A5090202224- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Microscopic Colitis
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Tumor Research and Treatment
- Mycobacterium research and diagnosis
- Melanoma and MAPK Pathways
- Inflammatory Bowel Disease
- Esophageal and GI Pathology
- Clostridium difficile and Clostridium perfringens research
- Celiac Disease Research and Management
- Cytomegalovirus and herpesvirus research
- Colorectal Cancer Treatments and Studies
- Gallbladder and Bile Duct Disorders
- Viral gastroenteritis research and epidemiology
- Microbial Metabolites in Food Biotechnology
- Computational Drug Discovery Methods
- Eosinophilic Esophagitis
- Gastroesophageal reflux and treatments
- Dysphagia Assessment and Management
- Cancer Research and Treatments
- Gastrointestinal disorders and treatments
- Cytokine Signaling Pathways and Interactions
- Diverticular Disease and Complications
- Esophageal Cancer Research and Treatment
Columbia University Irving Medical Center
2017-2024
Saint Barnabas Medical Center
2024
Texas Health Dallas
2021
NewYork–Presbyterian Hospital
2018
Memorial Sloan Kettering Cancer Center
2017
Albert Einstein College of Medicine
2016
Montefiore Medical Center
2016
OBJECTIVES: Few studies have examined the role of non-Clostridium difficileenteric infections in flares inflammatory bowel disease (IBD). Our objective was to investigate enteric infection detected by multiplex PCR stool testing patients with IBD. METHODS: We performed a cross-sectional analysis 9403 who underwent 13,231 tests gastrointestinal pathogen panel during diarrheal illness from March 2015 May 2017. primary outcome presence an infection. Secondary outcomes included endoscopic and...
Abstract BRAF V600E colorectal cancers are insensitive to RAF inhibitor monotherapy due feedback reactivation of receptor tyrosine kinase signaling. Combined and EGFR inhibition exerts a therapeutic effect, but resistance invariably develops through undefined mechanisms. In this study, we determined that cancer progression specimens harbored lesions in elements the RAS–RAF–MEK–ERK pathway. Genetic amplification wild-type RAS was recurrent mechanism patients not seen similarly resistant...
With the development of all oral, interferon-free directly acting antiviral (DAA) medications, treatment hepatitis C virus (HCV) infection in renal transplant recipients is possible, but limited data exists on its safety and efficacy.We performed a retrospective cohort analysis patients transplanted at our center with HCV who have been started DAAs. Primary endpoints included sustained virologic response as defined negative viral load 12 weeks postcompletion therapy allograft function.A...
The similar presentations in relapse of inflammatory bowel disease (IBD) and enteric infection pose substantial barriers to diagnosis treatment. objective this study was investigate the incidence, etiology, predictors, treatment patients with IBD.We reviewed records 214 IBD who underwent 295 gastrointestinal pathogen panel Clostridium difficile (CDI) polymerase chain reaction (PCR) stool tests during an exacerbation symptoms. We collected baseline characteristics, PCR outcomes, medication...
The prevalence of depression in celiac disease (CD) is high, and patients are often burdened socially financially by a gluten-free diet. However, the relationship between depression, somatic symptoms dietary adherence CD complex poorly understood. We used patient powered research network (iCureCeliac®) to explore effect that has on patients' symptomatic response diet (GFD).We identified with biopsy-diagnosed who answered questions pertaining (Celiac Symptom Index (CSI)), GFD Dietary...
Goals: Through evaluation of the lower esophageal sphincter immediately before and after myotomy using an endoluminal functional lumen imaging probe (EFLIP), our study aimed to determine clinical response peroral endoscopic (POEM) incidence postprocedure reflux. Background: Achalasia is a rare motility disorder characterized by impaired relaxation (LES) diminished peristalsis. POEM therapeutic option for durable management achalasia. However, symptomatic acid reflux esophagitis are...
Diarrhea is common in persons living with HIV (PLWH)/AIDS. With the increasing utilization of multiplex gastrointestinal PCR panel (GI panel) testing, we aimed to characterize roles CD4 count and hospitalization GI assessments PLWH acute diarrhea.We performed a cross-sectional study adult diarrhea who underwent testing at two urban academic centers. Demographic, disease, result, data were collected, patients cohorted by (CD4 < 200, 200-499, > = 500). The primary outcome was enteric infection...
Patients with celiac disease (CD) commonly use supplements for perceived health benefits despite scant evidence. We aimed to characterize the prevalence and predictors of probiotic among CD patients.We analyzed data from iCureCeliac®; a patient-powered research network questionnaire distributed by Celiac Disease Foundation. included adults self-reported who answered questions regarding demographics, diagnosis, symptoms, treatment. compared users versus non-users subsequently performed...
Acid reflux is a well-known outcome after surgical or endoscopic myotomy, resulting from disruption of the natural anti-reflux barrier. The incidence post-myotomy GERD remains difficult to estimate as studies cite variable definitions including evidence reflux, abnormal pH testing, and symptoms. Future should focus on “clinically significant reflux” defined testing associated with either symptoms esophagitis. Large meta-analyses have demonstrated significantly higher rates acid exposure...
<div>Abstract<p><i>BRAF</i> V600E colorectal cancers are insensitive to RAF inhibitor monotherapy due feedback reactivation of receptor tyrosine kinase signaling. Combined and EGFR inhibition exerts a therapeutic effect, but resistance invariably develops through undefined mechanisms. In this study, we determined that cancer progression specimens harbored lesions in elements the RAS–RAF–MEK–ERK pathway. Genetic amplification wild-type RAS was recurrent mechanism...
<p>Supplementary Figures 1-5: Supplementary Figure 1 - validation and characterization of acquired genomic alterations, 2 RAS amplification leads to increased RAS-GTP dimerization RAF, 3 Increase in NRAS expression is sufficient cause resistance RAF/EGFR inhibition vitro CRC, 4 does not RAF melanoma, 5 Combined EGFR dimer inhibitors lead better signaling tumor growth than inhibitor alone BRAF V600E CRC.</p>
<p>Supplementary Figure Legends: Supplementary 1 - validation and characterization of acquired genomic alterations, 2 RAS amplification leads to increased RAS-GTP dimerization RAF, 3 Increase in NRAS expression is sufficient cause resistance RAF/EGFR inhibition vitro CRC, 4 does not RAF melanoma, 5 Combined EGFR dimer inhibitors lead better signaling tumor growth than inhibitor alone BRAF V600E CRC.</p>
<p>Supplementary Figures 1-5: Supplementary Figure 1 - validation and characterization of acquired genomic alterations, 2 RAS amplification leads to increased RAS-GTP dimerization RAF, 3 Increase in NRAS expression is sufficient cause resistance RAF/EGFR inhibition vitro CRC, 4 does not RAF melanoma, 5 Combined EGFR dimer inhibitors lead better signaling tumor growth than inhibitor alone BRAF V600E CRC.</p>