A5022222284- Marine and environmental studies
- Aquatic and Environmental Studies
- Genetics and Neurodevelopmental Disorders
- Oceanographic and Atmospheric Processes
- Neuroscience and Neuropharmacology Research
- Epigenetics and DNA Methylation
- Geological Studies and Exploration
- RNA modifications and cancer
- Environmental and Biological Research in Conflict Zones
- Geology and Paleoclimatology Research
- Neuroendocrine regulation and behavior
- Peatlands and Wetlands Ecology
- Biochemical effects in animals
- Remote Sensing and Land Use
- Methane Hydrates and Related Phenomena
- Axon Guidance and Neuronal Signaling
- Soil and Environmental Studies
- Mitochondrial Function and Pathology
- Chemical Reactions and Isotopes
- Environmental Changes in China
- Spaceflight effects on biology
- Epilepsy research and treatment
- Coastal and Marine Management
- Microtubule and mitosis dynamics
- Legal, Health, Environmental and COVID-19 Challenges
N. I. Lobachevsky State University of Nizhny Novgorod
2023-2025
Moscow State University
2024
Lomonosov Moscow State University
2024
Russian Academy of Sciences
2000-2023
Tomsk National Research Medical Center
2023
Institute of Water Problems
1997-2011
Abstract SPOUT1/CENP-32 encodes a putative SPOUT RNA methyltransferase previously identified as mitotic chromosome associated protein. depletion leads to centrosome detachment from the spindle poles and misalignment. Aided by gene matching platforms, here we identify 28 individuals with neurodevelopmental delays 21 families bi-allelic variants in detected exome/genome sequencing. Zebrafish spout1/cenp-32 mutants show reduction larval head size concomitant apoptosis likely altered cell cycle...
Animal models of epilepsy are valuable tools for studying the pathogenesis disease, developing new methods treatment, searching anticonvulsants and evaluating their effectiveness. Rodents, such as rats mice, most popular subjects research due to similarity human rodent brain structure. Recent studies include other model species dogs, cats, primates, well non-mammals zebrafish, fruit flies, leeches planarians. This review discusses use animal in analyzes advantages limitations. The...
SPOUT1/CENP-32 encodes a putative SPOUT RNA methyltransferase previously identified as mitotic chromosome associated protein. depletion leads to centrosome detachment from the spindle poles and misalignment. Aided by gene matching platforms, we 24 individuals with neurodevelopmental delays 18 families bi-allelic variants in detected exome/genome sequencing. Zebrafish spout1/cenp-32 mutants showed reduction larval head size concomitant apoptosis likely altered cell cycle progression. In vivo...
The article provides a unique author’s methodology of calculating compensation for costs connected with the Baltic Sea contamination. It is based on studying contribution all countries basin to anthropogenic burden ecosystems sea. Contribution each country degradation ecosystem was estimated and this basis general anti-rating impact made up, as well by factors eutrophication contamination oil products. With help data conclusion that shall pay certain amount money restore degraded according...
The mechanisms of epileptogenesis after brain injury, ischemic stroke, or tumors have been extensively studied. As a result, many effective antiseizure drugs developed. However, there are still patients who resistant to therapy. molecular and genetic bases regarding such drug-resistant seizures poorly elucidated. In cases, heavy instigated by development malformations often caused gene mutations. Such can be demonstrated in mouse models generating mutant strains. One the most potent mutagens...
The aim of the work is to determine criteria marine shallow-water ecosystem stability using Northern region Caspian Sea as a case study. For each 260 reference points, we received data on 76 parameters, including physical-geographical, hydrochemical, and hydrobiological characteristics that have been analyzed by method principle components. analyzes these allowed us reveal evaluate principal geoecological factors influence distribution Acipenseridae in top level ecosystem’s trophic chain....
Heat shock proteins (HSPs) make up a large family of molecular chaperones, recognized for their role in protein maturation, refolding, and degradation. HSP70 was shown to promote cell survival during several pathological processes the brain, such as stroke, neurodegenerative diseases, epilepsy, trauma [1]. In addition, HSPs serve proper embryonic postnatal development many organ systems, central nervous system [2]. demonstrate specific expression patterns throughout system, notably crucial...
Epilepsy is a chronic neurological disorder marked by recurring seizures and associated dysfunctions of motor, sensory, autonomic, mental functions resulting from excessive electrical activity neurons. Identification characterization the mutations that cause this pathology are essential for understanding mechanisms control epileptogenesis. The aim study to characterize S8-3 mutant mice strain, which shows induced epileptiform in response audiogenic stimulation. Mutant strains were acquired...
This paper discusses possible consequences of changes in the Volga-Caspian aquatic ecosystems resulting from climate change according to data scenarios Worldwide Meteorological Organization. Main hydro-ecological factors stability Northern Caspian Sea have been determined. It appears that ecosystem is primarily affected by natural conditions. essential model riparian processes and winter regime reservoirs develop strategies for mitigation negative impacts change. Such measures may include...
Fusarium, Penicillium, Trichoderma, Verticillium, species of the genus Aspergillus dominate.The proportion representatives Penicillium significantly increases, and melanin-containing fungi, as indicators soil general toxicity, increases to 8-15 % depending on growing season.
Because of the difficulties in study coastal zone, a search for indirect interpretation keys marine landscapes is extremely timely. This paper describes remote sensing program based on recognition, identification (classification), and mapping bottom natural complexes (BNC) shallow parts Sea Japan, extending distance 60 km along coast. Indirect were identified BNC zone sea, which include type shoreline relief, configuration, river runoff. Translated by Edward Torrey, Alexandria VA 22308 from:...