Guoquan Zhang

ORCID: 0000-0002-7273-8755
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Research Areas
  • Environmental and Agricultural Sciences
  • Vector-borne infectious diseases
  • Viral Infections and Vectors
  • Forest, Soil, and Plant Ecology in China
  • Mosquito-borne diseases and control
  • Plant Ecology and Soil Science
  • Ecology and Conservation Studies
  • Flowering Plant Growth and Cultivation
  • Sport and Mega-Event Impacts
  • Crop Yield and Soil Fertility
  • Mycobacterium research and diagnosis
  • Redox biology and oxidative stress
  • Gout, Hyperuricemia, Uric Acid
  • Toxoplasma gondii Research Studies
  • Consumer Market Behavior and Pricing
  • Peripheral Neuropathies and Disorders
  • Allelopathy and phytotoxic interactions
  • Aviation Industry Analysis and Trends
  • Bacterial Infections and Vaccines
  • Inflammasome and immune disorders
  • Transport and Economic Policies
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Evaluation and Optimization Models
  • Educational Systems and Policies
  • Proteins in Food Systems

North China University of Science and Technology
2025

The University of Texas at San Antonio
2022-2024

University of Missouri
2013-2022

Northwest A&F University
2020

University of Southern Queensland
2020

Bohai University
2015-2017

Missouri College
2013-2016

Science and Technology Department of Sichuan Province
2011

Zhejiang A & F University
2010

Charles Sturt University
2007

ABSTRACT Host control of Coxiella burnetii infections is believed to be mediated primarily by activated monocytes/macrophages. The activation macrophages cytokines leads the production reactive oxygen intermediates (ROI) and nitrogen (RNI) that have potent antimicrobial activities. contributions ROI RNI inhibition C. replication were examined in vitro use murine macrophage-like cell lines primary mouse macrophages. A gamma interferon (IFN-γ) treatment infected resulted an increased nitric...

10.1128/iai.72.11.6666-6675.2004 article EN Infection and Immunity 2004-10-22

Coxiella burnetii is an obligate intracellular bacterium that causes acute and chronic Q fever in humans. Human mainly transmitted by aerosol infection. However, there a fundamental gap the knowledge regarding mechanisms of pulmonary immunity against C. This study focused on understanding interaction between innate immune cells vitro vivo. Both virulent Nine Mile phase I (NMI) avirulent II (NMII) were able to infect neutrophils, while infection rates lower than 29%, suggesting can but...

10.1128/iai.00973-13 article EN Infection and Immunity 2013-10-01

ABSTRACT Despite Coxiella burnetii being an obligate intracellular bacterial pathogen, our recent study demonstrated that B cells play a critical role in vaccine-induced immunity to C. infection by producing protective antibodies. However, the of host defense against primary remains unclear. In this study, we investigated whether important infection. The results showed peritoneal were able phagocytose virulent bacteria and form -containing vacuoles (CCVs) can infect replicate B1a subset...

10.1128/iai.01073-15 article EN Infection and Immunity 2015-10-06

Our recent study demonstrated that virulent Coxiella burnetii Nine Mile phase I (NMI) is capable of infecting and replicating within peritoneal B1a cells play an important role in host defense against C. infection mice. However, it remains unknown if avirulent II (NMII) can infect replicate whether NMI NMII differentially interact with cells. In this study, we examined modulate cell apoptotic signaling The results showed induced dose-dependent death murine but did not, suggesting may...

10.1128/iai.00694-16 article EN Infection and Immunity 2016-10-11

Coxiella burnetii is an obligate intracellular Gram-negative bacterium that causes Q fever, a life-threatening zoonotic disease. C. replicates within acidified parasitophorous vacuole derived from the host lysosome. The ability of to replicate and achieve successful life in cell cytosol vastly dependent on Dot/Icm type 4B secretion system (T4SSB). Although several T4SSB effector proteins have been shown be important for virulence replication, role icmE protein host–C. interaction has not...

10.3390/pathogens13050405 article EN cc-by Pathogens 2024-05-14

Coxiella burnetii is an obligate intracellular Gram-negative bacterium that causes Q fever in humans. The virulent C. Nine Mile phase I (NMI) strain disease animal models, while the avirulent NM II (NMII) does not. In this study, we found NMI infection induces severe splenomegaly and bacterial burden spleen BALB/c mice, NMII A significantly higher number of CD11b+ Ly6G+ neutrophils accumulated liver, lung, NMI-infected mice than NMII-infected mice. Thus, neutrophil accumulation correlates...

10.1128/iai.00534-21 article EN Infection and Immunity 2022-01-31

Using the theory and method of bibliometrics, this paper made statistical analysis on research papers 16 main woody medical plants published in period 1998-2007, from aspects years distribution, journals themes authors distribution institutes so on. The results showed studies, status quto development potential plants.

10.4268/cjcmm20100525 article EN China Journal of Chinese Materia Medica 2010-03-01

With the development of China's economy and trend economic globalization, sports culture has increasingly become a representative country excellent culture.Sports cultural creativity industry as one important part is also showing good in development.Firstly, significance meaning introduced; then, in-depth analyzing problems existing industry; finally, specific measures countermeasures are put forward for development.Although just starting, background, resources thinking promote another...

10.2991/essaeme-15.2015.128 article EN cc-by-nc 2015-01-01

China's urban and rural dual structure makes education development unbalanced, obvious difference between areas, school sports lags behind, primary middle schools physical gets out of the trouble as soon possible is problem to be solved.This paper takes basic theory guidance, in view current situation education, which puts forward some countermeasures strengthening education: straightening relationship quality promotes students all-round healthy growth; strengthen concept health teaching,...

10.2991/essaeme-17.2017.441 article EN cc-by-nc 2017-01-01
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