Patients with shift-work sleep disorder chronically have excessive sleepiness during night work and insomnia when attempting to the day. We evaluated use of modafinil for treating in patients this disorder.In a three-month, double-blind trial, we randomly assigned 209 receive either 200 mg or placebo before start each shift. Assessments were performed nighttime Multiple Sleep Latency Test, Clinical Global Impression Change, Psychomotor Vigilance diaries patients, daytime polysomnography....

ABSTRACTABSTRACTObjective: This study assessed the efficacy and safety of armodafinil, longer half-life enantiomer modafinil, for treatment excessive sleepiness in patients with narcolepsy.Research design methods: was a multicenter double-blind 196 (aged 18–65 years) randomized to receive armodafinil 150 mg (n = 65), 250 67), or placebo 64) once daily 12 weeks.Main outcome measures: Efficacy using Maintenance Wakefulness Test (MWT) (six 20‐min subtests across day), Clinical Global Impression...

Numerous mobile health (mHealth) interventions are being developed to aid in management of complex chronic medical conditions. However, the acceptance mHealth programs by low-income, bilingual populations has not yet been evaluated. The Trial Examine Text-based for Emergency department patients with Diabetes (TExT-MED) program is a text message-based designed specifically resource-poor diabetes. We conducted prospective proof-of-concept trial assess satisfaction and preliminary effectiveness...

Targeting gene-based therapeutics to the brain is a strategy actively sought treat Alzheimer's disease (AD). Recent findings discovered role of apolipoprotein E (ApoE) isoforms in clearance toxic amyloid beta proteins from brain. ApoE2 isoform beneficial for preventing AD development, whereas ApoE4 major contributing factor disease. In this paper, we demonstrated efficient brain-targeted delivery encoding plasmid DNA (pApoE2) using glucose transporter-1 (glut-1) targeted liposomes. Liposomes...

Alzheimer's disease (AD), the most common cause of dementia, inflicts enormous suffering to patients and their family members. It is third deadliest disease, affecting 46.8 million people worldwide. Brain-derived neurotrophic factor (BDNF) involved in development, maintenance, plasticity central nervous system. This crucial protein significantly reduced AD leading neuronal death. In this study, we demonstrate targeted delivery BDNF gene brain using liposome nanoparticles. These liposomes...

Partial response, no or residual symptoms following antidepressant therapy is common in clinical psychiatry. This study evaluated modafinil patients with major depressive disorder (MDD) who were partial responders to adequate selective serotonin reuptake inhibitor (SSRI) and excessive sleepiness fatigue.This retrospective analysis pooled the data of (18-65 yrs) participated two randomized, double-blind, placebo-controlled studies (6-week, flexible-dose 100-400 mg/day 8-week, fixed-dose 200...

Abstract Objectives Patients discharged from the emergency department ( ED ) are often referred for primary care, specialty, or other disease‐specific follow‐up appointments. Attendance at these scheduled appointments has been found to improve patient outcomes, decrease bounce‐backs, and reduce malpractice risk. Reasons missing visits complex, but most commonly reason cited by patients is simply forgetting. In this study authors evaluated ability of an automated text message reminder system...

The increasing prevalence of diabetes and the associated cost managing this complicated disease have a significant impact on public health outcomes expenditures, especially among resource-poor Latino patients. Mobile (mHealth) may be solution to reaching group improving their health.

Objective: To assess the pharmacodynamics of armodafinil compared with modafinil and placebo on measures alertness in healthy volunteers undergoing sleep loss.Research design methods: In a double-blind, active- placebo-controlled, parallel-group study, 107 male (aged 18–40 years) were randomized to receive single oral dose (100, 150, 200, or 300 mg), (200 administered at 19:25 h.Main outcome measures: The primary was Maintenance Wakefulness Test (MWT), every 2 hours from 22:00–08:00 h....

OBJECTIVE In the emergency department, hyperglycemic patients are screened for diabetic ketoacidosis (DKA) via a urine dipstick. this prospective study, we compared test characteristics of point-of-care β-hydroxybutyrate (β-OHB) analysis with RESEARCH DESIGN AND METHODS Emergency-department blood glucose ≥250 mg/dL had dipstick, chemistry panel, venous gas, and capillary β-OHB measurements. DKA was diagnosed according to American Diabetes Association criteria. RESULTS Of 516 subjects, 54...

Introduction: Patients with mental health conditions frequently use emergency medical services. Many suffer from substance and homelessness. If they the department (ED) as their primary source of care, potentially preventable frequent ED revisits hospital readmissions can worsen an already crowded healthcare system. However, magnitude to which homelessness affects service utilization among patients remains unclear in community. This study assessed impact on 30-day presenting urban,...

Social support interventions can improve diabetes self-care, particularly for Latinos, but are time and resource intensive. Mobile health may overcome these barriers by engaging training supporters remotely.

Multifunctional fatty acid grafted polymeric micelles are an effective and promising approach for drug gene delivery to the brain. An alternative bypass blood-brain barrier is administration through intranasal route. were prepared characterized pVGF In vitro expression was analyzed in bEnd.3 cells, primary astrocytes, neurons. Comparative in-vivo evaluate route of between intravenous. Biocompatible, multifunctional prepared, having average size 200 nm, cationic zeta potential. Modified...