To compare the effects of cannabis extract (CE), delta-9-tetrahydrocannabinol (THC), and placebo (PL) on appetite quality life (QOL) in patients with cancer-related anorexia-cachexia syndrome (CACS).Adult advanced cancer, CACS, weight loss (> or = 5% over 6 months), Eastern Cooperative Oncology Group (ECOG) performance status (PS) < 2 were randomly assigned (2:2:1) to receive CE (standardized for 2.5 mg THC 1 cannabidiol) (2.5 mg) PL orally, twice daily weeks. Appetite, mood, nausea...

Objective: Cannabis may alleviate some symptoms associated with multiple sclerosis (MS). This study investigated the effect of an orally administered standardized sativa plant extract in MS patients poorly controlled spasticity. Methods: During their inpatient rehabilitation programme, 57 were enrolled a prospective, randomized, double-blind, placebo-controlled crossover cannabis-extract capsules to 2.5 mg tetrahydrocannabinol (THC) and 0.9 cannabidiol (CBD) each. Patients group A started...

<b><i></i></b> The authors conducted a randomized, double-blind, placebo-controlled, twofold crossover study in 16 patients with MS who presented severe spasticity to investigate safety, tolerability, and efficacy of oral Δ⁹-Tetrahydrocannabinol (THC) <i>Cannabis sativa</i> plant extract. Both drugs were safe, but adverse events more common plant-extract treatment. Compared placebo, neither THC nor treatment reduced spasticity. worsened the participant's global impression.

BackgroundThe unfavourable side-effects of late-stage pancreatic cancer treatments call for non-toxic and effective therapeutic approaches. We compared the overall survival (OS) patients receiving an extract Viscum album [L.] (VaL) or no antineoplastic therapy.MethodsThis is a prospective, parallel, open label, monocentre, group-sequential, randomised phase III study. Patients with locally advanced metastatic pancreas were stratified according to binary prognosis index, composed tumour...

Background Cannabinoid-induced analgesia was shown in animal studies of acute inflammatory and neuropathic pain. In humans, controlled clinical trials with Delta-tetrahydrocannabinol or other cannabinoids demonstrated analgesic efficacy chronic pain syndromes, whereas the data were less conclusive. Therefore, aim this study to investigate effects oral cannabis extract two different human models hyperalgesia. Methods The authors conducted a double-blind, crossover 18 healthy female...

The treatment of cancer patients with mistletoe extract is said to prolong their survival and, above all, improve quality life. We studied whether the life advanced pancreatic could be improved by extract.An open, single-center, group-sequential, randomized phase III trial (ISRCTN70760582) was conducted. From January 2009 December 2010, 220 locally or metastatic who were receiving no further for other than best supportive care included in this trial. They stratified prognosis and randomly...

Abstract Background Cancer-related fatigue (CRF) and insomnia are major complaints in breast cancer survivors (BC). Aerobic training (AT), the standard therapy for CRF BC, shows only minor to moderate treatment effects. Other evidence-based treatments include cognitive behavioral therapy, e.g., sleep education/restriction (SE) mindfulness-based therapies. We investigated effectiveness of a 10-week multimodal program (MT) consisting SE, psycho-education, eurythmy- painting-therapy,...

Circulating tumor cells (CTCs) are detectable in peripheral blood of metastatic breast cancer patients (MBC). In this paper we evaluate a new CTC separation method based on combination anti-EpCAM- and anti-cytokeratin magnetic cell with the aim to improve detection low target antigen densities. Blood samples healthy donors spiked line HCC1937 were used determine accuracy precision method. 10 subjects examined specificity. counts 59 MBC measured prognostic value overall survival. Regression...

Fatigue is a very important factor determining the quality of life in patients with malignancies. Cancer fatigue occurs anaemia, during and after chemo- or radiotherapy advanced tumours. The Scale (CFS) three-dimensional inventory 15 items which was originally developed Japan. We present results validation study German version (CFS-D) this instrument. CFS-D administered to 114 participants matched-pair study. In total, 57 (41 women) had malignant conditions, were healthy volunteers....

Results of a Standardized Survey on the Medical Use Cannabis Products in German-Speaking Area The plant sativa has long history medical use treatment pain and spasms, promotion sleep, suppression nausea vomiting. However, early 70s cannabis was classified Narcotic Acts countries all over world as having no therapeutic benefit; therefore, it cannot be prescribed by physicians or dispensed pharmacists. In light this contradictory situation an increasing number patients practices...

Abstract Background To broaden the range of outcomes that we can measure for patients undergoing treatment oncological and other chronic conditions, aimed to validate a questionnaire measuring self-reported autonomic regulation (aR), i.e. characterise subject's functioning by questions on sleeping waking, vertigo, morningness-eveningness, thermoregulation, perspiration, bowel movements digestion. Methods We administered 440 participants (♀: N = 316, ♂: 124): 95 with breast cancer, 49...

Background . Osteosarcoma is a highly malignant bone tumour. After the second relapse, 12‐month postrelapse disease‐free survival (PRDFS) rate decreases below 20%. Oral Etoposide often used in clinical practice after surgery as an “adjuvant” outside any protocol and with only limited evidence of improved survival. Viscum album fermentatum Pini ( ) extract mistletoe plants grown on pine trees for subcutaneous (sc) injection immunomodulatory activity. Methods Encouraged by preliminary...

Abstract Background Equine sarcoids (ES) are the most common cutaneous tumors in equids. Systemic treatment options sparse. Subcutaneous (SC) injections of Viscum album extract (VAE) demonstrate efficacy as a systemic directed against ES. Objectives/Aim To critically assess therapeutic orally administered VAE. Animals Forty‐five ES‐affected, privately owned, 3–12 year‐old horses. Methods A 3‐armed randomized placebo‐controlled, double‐blinded study was conducted double‐dummy design. Horses...

HYPOTHESE: Cancer-related fatigue (CRF) and sleep disorders are some of the most wearing common symptoms in disease-free breast cancer patients (BC). Aerobic training (AT) is treatment with best available evidence, even though it seems to be insufficient regards improvements cognitive fatigue. We introduced a new multimodal therapy concept (MM) consisting psycho-, sleep-education approaches based on anthroposophic medicine such as eurythmy painting therapy.This pilot study will test...

Context: Cancer-related fatigue (CRF) is one of the most burdensome symptoms in breast cancer survivors (BCSs), accompanied by reduced health-related quality life (HRQOL). Objectives: This study investigated influence a multimodal therapy (MT; psychoeducation, eurythmy therapy, painting and sleep education/restriction), or combination (CT; MT plus aerobic training [AT]) on HRQOL BCS with chronic CRF comparison AT alone. Methods: One hundred twenty-six BCSs were included pragmatic...

Current inventories on quality of life used in oncology mainly focus functional aspects patients the context disease adaptation and treatments (side) effects (EORTC QLQ C30) or generically status common functions (Medical Outcome Study SF 36). Beyond circumscribed dimensions (i.e., physical, emotional, social, cognitive etc.), there is a lack which also address other relevant such as 'sense coherence' (SOC) cancer patients. SOC important because its potential prognostic relevance patients,...

Abstract Cancer-related fatigue (CRF) is a frequent long-term symptom in non-metastasized breast cancer patients (BC). This 4-year follow-up intended to compare the effects of 10-week multimodal therapy (MT: sleep education, psychoeducation, eurythmy- and painting therapy) combination [CT: MT plus aerobic training (AT)] AT-control. BC-patients were randomized or allocated by preference three arms comprehensive cohort study. Primary outcome was composite score including Pittsburgh Sleep...

Abstract Background Cancer Related Fatigue (CRF) and circadian rhythm have a great impact on the quality of life (HRQL) patients with breast (BC) colon cancer (CRC). Other patient related outcomes in oncology are measured by new instruments focusing adaptive characteristics such as sense coherence or self-regulation, which could be more appropriate prognostic tool than classical HRQL. The aim this study was to assess association autonomic regulation (aR) self-regulation (SR) survival....

Cutaneous squamous cell carcinoma (cSCC) and basal (BCC) belong to the group of keratinocyte carcinomas (KC). Actinic keratosis (AK) is a precursor lesion cSCC. The incidences cSCC, BCC, AK are currently strongly increasing. Different standard therapies exist for these conditions but not always applicable or successful. Hydrophilic Viscum album extracts have been used in anthroposophic cancer therapy since 1917. lipophilic extract (VALE) prepared by means supercritical CO2 extraction. This...

With increased life expectancy, the coexistence of functional impairment and multimorbidity can negatively impact quality coherence in geriatric individuals. The self-report 10-item Internal Coherence (ICS) measures how individuals cope with make sense disease-specific challenges. aim this study was to validate ICS a sample

The use of anthroposophic medicine (AM) is popular in Central Europe, especially German-speaking countries. Although these therapies are judged to be beneficial by many patients, there few data with regard the safety and efficacy pediatric oncology. Several theoretical concerns have been published tumor enhancement or promotion metastatic dissemination due mistletoe. To test indirect supportive treatment accompanying first-line children medulloblastoma this respect we performed a...