A5101667686- Drug Transport and Resistance Mechanisms
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Neuroscience and Neuropharmacology Research
- Genetic Mapping and Diversity in Plants and Animals
- Cannabis and Cannabinoid Research
- Pharmacogenetics and Drug Metabolism
- Schizophrenia research and treatment
- Endoplasmic Reticulum Stress and Disease
- Adipose Tissue and Metabolism
- CRISPR and Genetic Engineering
- Pharmacological Effects and Toxicity Studies
- Autophagy in Disease and Therapy
- Hormonal Regulation and Hypertension
- Neurofibromatosis and Schwannoma Cases
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Hernia repair and management
- Lipid metabolism and biosynthesis
- Bipolar Disorder and Treatment
- Gastric Cancer Management and Outcomes
- Diabetes and associated disorders
- Sleep and Wakefulness Research
- Tryptophan and brain disorders
Kawasaki Medical School
2022-2025
National Institute of Health Sciences
2023-2024
Kawasaki University of Medical Welfare
2021-2023
Chiba University
2015-2022
Keio University
2021
RELX Group (Netherlands)
2021
College of Charleston
2020
Toyama Prefectural Central Hospital
2016-2019
Tottori University
2018
Kumamoto University
2014-2018
Background and Purpose Phytocannabinoids in C annabis sativa have diverse pharmacological targets extending beyond cannabinoid receptors several exert notable anticonvulsant effects. For the first time, we investigated profile of phytocannabinoid cannabidivarin ( CBDV ) vitro vivo seizure models. Experimental Approach The effect (1–100 μM on epileptiform local field potentials LFPs induced rat hippocampal brain slices by 4‐aminopyridine (4‐ AP application or Mg 2+ ‐free conditions was...
Abstract RNA‐based therapeutics is a promising approach for curing intractable diseases by manipulating various cellular functions. For eliciting RNA (i.e., mRNA and siRNA) functions successfully, the in extracellular space must be protected it delivered to cytoplasm. In this study, development of self‐degradable lipid‐like material that accelerate collapse lipid nanoparticles (LNPs) release into cytoplasm reported. The self‐degradability based on unique reaction “Hydrolysis accelerated...
To date, anticonvulsant effects of the plant cannabinoid, cannabidivarin (CBDV), have been reported in several animal models seizure. However, these behaviourally observed not confirmed at molecular level. examine changes to epilepsy-related gene expression following chemical convulsant treatment and their subsequent control by phytocannabinoid administration, we evaluated CBDV (400 mg/kg, p.o.) on acute, pentylenetetrazole (PTZ: 95 i.p.)-induced seizures, quantified levels genes (Fos, Casp...
Abstract Endoplasmic reticulum (ER)-associated degradation (ERAD) is a mechanism by which unfolded proteins that accumulate in the ER are transported to cytosol for ubiquitin–proteasome-mediated degradation. Ubiquitin ligases (E3s) group of enzymes responsible substrate selectivity and ubiquitin chain formation. The purpose this study was identify novel E3s involved ERAD. Thirty-seven candidate genes were selected searches with RING-finger motifs transmembrane regions, major features ERAD...
Abstract Imeglimin is a new anti-diabetic drug commercialized in Japan (Twymeeg®) and has been drawing much attention diabetes research area as well clinical practice. In this study, we evaluated the effect of imeglimin on pancreatic β-cells. First, single-dose administration enhanced insulin secretion from β-cells decreased blood glucose levels type 2 diabetic db/db mice. addition, significantly augmented response to islets isolated non-diabetic db/m Second, during an oral tolerance test...
Deficiencies in social activities are hallmarks of numerous brain disorders. With respect to schizophrenia, withdrawal belongs the category negative symptoms and is associated with deficits cognitive domain. Here, we used N-methyl-D-aspartate receptor antagonist dizocilpine (MK-801) for induction rats assessed efficacy several atypical antipsychotics different pharmacological profiles as putative treatment. In addition, reasoned that marijuana constituent cannabidiol (CBD) may provide...
Endothelial damage mediated by mineralocorticoid receptor (MR) is an important factor in the development of atherosclerosis. Esaxerenone a highly selective drug that can specifically block MR activity. The aim this study to examine whether specific blocking signaling with esaxerenone exerts favorable effects on progression ApoE KO mice were used as model In addition non-diabetic model, we created diabetic using streptozotocin. These divided into control group and group....
Abstract Background Imeglimin is a new anti-diabetic drug which promotes insulin secretion from pancreatic β-cells and reduces resistance in target tissues. However, there have been no reports examining the possible anti-atherosclerotic effects of imeglimin. In this study, we investigated imeglimin using atherosclerosis model ApoE KO mice treated with streptozotocin (STZ). Methods were divided into three groups: first group was normoglycemic without injecting STZ (non-DM group, n = 10)....
SUMMARY 1. We have confirmed the Diabetes Mellitus OLETF type I ( Dmo1 ) effect on hyperphagia, dyslipidaemia and obesity in Otsuka Long‐Evans Tokushima Fatty (OLETF) strain. The critical interval was narrowed down to 570 kb between D1Got258 p162CA1 by segregation analyses using congenic lines. 2. Within region of locus, we identified G‐protein‐coupled receptor gene GPR10 as causative mutated ATG translation initiation codon is changed into ATA this strain and, so, unavailable for...
P-glycoprotein (P-gp), encoded by the <i>MDR1</i> gene in humans and <i>Mdr1a</i>/<i>1b</i> genes rodents, is expressed numerous tissues performs as an efflux pump to limit distribution absorption of many drugs. Owing species differences P-gp between it difficult predict impact on pharmacokinetics tissue substrates from results animal experiments. Therefore, we generated a novel humanized mouse model using artificial chromosome (MAC) vector [designated human MDR1-MAC (hMDR1-MAC) mice]. The...
Abstract Aim Tirzepatide, a dual agonist of glucagon‐like peptide receptor and glucose‐dependent insulinotropic polypeptide receptor, is expected to exhibit high clinical efficacy in obese type 2 diabetic patients. We evaluated the effects tirzepatide on pancreatic β‐cells liver, an insulin‐target organ, mouse model diabetes mellitus. Materials Methods Obese db/db mice (BKS.Cg−/+ Leprdb/+ Leprdb/Jcl*) were used this study. Starting at 7 weeks age, treated with (30 nmol/kg, subcutaneous...
Abstract Effects of combination therapy dipeptidyl peptidase-4 (DPP-4) inhibitor and sodium-glucose co-transporter 2 (SGLT2) on β-cells are still unclear, although agent these two drugs has become common in clinical practice. Therefore, we aimed to elucidate the effects DPP-4 and/or SGLT2 β-cell mass function compared their between an early advanced phase diabetes. We used 7-week-old db/db mice as 16-week-old treated them for weeks with oral administration linagliptin, empagliflozin,...
Sarcopenia is widely believed to be linked poorer outcomes in inpatient rehabilitation. This study aimed assess the impact of sarcopenia on functional and dietary intake during hospitalization adults undergoing convalescent We conducted a retrospective cohort analysis at single rehabilitation institution. The Asian Working Group Consensus Criteria for was used diagnose. Functional Independence Measure (FIM) score hospital discharge measure primary outcome. Energy protein intakes were...
Rifampicin (RIF), a typical ligand of human pregnane X receptor (PXR), powerfully induces the expression cytochrome P450 3A4 (CYP3A4) in humans. Although it is thought that RIF not rodent PXR, treatment with high-dose (e.g. more than 20 mg/kg) increases CYP3A mouse liver. In this study, we investigated whether induction by liver mediated via indirect activation PXR (mPXR). The results showed increased CYP3A11 and other PXR-target genes wild-type mice but PXR-knockout mice. However, reporter...
P-Glycoprotein (P-gp), encoded by the MDR1 (ABCB1) gene in humans and Mdr1a Mdr1b genes rodents, is a member of superfamily ATP-binding cassette transporters. Since P-gp constitutively expressed numerous tissues exhibits broad specificity substrate recognition, it can play crucial role limiting absorption distribution xenobiotics decreasing their intracellular accumulation. The expression regulated various nuclear receptors such as pregnane X receptor (PXR). Although characterization...
Proton pump inhibitors (PPIs) are frequently prescribed to patients with gastroesophageal reflux disease; however, the number of bone fractures reportedly increased in these patients. Although PPIs have been shown inhibit resorption by osteoclasts, effect on skeletal metabolism remains controversial. The aim present study was determine PPI rabeprazole using gastrectomized rats. Male Wistar rats were divided into four groups: i) Sham‑surgery (n=15); ii) total gastrectomy (TG) control (n=20);...