A5071460667- Catalytic Alkyne Reactions
- Nuclear reactor physics and engineering
- Catalytic C–H Functionalization Methods
- Catalytic Cross-Coupling Reactions
- Synthetic Organic Chemistry Methods
- Nuclear Materials and Properties
- Cyclopropane Reaction Mechanisms
- Heat transfer and supercritical fluids
- Graphite, nuclear technology, radiation studies
- Nuclear Engineering Thermal-Hydraulics
- Nuclear and radioactivity studies
- Malaria Research and Control
- Synthesis and Catalytic Reactions
- Cyclization and Aryne Chemistry
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Chemical synthesis and alkaloids
- Thin-Film Transistor Technologies
- Asymmetric Synthesis and Catalysis
- Oxidative Organic Chemistry Reactions
- Heat Transfer and Boiling Studies
- Fusion materials and technologies
- Organoboron and organosilicon chemistry
- Chemical Synthesis and Analysis
- Traditional and Medicinal Uses of Annonaceae
Hanyang University
2014-2024
CHA University
2024
LG (South Korea)
1991-2022
Seoul Institute
2018
Institute of Natural Science
2017
Idaho National Laboratory
2006-2016
Battelle
2014
Korea Aerospace University
2006
Ineos (United States)
2004
Instituto Nacional de Electricidad y Energías Limpias
2004
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRegiospecifically oxygen-18 labeled 1,2,4-trioxane: a simple chemical model system to probe the mechanism(s) for antimalarial activity of artemisinin (qinghaosu).Gary H. Posner and Chang Ho OhCite this: J. Am. Chem. Soc. 1992, 114, 21, 8328–8329Publication Date (Print):October 1, 1992Publication History Published online1 May 2002Published inissue 1 October...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanism-Based Design, Synthesis, and in vitro Antimalarial Testing of New 4-Methylated Trioxanes Structurally Related to Artemisinin: The Importance a Carbon-Centered Radical for ActivityGary H. Posner, Chang Ho Oh, Dasong Wang, Lucia Gerena, Wilbur K. Milhous, Steven R. Meshnick, Wanida AsawamahasadkaCite this: J. Med. Chem. 1994, 37, 9, 1256–1258Publication Date (Print):April 1, 1994Publication History Published online1 May 2002Published...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTZinc-modified cyanoborohydride as a selective reducing agentSunggak Kim, Chang Ho Oh, Jae Suk Ko, Kyo Han Ahn, and Yong Jin KimCite this: J. Org. Chem. 1985, 50, 11, 1927–1932Publication Date (Print):May 1, 1985Publication History Published online1 May 2002Published inissue 1 1985https://pubs.acs.org/doi/10.1021/jo00211a028https://doi.org/10.1021/jo00211a028research-articleACS PublicationsRequest reuse permissionsArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEvidence for Fe(IV):O in the Molecular Mechanism of Action Trioxane Antimalarial ArtemisininGary H. Posner, Jared N. Cumming, Poonsakdi Ploypradith, and Chang Ho OhCite this: J. Am. Chem. Soc. 1995, 117, 21, 5885–5886Publication Date (Print):May 1, 1995Publication History Published online1 May 2002Published inissue 1 1995https://doi.org/10.1021/ja00126a042RIGHTS & PERMISSIONSArticle Views616Altmetric-Citations137LEARN ABOUT THESE METRICSArticle...
No base is necessary: Excellent yields are produced on addition of organoboronic acids to alkynes under mild reaction conditions when palladium compounds used as catalysts (see scheme). Unlike the Suzuki-type cross-coupling reaction, current occurs in an acidic medium.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFurther Evidence Supporting the Importance of and Restrictions on a Carbon-Centered Radical for High Antimalarial Activity 1,2,4-Trioxanes Like ArtemisininGary H. Posner, Dasong Wang, Jared N. Cumming, Chang Ho Oh, Andrew French, Annette L. Bodley, Theresa A. ShapiroCite this: J. Med. Chem. 1995, 38, 13, 2273–2275Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June...
A new and novel Au-catalyzed cycloisomerization of ynals bearing a pendant unsaturated bond leading to synthetically valuable [6.7.n]-tricyclic compounds were developed. This study strongly supports the intermediacy [3 + 2] cycloaddition proposed by DFT calculation provides an easy access key skeletons found in variety natural products.
ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTHighly Efficient Arylation of Malonates with Diaryliodonium SaltsChang Ho Oh, Joo Sung Kim, and Hyung Hoon JungView Author Information Department Chemistry, Hanyang University, Haengdang-17 Sungdong-Gu, Seoul 133-791, Korea Cite this: J. Org. Chem. 1999, 64, 4, 1338–1340Publication Date (Web):February 1999Publication History Received3 June 1998Published online4 February 1999Published inissue 1...
Access granted: The platinum-catalyzed cyclization of enynals 1, which contain an additional alkene bond in their side chain, through a [3+2] cycloaddition to give tetracyclic platinum–carbene complexes A was followed by CH insertion at the δ position afford highly complex products 2. These polycyclic compounds and related title transformation are extremely difficult access other means.
o-(1,6-Enynyl)benzaldehydes underwent a novel mode of cycloaddition using Rh(I)-precatalyst, via [3 + 2] presumed dipolar carbonyl ylide intermediate generated by Rh-catalyst and the utility this mechanistically intriguing enyne cyclization can be found in number polycyclic natural product skeletons.
We have developed an efficient method for the synthesis of 2,3-disubstituted indoles from alkyne iminoethers 1 that employs a domino process involving Ag-catalyzed condensation followed by tandem Ag-induced cycloisomerization and 1,3-alkenyl shift to Ag-activated carbon. This methodology can be useful in regioselectively constructing 3-alkylated indoles, which are part structures biologically active compounds important alkaloids.
The escalating global demand for sustainable manufacturing, motivated by concerns over energy conservation and carbon footprints, encounters challenges due to insufficient renewable materials arduous fabrication procedures fulfill specific requirements in medical healthcare systems. Here, biosafe pollen cryogel is engineered as effective hemostats without additional harmful crosslinkers treat deep noncompressible wounds. A straightforward low-energy approach involved forming stable...
A palladium [2 + 2] cycloaddition of 1,6- and 1,7-allenyne carboxylates microwave-mediated various 1,n-allenynes were developed and, particularly, the microwave irradiated allenynes can provide a simple, general eco-friendly synthetic method to fused bicyclo[m,2,0]alkadienes.
BF3·OEt2 in methylene chloride at 25°C for 2 hours or less is shown to be effective easy conversion of tertiary alcohols into the corresponding thermodynamically most stable alkenes.
Good fusion: We describe the reactivity of Pt–carbene B, derived from enynals 1 via A, with Pt catalysts to afford fused cyclopropanes 2, which are obtained by insertion into CH bond β position. Acid-catalyzed rearrangement 2 smoothly occurred form spiranes 3 (see scheme). Detailed facts importance specialist readers published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted authors. Please note: The publisher is...
2-Alkynyl-1-cycloalkenecarbaldehydes, in the presence of gold catalysts, undergo aurative cyclization via 5-exo-dig mode to form Au-carbene intermediates which react with a double bond corresponding cyclopropanes.
Various 2-[6-en-1-ynyl]benzaldehydes and their analogues were successfully cyclized via Huisgen-type [3+2] cycloaddition to the tetracyclic platinum−carbene complex, which would subsequently undergo hydration afford tricyclic products in good yields with excellent stereoselectivities. This hydrative cyclization was also applied faveline synthesis.
A new Au-catalyzed cascade reaction was developed for the conversion of propargylic acetates 1 to benzannulated products 2 in good excellent yields. The gold catalyst is involved generating intermediate and ene-type B formation product (see scheme). As a service our authors readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed may be re-organized online delivery, but not copy-edited or typeset. Technical support issues arising from (other...
The Pd-catalyzed reaction of unsymmetrical alkynes with organoboronic acids gave a mixture products and, whose ratios were controlled by the electronic as well steric effects substrates.