A5102830662- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Breast Cancer Treatment Studies
- Ferroptosis and cancer prognosis
- Drug Transport and Resistance Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Metabolomics and Mass Spectrometry Studies
- Neurological Disorders and Treatments
- Nanoparticle-Based Drug Delivery
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- HER2/EGFR in Cancer Research
- Metastasis and carcinoma case studies
- Radiopharmaceutical Chemistry and Applications
- Neuroscience and Neuropharmacology Research
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Monoclonal and Polyclonal Antibodies Research
Ryazan State Medical University named after Academician I.P. Pavlov
2017-2023
Chelyabinsk Regional Clinical Oncology Center
2020
State Healthcare Institution "Regional Clinical Oncological Dispensary"
2019
Abstract Despite the advantages of neoadjuvant chemotherapy (NACT), associated toxicity is a serious complication that renders monitoring patients’ response to NACT highly important. Thus, prediction tumor treatment imperative avoid exposure potential non-responders deleterious complications. We have performed genome-wide analysis DNA methylation by XmaI-RRBS and selected CpG dinucleotides differential which discriminates luminal B breast cancer samples with different sensitivity NACT. With...
Despite advances in the diagnosis and treatment of breast cancer (BC), main cause deaths is resistance to existing therapies. An approach improve effectiveness therapy patients with aggressive BC subtypes neoadjuvant chemotherapy (NACT). Yet, response NACT for less than 65% according large clinical trials. obvious fact lack biomarkers predicting therapeutic effect NACT. In a search epigenetic markers, we performed genome-wide differential methylation screening by XmaI-RRBS cohorts responders...
To investigate the expression of PD-L1 in triple-negative and luminal B, HER2-negative breast carcinoma to assess association tumor status with prognosis disease.The PD-L1-status primary was studied 72 patients cancer, by using an immunohistochemical method.Differences were found incidence carcinomas cells depending on molecular genetic type: there a positive tumors 4 (14.81%) 27 cases 17 (37.78%) 45 cases. An analysis after neoadjuvant therapy revealed 1 18 moderate residual load 6 13 high...
Triple-negative breast cancer (TNBC) is the most aggressive molecular subtype, with a poor survival rate compared to others subtypes. For long time, chemotherapy was only systemic treatment for TNBC, and identification of actionable targets might ultimately improve prognosis TNBC patients. We performed genome-wide analysis DNA methylation at CpG islands on collection one hundred ten carcinoma samples six normal tissue using reduced representation bisulfite sequencing XmaI restriction enzyme...
The paper describes a clinical case of long-term Trastuzumab biotherapy patient with HER2-positive breast cancer. morphology confirmed HER2+ cancer has received therapy over 9 years. CT data proved complete resorption metastases in the lungs. No adverse events, which could limit trastuzumab treatment, were noted. illustrates effective metastatic
Aim. To study the spectrum of cellular molecular-biological markers and identify those them that can be used as prognostic factors for clinical course pulmonary adenocarcinoma.
 Material Methods. In given work archive material 129 patients with confirmed diagnosis adenocarcinoma was used. work, histological, immunohistochemical, molecular-genetic statistical methods were used.
 Results. 29 cases (47.5%) adenocarcinoma, focal cytoplasmic and/or nuclear expression p63 protein...
On wistar rats expression of P-glycoprotein in the brain after unilateral occlusion-reperfusion common carotid artery was studied. Correlation between transporter and redox status cerebral cortex assessed. Occlusion simulated under ether anesthesia by clamping using vascular clamp for 180 minutes followed recanalization. Samples were taken 60 min, 4 h, 24 5 days 14 reperfusion subjected to standard immunohistochemical processing, as well evaluating status. It revealed that 180-minute...