA modifications and cancer
- Parasite Biology and Host Interactions
- Genomics and Phylogenetic Studies
- Photosynthetic Processes and Mechanisms
- Bacteriophages and microbial interactions
- Parasites and Host Interactions
- Vector-borne infectious diseases
- vaccines and immunoinformatics approaches
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Malaria Research and Control
- Toxoplasma gondii Research Studies
- Aquaculture disease management and microbiota
- Plant tissue culture and regeneration
University of Massachusetts Boston
2022-2025
Harvard University
2025
Peking University
2020-2023
State Key Laboratory of Protein and Plant Gene Research
2020-2021
State Key Laboratory of Plant Genomics
2020-2021
Measures to combat the parasites that cause malaria have become compromised because of reliance on a small arsenal drugs and emerging drug resistance. We conducted transposon mutagenesis screen in primate parasite Plasmodium knowlesi , producing most complete classification gene essentiality any spp. date, with resolution define truncatable genes. found conservation druggable genome between divergences mitochondrial metabolism. Perturbation analyses frontline antimalarial artemisinin...
Significance Germ cells (GCs) (i.e., the that are committed to meiosis and gametogenesis) key carriers for eukaryotes complete their life cycle, transmitting genetic information from one generation next while generating variations integrate environmental changes. Compared what has been known in animals, very little is about how GCs plants segregated somatic cells. This work demonstrates auxin a factor guiding GC specification Arabidopsis anthers. Local biosynthesis interacts with...
Babesiosis is an emerging zoonosis and widely distributed veterinary infection caused by 100+ species of Babesia parasites. The diversity parasites the lack specific drugs necessitate discovery broadly effective antibabesials. Here, we describe a comparative chemogenomics (CCG) pipeline for identification conserved targets. CCG relies on parallel in vitro evolution resistance independent populations spp. ( B. bovis divergens ). We identified potent antibabesial, MMV019266, from Malaria Box,...
Alkanes are widespread in the ocean, and Alcanivorax is one of most ubiquitous alkane-degrading bacteria marine ecosystem. Small RNAs (sRNAs) usually at heart regulatory pathways, but sRNA-mediated alkane metabolic adaptability still remains largely unknown due to difficulties identification. Here, differential RNA sequencing (dRNA-seq) modified with a size selection (~50-nt 500-nt) strategy was used generate high-resolution sRNAs profiling model species dieselolei B-5 under (n-hexadecane)...
Summary Germ cells (GCs) transmit genetic information from one generation to the next. Unlike animal GCs, plant GCs are induced post-embryonically, forming locally somatic cells. This induction is coordinated with organogenesis and might be guided by positional cues. In angiosperms, male initiate internal layers at four corners of anther primordia gradually enclosed parietal cell (PC) layers, leading a concentric GC-PC pattern. 1,2 However, underlying mechanism GC initiation pattern...
The tapetum is a special tissue within the stamen that supplies nutrients to support microspore differentiation. Many genes have been identified function in differentiation (Astrand et al., 2021). Ubiquitin C-terminal hydrolase (UCH) type of cysteine protease involved protein deubiquitination process (Mevissen and Komander, 2017) plays roles gonadal transformation spermatogenesis animals (Luo 2009; Kwon al,. 2004; Wang 2006). OsUCH3 (Os02g43760) was highly expressed early rice cells (Chen...
Abstract Babesiosis is an emerging zoonosis and widely distributed veterinary infection caused by 100+ species of Babesia parasites. The diversity parasites, coupled with the lack potent inhibitors necessitates discovery novel conserved druggable targets for generation broadly effective antibabesials. Here, we describe a comparative chemogenomics (CCG) pipeline identification targets. CCG relies on parallel in vitro evolution resistance independent populations evolutionarily-related spp. (...
Abstract Alkanes are widespread in the ocean, and Alcanivorax is one of most ubiquitous alkane-degrading bacteria marine ecosystem. Small RNAs (sRNAs) usually at heart regulatory pathways, but sRNA-mediated alkane metabolic adaptability still remains largely unknown due to difficulties identification. Here, differential RNA sequencing (dRNA-seq) modified with a size selection (∼50-nt 500-nt) strategy was used generate high-resolution sRNAs profiling model species dieselolei B-5 under ( n...