A5063648079- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- RNA Interference and Gene Delivery
- Animal Virus Infections Studies
- Nanocomposite Films for Food Packaging
- interferon and immune responses
- vaccines and immunoinformatics approaches
- Galectins and Cancer Biology
- Inflammasome and immune disorders
- SARS-CoV-2 and COVID-19 Research
- Cancer-related molecular mechanisms research
- Advanced Drug Delivery Systems
- Connexins and lens biology
Trinity College Dublin
2018-2024
New York Institute of Technology
2001
Chitosan is a cationic polysaccharide that has been evaluated as an adjuvant due to its biocompatible and biodegradable nature. The can enhance antibody responses cell-mediated immunity following vaccination by injection or mucosal routes. However, the optimal polymer characteristics for activation of dendritic cells (DCs) induction antigen-specific cellular immune have not resolved. Here, we demonstrate only chitin-derived polymers with high degree deacetylation (DDA) generation...
Stimulator of IFN genes (STING) is a promising target for adjuvants utilized in situ cancer vaccination approaches. However, key barriers remain clinical translation, including low cellular uptake and accessibility, STING variability necessitating personalized agonists, interferon (IFN)-independent signals that can promote tumor growth. Here, we identify C100, highly deacetylated chitin-derived polymer (HDCP), as an attractive alternative to conventional agonists. C100 promotes potent...
Abstract The purpose of this research project was to characterize the distribution left-handed Z-RNA sequences within epithelial cells adult noncataractous crystalline dog lens: meridional rows (MR). This achieved by using anti-Z-RNA IgG polyclonal antibody probes. Both light microscopy (LM) and electron (EM) were used analyze tissue binding anti- antibodies. Nucleic acids can adopt many different helical conformations (1), such as Z-DNA (Fig. 1) (2,3). lens is made up a single cell type,...