A5001937942- Intraperitoneal and Appendiceal Malignancies
- DNA Repair Mechanisms
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Colorectal Cancer Treatments and Studies
- Immune Cell Function and Interaction
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- vaccines and immunoinformatics approaches
- Hepatocellular Carcinoma Treatment and Prognosis
- Gene expression and cancer classification
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- T-cell and B-cell Immunology
- Computational Drug Discovery Methods
- High Altitude and Hypoxia
- PARP inhibition in cancer therapy
- Mitochondrial Function and Pathology
- Endometriosis Research and Treatment
- Single-cell and spatial transcriptomics
- Medical Imaging and Pathology Studies
Oslo University Hospital
2011-2024
University of Oslo
2020-2024
Institute of Clinical Research
2021
Norwegian Cancer Society
2017
Recent large-scale undertakings such as ENCODE and Roadmap Epigenomics have generated experimental data mapped to the human reference genome (as genomic tracks) representing a variety of functional elements across large number cell types. Despite high potential value these publicly available for broad investigations, little attention has been given analytical methodology necessary their widespread utilisation.
Background Pseudomyxoma peritonei (PMP) is a rare, slow-growing abdominal cancer with no efficacious treatment options in non-resectable and recurrent cases. Otherwise, rare activating mutations the GNAS oncogene are remarkably frequent PMP mutated gene product, guanine nucleotide-binding protein α subunit (Gsα), potential tumor neoantigen, presenting an opportunity for targeting by therapeutic vaccine. Methods Tumor blood samples were collected from 25 patients undergoing surgery (...
Abstract Background Patients with peritoneal metastasis from colorectal cancer (PM-CRC) have inferior prognosis and respond particularly poorly to chemotherapy. This study aims identify the molecular explanation for observed clinical behavior suggest novel treatment strategies in PM-CRC. Methods Tumor samples (230) a Norwegian national cohort undergoing surgery hyperthermic intraperitoneal chemotherapy (HIPEC) mitomycin C (MMC) PM-CRC were subjected targeted DNA sequencing, associations data...
To study outcomes after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) in patients also treated for colorectal liver metastases (CLM).
Abstract Adaptive immune receptor repertoires (AIRR) are key targets for biomedical research as they record past and ongoing adaptive responses. The capacity of machine learning (ML) to identify complex discriminative sequence patterns renders it an ideal approach AIRR-based diagnostic therapeutic discovery. To date, widespread adoption AIRR ML has been inhibited by a lack reproducibility, transparency, interoperability. immuneML ( immuneml.uio.no ) addresses these concerns implementing each...
Although microRNAs (miRNAs) contribute to all hallmarks of cancer, miRNA dysregulation in metastasis remains poorly understood. The aim this work was reliably identify miRNAs associated with metastatic progression colorectal cancer (CRC) using novel and previously published next-generation sequencing (NGS) datasets generated from 268 samples primary (pCRC) CRC (mCRC; liver, lung peritoneal metastases) tumor adjacent tissues. Differential expression analysis performed a meticulous...
Mucinous peritoneal metastases (PM) generally respond poorly to systemic treatment, and there is a clear unmet need for new treatment strategies improve survival quality of life patients with PM. In this work, the growth inhibitory effect five drugs (oxaliplatin (OXA; 5 mg/kg), irinotecan (IRI; 60 cabazitaxel (CBZ; 15 or 30 regorafenib (REG; 10, capecitabine (CAP; 359 755 mg/kg) was investigated in three orthotopic patient-derived xenograft models that mimic mucinous Drugs were administered...
Abstract Background Colorectal liver metastasis (CLM) is a leading cause of colorectal cancer mortality, and the response to immune checkpoint inhibition (ICI) in microsatellite-stable CRC has been disappointing. Administration cytotoxic chemotherapy may increased density tumor-infiltrating T cells, which associated with improved ICI. This study aimed quantify characterize T-cell infiltration CLM using receptor (TCR) repertoire sequencing. Eighty-five resected CLMs from patients included...
Peritoneal malignant mesothelioma is a rare disease with generally poor prognosis and response to chemotherapy. To improve survival there need for increased molecular understanding of the disease, including chemotherapy sensitivity resistance. We here present an unusual case concerning young woman extensive peritoneal who had remarkable palliative (platinum/pemetrexed). Tumor samples collected at surgery before after treatment were analyzed on genomic transcriptional levels (exome...
A visualization referred to as rainfall plot has recently gained popularity in genome data analysis. The is mostly used for illustrating the distribution of somatic cancer mutations along a reference genome, typically aiming identify mutation hotspots. In general terms, can be seen scatter showing location events on x-axis versus distance between consecutive y-axis. Despite its frequent use, motivation applying this particular and appropriateness usage have never been critically addressed...
Abstract Genome-wide, cell-type-specific profiles are being systematically generated for numerous genomic and epigenomic features. There is, however, no universally applicable analytical methodology such data. We present GSuite HyperBrowser, the first comprehensive solution integrative analysis of dataset collections across genome epigenome. The HyperBrowser is an open-source system streamlined acquisition customizable statistical large genome-wide datasets. based on new computational...
Metastatic colorectal cancer (mCRC) is the main cause of CRC mortality, with limited treatment options. Although immunotherapy has benefited some patients, mCRC typically lacks molecular features that respond to this treatment. However, recent studies indicate immune microenvironment may be modified enhance effect checkpoint inhibitors. This study aimed explore metastatic tumor (TME) by comparing cell populations in liver (CLM), lung (mLu), and peritoneal (PM) metastases.
Abstract Objective: Patients with peritoneal metastasis (PM) from colorectal cancer (CRC) have inferior prognosis and respond poorly to chemotherapy compared other metastatic locations. This study aims identify the molecular explanation for observed clinical behavior suggest novel treatment strategies in PM-CRC. Design: Tumor samples a Norwegian national cohort of 230 patients undergoing surgery hyperthermic intraperitoneal (HIPEC) mitomycin C (MMC) PM-CRC were subjected targeted DNA...
Abstract Colorectal Cancer (CRC) is one of the leading causes cancer related deaths in western world, and metastatic progression dominating cause mortality. The primary site CRC metastasis liver, followed by lungs peritoneal cavity, prognosis for patients with (mCRC) poor, only 10 % five-year survival. Although much known about CRC; how (pCRC) differs from mCRC on molecular level potential differences between metastases located different organs are incompletely understood. This important our...
Abstract Although microRNAs (miRNA) are involved in all hallmarks of cancer, miRNA dysregulation metastasis remains poorly understood and contradictory results have been published. The aim this work was to identify miRNAs associated with metastatic progression colorectal cancer (CRC). Novel previously published next generation sequencing (NGS) datasets generated from 268 samples primary (pCRC) CRC (mCRC; liver, lung peritoneal metastases) tumor adjacent tissues were analyzed. Differential...
Background: Colorectal liver metastasis (CLM) is a leading cause of colorectal cancer mortality, and the response to immune checkpoint inhibition (ICI) in microsatellite stable CRC has been disappointing. Administration cytotoxic chemotherapy may increased density tumour infiltrating T cells, which associated with improved ICI. The aim this study was quantify characterize cell infiltration CLM using receptor (TCR) repertoire sequencing.Methods: Eighty-five resected from patients included...