A5014709254- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical and Antibiotic Environmental Impacts
- Antibiotic Resistance in Bacteria
- Natural product bioactivities and synthesis
- Probiotics and Fermented Foods
- Milk Quality and Mastitis in Dairy Cows
- Biopolymer Synthesis and Applications
- Nanoparticle-Based Drug Delivery
- Toxin Mechanisms and Immunotoxins
- Magnesium Alloys: Properties and Applications
- Corrosion Behavior and Inhibition
- Radiopharmaceutical Chemistry and Applications
- Magnetic and Electromagnetic Effects
- Animal Nutrition and Physiology
- Phenothiazines and Benzothiazines Synthesis and Activities
- Phytochemical compounds biological activities
- Metal and Thin Film Mechanics
- Orthopaedic implants and arthroplasty
- Plant Toxicity and Pharmacological Properties
- Titanium Alloys Microstructure and Properties
- Drug-Induced Adverse Reactions
- Scheduling and Timetabling Solutions
- Effects of Radiation Exposure
- Polymer Surface Interaction Studies
- Blood groups and transfusion
University of Veterinary Medicine Hannover, Foundation
2017-2024
University of Bern
2023
National Foundation for Cancer Research
1975
Harvard University
1975
Cancer Research Foundation
1975
Universitätskinderklinik
1958
To determine the in vitro antimicrobial activity of N-acetylcysteine (NAC) against common pathogens associated with infectious keratitis dogs and cats, clinical isolates Staphylococcus (S.) pseudintermedius (n = 20), Streptococcus (St.) canis 10) Pseudomonas (P.) aeruginosa 7) canine feline ulcerative a quality control strain (P. DSM 19880) were tested. The minimal inhibitory concentration (MIC) NAC concentrations was determined using microdilution methodology. For S. P. aeruginosa, range...
Purpose To investigate the antimicrobial effect of cold atmospheric plasma (CAP) on pathogens associated with canine bacterial keratitis. Materials and methods Pseudomonas aeruginosa , Staphylococcus pseudintermedius Streptococcus canis strains, which were obtained from dogs infectious keratitis, subjected to testing. For each species, four isolates a reference strain cultivated Columbia sheep blood agar treated kiNPen Vet ® pen Neoplas GmbH, Greifswald, Germany. Various continuous treatment...
Equine malignant melanoma (EMM) is a frequently occurring dermoepidermal tumor in grey horses. Currently available therapies are either challenging or inefficient. Betulinic acid (BA), naturally triterpenoid, promising compound for cancer treatment. To evaluate the potential of BA as topical therapy EMM, its anticancer effects on primary equine cells and dermal fibroblasts percutaneous permeation through isolated skin were assessed vitro.BA showed antiproliferative cytotoxic both time-...
In biomedical engineering, laser powder bed fusion is an advanced manufacturing technology, which enables, for example, the production of patient-customized implants with complex geometries. Ti-6Al-7Nb shows promising improvements, especially regarding biocompatibility, compared other titanium alloys. The biocompatible features are investigated employing cytocompatibility and antibacterial examinations on Al2O3-blasted untreated surfaces. mechanical properties additively manufactured...
In orthopedic surgery, implant-associated infections are still a major problem. For the improvement of selective therapy in infection area, magnetic nanoparticles as drug carriers promising when used combination with magnetizable implants and an externally applied field. These principally increase strength field resulting enhanced accumulation loaded particles target area therewith reduction needed amount risk undesirable side effects. present study nanoporous silica core-shell...
In the European Union, various fluoroquinolones are authorised for treatment of food producing animals. Each administration poses an increased risk development and spread antimicrobial resistance. The aim this study was to investigate impact parenteral enrofloxacin on prevalence ciprofloxacin susceptibilities in commensal intestinal E. coli population. isolates from faeces twelve healthy pigs were included. Six administered day 1 3 after two weeks further three days. other formed control...
Gaining knowledge about the spread of resistance against antibacterial agents is a primary challenge in livestock farming. The purpose this study was to test effect double antibiotic treatment (at days 10⁻14 and 26⁻30) with enrofloxacin or solely environmental exposition (identical times, directly into litter) on commensal Escherichia coli comparison control (without treatment), depending different flooring. A total 720 Big 6 turkeys participated three trials. Four flooring designs were...
H1 receptor antagonists are commonly used for the treatment of allergic diseases. The aim this study was to find out, if antihistaminic compounds like mepyramine have ability influence activity antibacterials. Therefore, checkerboard method chosen detect these possible effects in vitro. Studies were performed with two different Escherichia coli (E. coli) strains as test microbes, treated antibacterials combination mepyramine. minimum inhibitory concentration (MIC) E. ATCC® 25922™ and PIG 01...
Mastitis in cattle is a major health problem as well incurring high costs for the dairy industry. To assess suitability of precision-cut bovine udder slices (PCBUS) mastitis studies, we infected PCBUS with 2 different Staphylococcus aureus strains. Accordingly, investigated both tissue response to infection based on immune mediators at mRNA and protein levels invasion bacteria within tissue. The studied proteins represent early inflammation [IL-1β, tumor necrosis factor-α (TNF-α),...
Extensive usage of fluoroquinolone antibiotics in livestock results their occurrence manure and subsequently the environment. Fluoroquinolone residues may promote bacterial resistance are toxic to plants aquatic organisms. Moreover, fluoroquinolones enter food chain through plant uptake, if is applied as fertilizer. Thus, presence environment pose a threat human ecological health. In this study, biotransformation enrofloxacin, marbofloxacin, difloxacin by fungus X. longipes (Xylaria) was...
Equine sarcoid (ES) is the most prevalent skin tumor in equids worldwide. Additionally, aging grey horses frequently suffer from equine malignant melanoma (EMM). Current local therapies targeting these tumors remain challenging. Therefore, more feasible topical treatment options should be considered. In order to develop a therapy against ES and EMM, betulinyl-bis-sulfamate NVX-207, derivatives of naturally occurring betulin betulinic acid, respectively, were evaluated for their...
Prudent use of antibiotics in livestock is widely considered to be important prevent antibiotic resistance. This study aimed evaluate the interactions between biofilms and veterinary therapeutic concentrations administrated via drinking water through a standardized experimental setup. In this context, two formed by pseudomonads (Pseudomonas (P.) aeruginosa or P. fluorescens) susceptible Escherichia (E.) coli strain were developed nutrient-poor medium on inner surface polyvinyl chloride pipe...
A major drawback of nanoparticles (NPs) for biomedical applications is their preferential phagocytosis in immune cells, which can be avoided by surface modifications like PEGylation. Nevertheless, examinations different polyethylene glycol (PEG) chain lengths on the competence cells as well possible immunotoxic effects are still sparse. Therefore, primary murine macrophages and dendritic were generated incubated with magnetic nanoporous silica (MNPSNPs) modified mPEG chains (2 kDa, 5 10...
Low-frequency electromagnetic fields (LF-EMF) may present an alternative to conventional sanitation methods of water supply lines in animal production. The objective this study was evaluate the effect application LF-EMF on bacterial concentrations and biofilms at scale-models different drinking systems (circulating non-circulating) conventionally used poultry holdings. Treated were equipped with commercial devices producing pulsed signals low frequency up 10,000 Hz; max. 21 mT. Exposure...
Abstract Background The aim of this study was to establish precision-cut bovine udder slices (PCBUS) as an in-vitro-model investigate pathophysiological processes in the early phase mastitis order have possibility new therapeutic approaches for treatment such inflammation later studies. Furthermore, model should contribute substitute in-vivo-experiments. Bovine is one most common and costly infectious diseases dairy industry, which largely associated with use antimicrobial agents. Given...
The naturally occurring betulinic acid (BA) and its derivative NVX-207 induce apoptosis in equine melanoma cells vitro. After topical application, high concentrations of the substances can be reached healthy skin. With aim to investigate effect safety topically applied BA horses with melanocytic tumors, longitudinal, prospective, randomized, double-blind, placebo-controlled study protocol included eighteen Lipizzaner mares early-stage cutaneous assigned three groups. Melanocytic lesions were...
The development of bioresorbable materials for temporary implantation enables progress in medical technology. Iron (Fe)-based degradable are biocompatible and exhibit good mechanical properties, but their degradation rate is low. Aside from alloying with Manganese (Mn), the creation phases high electrochemical potential such as silver (Ag) to cause anodic dissolution FeMn promising. However, enable residue-free dissolution, Ag needs be modified. This concern addressed, modified a...