A5101936067- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Medicinal Plants and Neuroprotection
- Trace Elements in Health
- Cholinesterase and Neurodegenerative Diseases
- Inflammasome and immune disorders
- Tryptophan and brain disorders
- Parkinson's Disease Mechanisms and Treatments
- Heavy Metal Exposure and Toxicity
- Medicinal Plants and Bioactive Compounds
- Computational Drug Discovery Methods
- Corneal Surgery and Treatments
- RNA regulation and disease
- Cholesterol and Lipid Metabolism
- Genomics, phytochemicals, and oxidative stress
- Intraocular Surgery and Lenses
- Cancer Mechanisms and Therapy
- Angiogenesis and VEGF in Cancer
- Bioinformatics and Genomic Networks
- Urinary and Genital Oncology Studies
- Alcoholism and Thiamine Deficiency
- Case Reports on Hematomas
- Nerve injury and regeneration
- Nuclear Receptors and Signaling
- Colorectal Cancer Screening and Detection
Shandong Agricultural University
2025
Hunan Provincial People's Hospital
2019-2025
Shanghai Jiao Tong University
2025
China Medical University
2014-2024
Shenzhen Genoimmune Medical Institute
2024
Shenyang Center for Disease Control and Prevention
2018-2022
Beijing University of Chemical Technology
2017
Sichuan University
2017
West China Hospital of Sichuan University
2017
First Affiliated Hospital of Gannan Medical University
2010
Summary Aims Baicalin (BAI), a flavonoid compound isolated from the root of Scutellaria baicalensis Georgi, has been established to have potent anti‐inflammation and neuroprotective properties; however, its effects during Alzheimer's disease ( AD ) treatment not well studied. This study aimed investigate BAI pretreatment on cognitive impairment neuronal protection against microglia‐induced neuroinflammation explore mechanisms underlying effects. Methods To determine whether plays positive...
Scope In this study, it has been investigated whether the neuroprotective efficacy of epigallocatechin‐3‐gallate (EGCG) is mediated by inhibition canonical and noncanonical inflammasome activation via toll‐like receptor 4 (TLR4)/NF‐κB pathway both in LPS+Aβ‐induced microglia vitro APP/PS1 mice vivo. Methods results BV2 cells, EGCG inhibits expressions Iba‐1, cleaved IL‐1β, IL‐18 induced LPS+Aβ. Then, supernatants are used to treat SH‐SY5Y treatment significantly recovers neurotoxicity from...
Abstract The microenvironment mediated by the microglia (MG) M1/M2 phenotypic switch plays a decisive role in neuronal fate and cognitive function of Alzheimer's disease (AD). However, impact metabolic reprogramming on microglial polarization its underlying mechanism remains elusive. This study reveals that cordycepin improved memory APP/PS1 mice, as well attenuated damage triggering MG‐M2 characterized increased OXPHOS glycolysis, rather than directly protecting neurons. Simultaneously,...
Scope We investigated the role of endoplasmic reticulum (ER) stress in protective effects EGCG against neuronal apoptosis Aβ 1‐42 ‐induced SH‐SY5Y cells and APP/PS1 transgenic mice. Methods results Cell viability (CCK8 assay), flow cytometry, Hoechst 33258 staining, immunohistochemistry, transmission electron microscopy (TEM), western blotting were used. prevented Aβ1‐42‐induced toxicity cells, increased cell viability, decreased a dose‐dependent manner. In subsequent mechanism study, it was...
Limitations in existing tools have hindered neuroscientists from achieving a deeper understanding of complex behaviors and diseases. The recent development optimization genetically encoded sensors offer powerful solution for investigating intricate dynamics such as calcium influx, membrane potential, the release neurotransmitters neuromodulators. In contrast, traditional methods are constrained by insufficient spatial and/or temporal resolution, low sensitivity, stringent application...
Early diagnosis of Alzheimer's disease (AD) is an urgent point for AD prevention and treatment. The biomarkers still remain indefinite. Based on the bioinformatics analysis mRNA differential expressions in brain tissues peripheral blood samples patients, we investigated target mRNAs that could be used as biomarker developed a new effective, practical clinical examination program.We compared mononuclear cells (PBMCs) expression dataset (GEO accession GSE4226 GSE18309) with tissue datasets...
Graphical Abstract PTAFR exacerbates the neuronal inflammatory microenvironment in AD brain.
Microglia-neuron crosstalk is critically involved in synaptic plasticity and degeneration by releasing diverse mediators Alzheimer's disease (AD). Therefore, determining contributors that modulate the systemic microenvironment essential. Cordycepin (CCS) a novel neuroprotective compound obtained from Cordyceps militaris. However, anti-AD efficacy potential mechanism of CCS treatment remain unclear. This study aimed to elucidate microglia-neuron symphony AD after explore possible mechanisms...
Rationale: Pancreatic encephalopathy (PE) refers to the abnormalities in mental status that complicate acute pancreatitis (AP). We report case of a patient who developed AP was complicated by PE and followed fatal cerebral hemorrhage. Patient concerns: A 41-year-old male with initially manifested subsequently Diagnoses: head computed tomography (CT) scan showed intracerebral hemorrhage located occipital lobe, an abdominal CT presented large amount peripancreatic fluid collections....
Cordycepin (Cor) is a potent bioactive constituent of Cordyceps militaris, which has been used as daily tonic food and herbal medicine in Asia. Cadmium (Cd) widespread neurotoxic environmental contaminant, it detected pollutant militaris. However, the potential effects Cor on Cd neurotoxicity remains unknown. This study aimed to investigate possible mechanisms Cd-induced cell preclinical models. It was observed that administration aggravated cognitive impairment mice, exerted synergistic...
Objective To describe the initial clinical experience of transvaginal NOTES-assisted laparoscopic nephrectomy. Methods From May to June 2010, 4 female patients with non-functioning kidney and 1 patient renal tuberculosis underwent The median age was 41 years (range 36 63). Three lesions were on right side, 2 left. After induction general anesthesia, positioned in lithotomy ipsilateral lumbar at 60° angle operating table. A 5 mm Trocar a 10 placed through umbilicus, for 30° laparoscope...
Objective To observe the effect of mature rehmannia extract on platelet derived growth factor (PDGF) and b-cell lymphoma-2 (bcl-2) 2 in myocardial tissue rats with infarction. Methods A total 30 healthy SD were randomly divided into blank group, model group glutinosa 10 each group. Myocardial infarction models established prepared Rehmannia The subcutaneously injected 4 g/kg. same volume saline. Once a day for 15 days. cardiac function was measured by echocardiography rats. HE...