A5021391613- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Catalytic Alkyne Reactions
- Catalytic Cross-Coupling Reactions
- Spectroscopy and Quantum Chemical Studies
- Sulfur-Based Synthesis Techniques
- X-ray Diffraction in Crystallography
- History and advancements in chemistry
- Molecular spectroscopy and chirality
- Synthesis and Properties of Aromatic Compounds
- Supramolecular Chemistry and Complexes
- Luminescence and Fluorescent Materials
- Molecular Junctions and Nanostructures
- Organometallic Complex Synthesis and Catalysis
- Synthesis and characterization of novel inorganic/organometallic compounds
- Cyclopropane Reaction Mechanisms
- Advanced Chemical Physics Studies
- Organoboron and organosilicon chemistry
- Crystallization and Solubility Studies
- Molecular Spectroscopy and Structure
University of Hawaiʻi at Mānoa
2024
University of Hawaii System
2024
National Institute of Science Education and Research
2020-2022
Homi Bhabha National Institute
2022
1,4-cis-Disubstituted cyclic compounds play a pivotal role in pharmaceutical development, offering enhanced potency and bioavailability. However, their stereoselective modular synthesis remains long-standing challenge. Here, we report an innovative strategy for accessing these structures via mild conditions employing 1,3-dienes/alkyl(aryl)halides amines. This procedure exhibits wide substrate scope that tolerates various functional groups. The utility of this method is demonstrated the...
Palladium-catalyzed tandem activation and functionalization of readily accessible cyclopropanols have been demonstrated to access valuable conjugated enynes from 1,3-diynes with high stereo-selectivity.
Herein, nickel-catalyzed synthesis of polyarylcarbazole through sequential C-H bond activations has been described. Regioselective indole C2/C3 functionalization achieved in the presence C7-H, which is quite challenging. In addition, this approach also gives easy access to building a heteropolycyclic motif C6/C7 indoline. This methodology not limited aromatic internal alkynes as coupling partners; aliphatic have shown good tolerance. Notably, during optimization catalytic enhancement with...
First examples of racemization tetrahedral tetracoordinated centers <italic>via</italic> a planar transition state or an intermediate structure.
The transition state, a first-order saddle point on the potential energy surface, plays central role in understanding mechanism, dynamics, and rate of chemical reactions. However, we recently identified energetically accessible second-order saddles (SOS) certain reactions showed that SOS crucial dynamics [Pradhan et al., Phys. Chem. Phys., 2019, 21, 12837; Rashmi Regul. Chaotic Dyn., 2021, 26, 119]. In present work, investigated points thermal denitrogenation 1-pyrazoline using ab initio...
1,4-cis-disubstituted cyclic compounds play a pivotal role in pharmaceutical development, offering enhanced potency and bioavailability. However, their stereoselective modular synthesis remains long-standing challenge. Here, we report an innovative strategy for accessing these structures via mild conditions employing 1,3-dienes/alkyl(aryl)halides amines. This procedure exhibits wide substrate scope that tolerates various functional groups. The utility of this method is demonstrated the...
The quest for stabilizing planar forms of tetracoordinate carbon started five decades ago and intends to achieve interconversion between [R]- [S]-stereoisomers without breaking covalent bonds. Several strategies are successful in making the form a minimum on its potential energy surface. However, first examples systems where stereomutation is possible were reported only recently. In this study, possibility neutral dications simple hydrocarbons (cyclopentane, cyclopentene, spiropentane,...
We report here the first example of use 1,3-dialkynes in C-C bond activation with any metal. The regio- and stereo-selective synthesis 1,3-enynes from 1,3-diynes is demonstrated by palladium-catalyzed cyclo-propanol. Exclusive formation mono-alkenylated adduct was achieved eliminating possibility di-functionalization high stereo-selectivity. Indeed, this protocol worked very well electronically sterically diverse substrates. Several studies, including deuterium labeling experiments...
We report here the first example of use 1,3-dialkynes in C-C bond activation with any metal. The regio- and stereo-selective synthesis 1,3-enynes from 1,3-diynes is demonstrated by palladium-catalyzed cyclo-propanol. Exclusive formation mono-alkenylated adduct was achieved eliminating possibility di-functionalization high stereo-selectivity. Indeed, this protocol worked very well electronically sterically diverse substrates. Several studies, including deuterium labeling experiments...