A5077372008- DNA and Nucleic Acid Chemistry
- Crystallography and molecular interactions
- Protein Structure and Dynamics
- RNA and protein synthesis mechanisms
- Advanced Chemical Physics Studies
- History and advancements in chemistry
- Advanced Physical and Chemical Molecular Interactions
- Chemical Reaction Mechanisms
- Lipid Membrane Structure and Behavior
- Computational Drug Discovery Methods
- RNA modifications and cancer
- Organometallic Complex Synthesis and Catalysis
- Supramolecular Chemistry and Complexes
- Spectroscopy and Quantum Chemical Studies
International Institute of Information Technology, Hyderabad
2018-2021
First examples of racemization tetrahedral tetracoordinated centers <italic>via</italic> a planar transition state or an intermediate structure.
Energetically unfavorable Watson–Crick (WC)-like tautomeric forms of nucleobases are known to introduce spontaneous mutations, and contribute replication, transcription, translation errors. Recent NMR relaxation dispersion techniques were able show that wobble (w) G•U mispair exists in equilibrium with the short-lived, low-population WC-like enolic tautomers. Presently, we have investigated wG•U → reaction pathway using various theoretical methods: quantum mechanics (QM), molecular dynamics...
Understanding the structure-function relationships of RNA has become increasingly important given realization its functional role in various cellular processes. Chemical denaturation by urea been shown to be beneficial investigating stability and folding. Elucidation mechanism unfolding is for understanding folding pathways. In addition studying aqueous urea, it understand nature strength interactions building blocks RNA. this study, a systematic examination structural features energetic...
We for the first time shown that transition between (R) and (S) stereoisomers via a planar state or an intermediate structure without having to break bond is possible. Rigorous theoretical calculations have been used study this novel phenomenon characterize energetic, structure, dynamic kinetic properties.
We for the first time shown that transition between (R) and (S) stereoisomers via a planar state or an intermediate structure without having to break bond is possible. Rigorous theoretical calculations have been used study this novel phenomenon characterize energetic, structure, dynamic kinetic properties.
We for the first time shown that transition between (R) and (S) stereoisomers via a planar state or an intermediate structure without having to break bond is possible. Rigorous theoretical calculations have been used study this novel phenomenon characterize energetic, structure, dynamic kinetic properties.