A5009886040- Pancreatic function and diabetes
- MicroRNA in disease regulation
- RNA Research and Splicing
- Neurogenesis and neuroplasticity mechanisms
- Growth Hormone and Insulin-like Growth Factors
- Genetics and Neurodevelopmental Disorders
- Genomics and Chromatin Dynamics
- Diabetes Management and Research
- RNA and protein synthesis mechanisms
- Hormonal Regulation and Hypertension
- Zebrafish Biomedical Research Applications
- Metabolism, Diabetes, and Cancer
- Congenital heart defects research
- Apelin-related biomedical research
- Diet, Metabolism, and Disease
- bioluminescence and chemiluminescence research
Charité - Universitätsmedizin Berlin
2024
Freie Universität Berlin
2024
Einstein Center for Neurosciences Berlin
2024
Humboldt-Universität zu Berlin
2024
University of Edinburgh
2020-2021
Discovery Centre
2020
Steno Diabetes Centers
1995
The nature and identity of the pancreatic beta-cell precursor has remained elusive for many years. One model envisions an early multihormonal that gives rise to both alpha- beta-cells other endocrine cell types. Alternatively, have been suggested arise late, directly from GLUT2- duodenal homeobox factor-1 (PDX1)-expressing epithelium, which also acinar cells during this stage. In study, we identified a subset PDX1+ epithelial are marked by expression Neurogenin3 (Ngn3). Ngn3, member basic...
The mouse homeodomain protein insulin promoter factor-1 (IPF-1) and the rat homologue somatostatin transactivating (STF-1) are involved in early pancreatic development have been implicated cell-specific regulation of insulin- somatostatin-gene expression mature islet beta- delta-cells. cell specificity IPF-1/STF-1 islets is, however, still unclear. Using antisera against recombinant IPF-1 STF-1 combination with hormones we find that all beta-cells monolayers newborn cells express STF-1, as...
Neural progenitors drive cellular diversification in the neocortex. Prolongation of their proliferative capacity and increased diversity underpins evolutionary expansion morphological complexity human Here, we investigate mechanisms that regulate maintenance highly early neural progenitor subtypes transition to subsequent limited during murine neocortical development. We identify DTX4, a Deltex family member, as an evolutionarily conserved molecular determinant identity mammalian DTX4...
During ontogeny, neural stem cells in the spinal cord cease production of neurons. Spinal injury re-initiates neurogenesis anamniotes (amphibians and fishes), but not mammals. It is unclear whether regenerative from progenitor simply depends on recapitulation developmental signals intracellular signal transduction or driven by mechanisms that are unique to regeneration. Using single cell RNAseq macrophages, as well type-specific manipulations, we provide evidence for a direct signalling axis...
Thyroid hormone receptor alpha (THRα) is a nuclear that binds triiodothyronine (T3) and acts as an important transcription factor in development, metabolism, reproduction. The coding gene, THRA, has two major splicing isoforms mammals, THRA1 THRA2, which encode THRα1 THRα1, respectively. better characterized isoform, transcriptional stimulator of genes involved cell metabolism growth. less well THRα2, lacks the Ligand Binding Domain (LBD) may act inhibitor activity. Thus, ratio to THRα2...
Thyroid hormone receptor alpha (THRα) is a nuclear that binds triiodothyronine (T3) and acts as an important transcription factor in development, metabolism, reproduction. The coding gene, THRA, has two major splicing isoforms mammals, THRA1 THRA2, which encode THRα1 THRα1, respectively. better characterized isoform, transcriptional stimulator of genes involved cell metabolism growth. less well-characterized THRα2, lacks the ligand-binding domain (LBD) may act inhibitor activity. Thus, ratio...