A5054921162- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Chemokine receptors and signaling
- Epilepsy research and treatment
- Machine Learning in Bioinformatics
- Tryptophan and brain disorders
- Pharmacological Effects and Toxicity Studies
- Drug Transport and Resistance Mechanisms
- Neonatal and fetal brain pathology
- Gut microbiota and health
- Neurogenesis and neuroplasticity mechanisms
- Epigenetics and DNA Methylation
Mario Negri Institute for Pharmacological Research
2021-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2022
Trinity College Dublin
2019
Abstract Objective Microgliosis occurs in animal models of acquired epilepsy and patients. It includes cell proliferation that is associated with seizure frequency decreased neuronal cells human epilepsy. The role microglia the development unknown; thus, we examined its contribution to spontaneous seizure, neurodegeneration, cognitive deficits different disease phases. Methods We used a model triggered by intra‐amygdala kainic acid C57BL6N adult male mice. Mice were...
Abstract Objective Physical exercise may improve neurological deficits and neuronal damage after acute brain injuries decrease established seizures. We investigated whether voluntary running wheel (RW) activity affects epileptogenesis in a mouse model of acquired epilepsy compared to sedentary mice. Methods Epilepsy was induced by intra‐amygdala kainate causing status epilepticus (SE) adult male Sham mice were implanted with electrodes injected saline, matched experimental In the RW‐1...
CXCL1, a functional murine orthologue of the human chemokine CXCL8 (IL-8), and its CXCR1 CXCR2 receptors were investigated in model acquired epilepsy developing following status epilepticus (SE) induced by intra-amygdala kainate. also studied temporal lobe (TLE). The involvement seizure generation neuronal cell loss was assessed mice using reparixin (formerly referred to as repertaxin), non-competitive allosteric inhibitor CXCR1/2 receptors. We found significant increase hippocampal CXCL1...
The gut microbiota is altered in epilepsy and emerging as a potential target for new therapies. We studied the effects of rifaximin, gastrointestinal tract-specific antibiotic, on seizures neuropathology alterations its mouse model temporal lobe (TLE). Epilepsy was induced by intra-amygdala kainate injection causing status epilepticus (SE) C57Bl6 adult male mice. Sham mice were injected with vehicle. Two cohorts SE fed rifaximin-supplemented diet 21 days, starting either at 24 h post-SE...