A5109239787- Synthesis and Catalytic Reactions
- Synthetic Organic Chemistry Methods
- Oxidative Organic Chemistry Reactions
- Asymmetric Synthesis and Catalysis
- Microbial Natural Products and Biosynthesis
- Alkaloids: synthesis and pharmacology
- Synthesis of β-Lactam Compounds
- Advanced Synthetic Organic Chemistry
- Chemical Synthesis and Reactions
- Radical Photochemical Reactions
- Catalytic Cross-Coupling Reactions
- Cancer Treatment and Pharmacology
- Synthesis and Biological Activity
- 14-3-3 protein interactions
- Catalytic C–H Functionalization Methods
- Marine Sponges and Natural Products
- Phenothiazines and Benzothiazines Synthesis and Activities
- Sulfur-Based Synthesis Techniques
Sichuan University
2010-2025
Lanzhou University
2002-2003
Bryostatins are a family of marine natural products that have garnered significant interests, as evidenced by over 40 clinical trials. However, their extremely low abundance has severely limited further research. Despite efforts, which led to the total synthesis seven bryostatin members eight independent research groups, these complex molecules present persistent challenges for stereocontrolled, large‐scale, and especially divergent synthesis. Here, we report syntheses bryostatins 1, 7, 9...
Bryostatins are a family of marine natural products that have garnered significant interests, as evidenced by over 40 clinical trials. However, their extremely low abundance has severely limited further research. Despite efforts, which led to the total synthesis seven bryostatin members eight independent research groups, these complex molecules present persistent challenges for stereocontrolled, large‐scale, and especially divergent synthesis. Here, we report syntheses bryostatins 1, 7, 9...
A short and general approach to the cis-3a-aryloctahydroindole alkaloids has been developed on basis of a key stereocontrolled ZnBr2-catalyzed rearrangement 2,3-aziridino alcohols. Two representative members, (±)-crinane (±)-mesembrine, have synthesized in 15% 11% overall yields, respectively.
A new Lewis acid promoted rearrangement reaction of 2,3-aziridino alcohols was discovered, which involved the highly stereoselective construction a diastereogenic quaternary carbon center and efficient formation beta-amino carbonyl compounds in excellent yields. wide variety acids were proved to be effective for reaction, possible mechanism also discussed.
Allylic alcohols were found to undergo a semipinacol-type rearrangement induced by halogen cation generated from the chloramine-T/ZnX2 combination, which provided highly efficient and stereoselective method for preparation of α-quaternary β-haloketo compounds. This reaction is valuable versatile since quaternary carbon could be constructed effectively three kinds compounds (X = Cl, Br, I) achieved readily.
Abstract PhI(OAc) 2 /CuI‐promoted ring rearrangement of 1,3‐azasilinyl‐4‐epoxides has been developed. The reaction proceeds by a Si−C bond migration/oxidation process, leading to structurally novel 2‐silamorpolines containing an aryl/aldehyde groups‐substituted quaternary carbon.
Abstract The reaction provides six‐membered cyclic β‐silylenones (II) in moderate yields, whereas the five‐membered product (IV) is achieved excellent yield.
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