A5028157771- Bacterial biofilms and quorum sensing
- Glycosylation and Glycoproteins Research
- Respiratory viral infections research
- Systemic Lupus Erythematosus Research
- Lung Cancer Research Studies
- Probiotics and Fermented Foods
- Rheumatoid Arthritis Research and Therapies
- Gut microbiota and health
- Antibiotic Resistance in Bacteria
- Galectins and Cancer Biology
- Bacterial Identification and Susceptibility Testing
- Vibrio bacteria research studies
- Spondyloarthritis Studies and Treatments
- Bacterial Genetics and Biotechnology
- Electrochemical Analysis and Applications
- Helicobacter pylori-related gastroenterology studies
- Pneumonia and Respiratory Infections
- Bioactive Compounds and Antitumor Agents
- Phagocytosis and Immune Regulation
- Essential Oils and Antimicrobial Activity
- Cystic Fibrosis Research Advances
- Antimicrobial Resistance in Staphylococcus
- Bacteriophages and microbial interactions
- Cancer therapeutics and mechanisms
- Inhalation and Respiratory Drug Delivery
Utrecht University
2020-2024
University College Dublin
2024
Amrita Vishwa Vidyapeetham
2016-2022
Amrita Institute of Medical Sciences and Research Centre
2012-2018
Institute of Post Graduate Medical Education and Research
2011-2013
Mucins play an essential role in protecting the respiratory tract against microbial infections while also acting as binding sites for bacterial and viral adhesins. The heavily O-glycosylated gel-forming mucins MUC5AC MUC5B eliminate pathogens by mucociliary clearance. Transmembrane MUC1, MUC4, MUC16 can restrict invasion at apical surface of epithelium. In this study, we determined impact host mucin glycans on epithelial entry SARS-CoV-2. Human lung Calu-3 cells express SARS-CoV-2 receptor...
ABSTRACT Reports of oxacillin-susceptible mecA -positive Staphylococcus aureus strains are on the rise. Because their susceptibility to oxacillin and cefoxitin, it is very difficult detect them by using routine phenotypic methods. We describe two such isolates that were detected chromogenic medium confirmed characterization gene element.
The intestinal mucosal barrier is a dynamic system that allows nutrient uptake, stimulates healthy microbe–host interactions, and prevents invasion by pathogens. mucosa consists of epithelial cells connected cellular junctions regulate the passage nutrients covered mucus layer plays an important role in host–microbiome interactions. Mimicking for vitro assays, particularly generation layer, has proven to be challenging. cell-line Caco-2 widely used academic industrial laboratories due its...
The effect of anacardic acid impregnation on catheter surfaces for the prevention Staphylococcus aureus attachments and biofilm formations were evaluated. Silicon tubes impregnated using different concentrations acids (0·002–0·25%). Anacardic are antibacterial phenolic lipids from cashew nut (Anacardium occidentale) shell oil. acid‐impregnated silicon catheters revealed no significant haemolytic activity cytocompatible against fibroblast cell line (L929). Sustained release was observed 4...
Biofilm development in Pseudomonas aeruginosa is regulated by its quorum sensing (QS) systems. It has three major QS systems: LasI/R, RhlI/R and PQS/MvfR. Previous studies showed that phenyllactic acid (PLA) binds to RhlR PqsR inhibits the Rhl PQS QS; eugenol at sublethal concentration Las Here, we have demonstrated a combination of doses PLA enhanced inhibition mediated production virulence factors biofilm this pathogen. A 50 μmol l-1 0·3 mmol significantly inhibited pyocyanin production,...
Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation resulting from an inappropriate inflammatory response to microbes in a genetically susceptible host. Reactive oxygen species (ROS) generated NADPH oxidases (NOX) provide antimicrobial defense, redox signaling and gut barrier maintenance. oxidase mutations have been identified IBD patients, mucus layer disruption, critical aspect pathogenesis, was connected NOX inactivation. To gain insight into ROS-dependent...
Mucus plays an essential role in protecting the respiratory tract against microbial infections. The major components of mucus are heavily O-glycosylated mucin glycoproteins, constitutively expressed at surface epithelia where pathogens enter cells. gel-forming mucins MUC5AC and MUC5B facilitate efficient elimination by mucociliary clearance. transmembrane (TM) MUC1, MUC4, MUC16 to restrict invasion apical surface. SARS-CoV-2 targets resulting illness spectrum ranging from mild severe that...
Abstract Mucins play an essential role in protecting the respiratory tract against microbial infections but can also serve as binding sites for bacterial and viral adhesins. The heavily O -glycosylated gel-forming mucins MUC5AC MUC5B eliminate pathogens by mucociliary clearance while transmembrane MUC1, MUC4, MUC16 restrict invasion at apical surface of epithelium. In this study, we determined impact host mucin glycans on SARS-CoV-2 epithelial entry. Human lung Calu-3 cells express entry...