A5019535147- Endoplasmic Reticulum Stress and Disease
- Schizophrenia research and treatment
- Genetics and Neurodevelopmental Disorders
- Asymmetric Synthesis and Catalysis
- Chemical Reaction Mechanisms
- Ubiquitin and proteasome pathways
- Neurogenesis and neuroplasticity mechanisms
- Autophagy in Disease and Therapy
- Diet and metabolism studies
- Protein Tyrosine Phosphatases
- Chemical Synthesis and Analysis
- Atherosclerosis and Cardiovascular Diseases
- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Cardiac Health and Mental Health
- 14-3-3 protein interactions
- Sirtuins and Resveratrol in Medicine
- Bioactive Compounds and Antitumor Agents
- Histone Deacetylase Inhibitors Research
- Protein Structure and Dynamics
- Cerebrovascular and Carotid Artery Diseases
- Plant tissue culture and regeneration
- Virus-based gene therapy research
- Neurological and metabolic disorders
- Axial and Atropisomeric Chirality Synthesis
Chiba Institute of Science
2012-2023
Chiba University
2015
Tokyo University of Agriculture and Technology
2008
University of Fukui
2007
Endoplasmic reticulum (ER) stress responses play an important role in neurodegenerative diseases. Sodium 4-phenylbutyrate (4-PBA) is a terminal aromatic substituted fatty acid that has been used for the treatment of urea cycle disorders. 4-PBA possesses vitro chemical chaperone activity and reduces accumulation Parkin-associated endothelin receptor-like receptor (Pael-R), which involved autosomal recessive juvenile parkinsonism (AR-JP). In this study, we show acids, including...
Neural stem cells (NSCs) play an essential role in development of the central nervous system. Endoplasmic reticulum (ER) stress induces neuronal death. After death, neurogenesis is generally enhanced to repair damaged regions. However, it unclear whether ER directly affects neurogenesis‐related processes such as differentiation and dendrite outgrowth. We evaluated outgrowth were regulated by HRD1, a ubiquitin ligase that was induced under mild conditions tunicamycin‐induced stress. Neurons...
Abstract In this study, we evaluated the chemical chaperone activity of synthetic 4-phenylbutyric acid (4-PBA) derivatives. These derivatives have a methoxy group at benzene ring and/or longer or shorter fatty portions. Several 4-PBA demonstrated higher antiaggregation than 4-PBA. Moreover, 4-(4-methoxyphenyl)butanoic (7b) showed protective effects against endoplasmic reticulum stress-induced neuronal cell death.
Patients with schizophrenia have increased risk of atherosclerotic diseases. It is already known that lifestyle-related disorders and the use antipsychotics are closely related progression atherosclerosis in psychiatric patients. Stroke as well coronary heart disease play an important role cause death Asia Japan. Thus, we studied prevalence cerebrovascular inpatients Japan using brain magnetic resonance imaging (MRI).This cross-sectional study was performed from January 2012 to December...
We discovered that a reagent comprising combination of PhBCl2 and nitriles was useful for syntheses both 3-acylindoles 1-(1H-indol-3-yl)alkylamine from indoles. The reaction proceeded selectively at the 3-position indoles providing in moderate to high yields on treatment with above reagent. Furthermore, provided corresponding amine products after intermediate imine reduced by NaBH3CN. These reactions under mild conditions are applicable formation functionalized 3-position.
For the first time, 14 N NMR spectra of a novel type heterocycles, dibenzo [a,d]cycl[2.2.3]azines were described.The chemical shifts are almost independent substituents at position 2. The correlations oxidation potentials with HOMO energies dibenzo[a,d]cycl[2.2.3]azines also offer very good correlation coefficients (r 2 >0.92) regardless calculation methods various levels.Thus, it was concluded that contribution unshared electron pairs central nitrogen to peripheral conjugation in this...
Regioselectivity in Mannich reaction of 4-, 3-, and 2-substituted phenols with typical heterocyclic amines are investigated under conditions developed by us.Phenol 4-alkyl, 4-chlorophenols the title predominantly gave corresponding 2-(aminomethyl)phenols, while 4methoxyphenol afforded, addition to mono(aminomethyl)phenols, a considerable amount bis adducts.Peculiarly enough, 3-methylphenol afforded 3-methyl-4-(aminomethyl)phenols whereas 2-methylphenol produced 2-methyl-6-(aminomethyl)phenols.
The pathogenesis of neurodegenerative diseases such as Alzheimer's and Parkinson's involves the aggregation denatured misfolded nascent proteins.Consequently, many pharmacological approaches have been developed to prevent protein aggregation.4-Phenylbutyric acid (4-PBA) is a chemical chaperone that shows potential candidate drug for treatment diseases.The main actions chaperones are amelioration unfolded proteins suppression their aggregation, which result in protective effects against...
Abstract Background One of the main causes death in psychiatric patients is cardiovascular diseases which are closely related with lifestyle-related diseases. Psychiatric disorders include schizophrenia and mood disorders, whose symptoms treatment medicines different, suggesting that they might have different metabolic disorders. Thus, we studied differences between Japan. Methods This cross-sectional study was performed from 2015 to 2017. Study participants were 189 Japanese hospitalized...
The results of X-ray analyses a novel type heterocycles, 2-benzoyl-and 1,3-dimethyldibenzo [a,d]cycl[2.2.3]azines were described, which offer further evidence for the 18π peripheral conjugate nature dibenzo-[a,d]cycl[2.2.3]azines.The molecules are essentially planer as is parent cycl[2.2.3]azine, but less strained.
Polypharmacy, common in patients with diabetes, may cause adverse drug reactions. The number of antidiabetic and non-antidiabetic drugs prescribed to different age groups remains unclear. aim this study was examine the class antidiabetics non-antidiabetics Japanese stratified by for reducing polypharmacy. This cross-sectional examined all prescriptions at 257 pharmacies Matsumotokiyoshi Holdings Japan from May 2018 March 2019. Total prescription numbers including were 263,915 study. Mean per...
It is well known that schizophrenic patients have high incidence of metabolic syndrome and life-style related diseases. There are reports the rates these diseases increased more in outpatients than inpatients, but also not different between both patient groups. These differences might be to length hospitalization. Hospitalization Japanese psychiatric about 300 days, much longer western countries (below 50 days). Therefore, we investigated lipid glucose metabolism transferred from...
The two strands of treatment available for coronary artery disease and associated pathologies are pharmaceutical physical. However, these treatments typically only too late to help tackle the early underlying processes. Better understanding processes is key development preventative solutions. One problems atherosclerosis, which when arteries lose elasticity. Associate Professor Seisuke Mimori, Department Clinical Medicine, Chiba Institute Science, Japan, examining biochemistry...
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