Long Li

ORCID: 0000-0002-7365-2494
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About
Contact & Profiles
Research Areas
  • Micro and Nano Robotics
  • Lipid Membrane Structure and Behavior
  • Characterization and Applications of Magnetic Nanoparticles
  • Molecular Communication and Nanonetworks
  • Cell Adhesion Molecules Research
  • Microfluidic and Bio-sensing Technologies
  • Non-Invasive Vital Sign Monitoring
  • Metal and Thin Film Mechanics
  • Electrohydrodynamics and Fluid Dynamics
  • ECG Monitoring and Analysis
  • RNA Interference and Gene Delivery
  • Nanoparticle-Based Drug Delivery
  • thermodynamics and calorimetric analyses
  • Spectroscopy Techniques in Biomedical and Chemical Research
  • Force Microscopy Techniques and Applications
  • Phagocytosis and Immune Regulation
  • Heart Rate Variability and Autonomic Control
  • Erythrocyte Function and Pathophysiology
  • Gold and Silver Nanoparticles Synthesis and Applications

Institute of Mechanics
2021-2025

Chinese Academy of Sciences
2021-2025

State Key Laboratory of Nonlinear Mechanics
2021-2025

Nanjing University
2023-2024

University of Chinese Academy of Sciences
2024

Zhejiang University of Technology
2022

Gaining insight into osmotic pressure and its biological implications is pivotal for revealing mechanisms underlying numerous fundamental processes across scales will contribute to the biomedical pharmaceutical fields. This review aims provide an overview of current understanding, focusing on two central issues: (i) how determine theoretically (ii) affects important activities. More specifically, we discuss representative theoretical equations models different solutions, emphasizing their...

10.3390/ijms25063310 article EN International Journal of Molecular Sciences 2024-03-14

For precise bone formation, osteoblasts need to accurately migrate specific sites guided by various biochemical and mechanical cues. During this migration, fluctuations in extracellular osmolarity may arise from shifts the surrounding fluid environment. However, as a main regulator of cell morphology function, whether change affect osteoblast migration remains unclear. Here, we provide evidence showing that changes significantly impact with hypotonic environment enhancing it while hypertonic...

10.1038/s42003-025-07946-8 article EN cc-by-nc-nd Communications Biology 2025-03-29

Abstract Developing physical methods to modulate biomolecular clusters and condensates on cell membranes is of great importance for understanding physiological pathological processes as well stimulating novel therapeutic strategies. Here, we propose an effective means control receptor condensation the membrane via specific adhesion a supported lipid bilayer (SLB) with nanoscale topography. The mediated by receptors in that bind their ligands anchored SLB. Using Monte Carlo simulations...

10.1038/s42005-024-01670-1 article EN cc-by Communications Physics 2024-06-01

Nanoparticles (NPs) have been widely applied as drug carriers in delivery, due to their unique physical and structural properties. To achieve the delivery purpose, receptor-mediated endocytosis is a primary explored mechanism internalize NPs into tumor cells. During process, properties of NPs, including size, shape, surface functionality, play an important role determining final efficacy. Many these NP extensively individually. However, multiple naturally interplay with each other process...

10.3390/cryst11070728 article EN cc-by Crystals 2021-06-24

Abstract Artificial micro/nanomotors using active particles hold vast potential in applications such as drug delivery and microfabrication. However, upgrading them to micro/nanorobots capable of performing precise tasks with sophisticated functions remains challenging. Bubble microthruster (BMT) is introduced, a variation the bubble‐driven microrobot, which focuses energy from collapsing microbubble create an inertial impact on nearby target microparticles. Utilizing ultra‐high‐speed...

10.1002/advs.202403867 article EN cc-by Advanced Science 2024-05-22

The specific binding of the ubiquitous 'marker self' protein CD47 to SIRPα anchored in macrophage plasma membrane results inhibition engulfment 'self' cells by macrophages and thus constitutes a key checkpoint our innate immune system. Consequently, CD47-SIRPα complex has been recognized as potential therapeutic target cancer inflammation. Here, we introduce lattice-based mesoscale model for biomimetic system studied recently fluorescence microscopy experiments where GFP-tagged proteins on...

10.3390/membranes13110871 article EN cc-by Membranes 2023-11-02

Artificial micro/nanomotors utilizing active particles exhibit enormous potential in applications such as drug delivery and microfabrication. However, their substantial upgrade to micro/nanorobots capable of executing precise tasks with sophisticated functions remains a significant challenge. In this paper, we develop bubble microthruster (BMT) – new variation on the driven microrobot that focuses energy from collapsed microbubble create hydrodynamic jet exert inertial impact nearby...

10.26434/chemrxiv-2023-z7jw9 preprint EN cc-by-nc-nd 2023-09-22
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