A5062442083- Bone Tissue Engineering Materials
- Microbial Metabolic Engineering and Bioproduction
- biodegradable polymer synthesis and properties
- Electrospun Nanofibers in Biomedical Applications
- Enzyme Catalysis and Immobilization
- Graphene and Nanomaterials Applications
- Dental Implant Techniques and Outcomes
- Microstructure and Mechanical Properties of Steels
- Muscle metabolism and nutrition
- Electromagnetic Effects on Materials
- Diet and metabolism studies
- Dental materials and restorations
- Advanced MIMO Systems Optimization
- Microstructure and mechanical properties
- Human-Automation Interaction and Safety
- Advanced Wireless Network Optimization
- Muscle Physiology and Disorders
- Atherosclerosis and Cardiovascular Diseases
- Viral Infectious Diseases and Gene Expression in Insects
- Smart Grid and Power Systems
- Microplastics and Plastic Pollution
- Metabolism and Genetic Disorders
- Amino Acid Enzymes and Metabolism
- Older Adults Driving Studies
- Microbial Fuel Cells and Bioremediation
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Stomatology Hospital
2025
National Clinical Research
2025
Tsinghua University
2011-2024
Peking University
2022-2024
National Clinical Research Center for Digestive Diseases
2024
Jiangnan University
2024
Tongji University
2024
King University
2024
Heilongjiang Bayi Agricultural University
2023
Repairing large tumor-related bone defects remains a difficult clinical problem because of the significant risk locoregional relapse after surgical curettage. In this study, composite scaffold nano-hydroxyapatite (nHA) and reduced graphene oxide (rGO) sheets was fabricated by self-assembly, 20 wt% nHA-rGO sheet solution formed most stable hydrogel. vitro, scaffolds killed all but 8% osteosarcoma cells (MG-63) under 808 nm near-infrared laser irradiation for min. SEM images live/dead staining...
Abstract Genetically programmed circuits allowing bifunctional dynamic regulation of enzyme expression have far-reaching significances for various bio-manufactural purposes. However, building a bio-switch with post log-phase response and reversibility during scale-up bioprocesses is still challenge in metabolic engineering due to the lack robustness. Here, we report robust thermosensitive that enables stringent bidirectional control gene over time levels living cells. Based on bio-switch,...
Hydrogels are used in vascular tissue engineering because of their good biocompatibility. However, most natural hydrogels exhibit high swelling ratio, poor mechanical stability, and low durability, which key limitations for wider applications. Amphiphilic fatigue-resistant organohydrogels were fabricated here via the click chemical reaction unsaturated functional microbial polyhydroxyalkanoates polyethylene glycol diacrylate a combination two-dimensional material graphdiyne. These maintained...
Peripheral nerve defects are a worldwide problem, and autologous transplantation is currently the gold-standard treatment for them. Tissue-engineered (TEN) grafts widely considered promising methods same, have attracted much attention. To improve repair, incorporation of bionics into TEN has become focus research. In this study, novel bionic graft with biomimetic structure composition designed. For purpose, chitin helical scaffold fabricated by means mold casting acetylation using chitosan...
To treat large-scale wounds or chronic ulcers, it is highly desirable to develop multifunctional wound dressings that integrate antibacterial and angiogenic properties. While many biomaterials have been fabricated as for skin regeneration, few reports addressed the issue of complete regeneration due lack vasculature hair follicles. Herein, an instructive poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P34HB) fibrous dressing integrates ciprofloxacin (CIP) pro-angiogenic dimethyloxalylglycine...
3D-printed scaffolds of polyhydroxyalkanoate (PHA) are functionalized using polydopamine (PDA)-mediated recombinant human bone morphogenetic protein-2 (BMP2) to generate high osteoinductive activity for in vivo regeneration.
Abstract Bacterial infection and mismatched mechanical properties are important factors that increase the risk of dental implant failure. However, zirconium (Zr)‐based bulk metallic glasses (BMGs) can have both high strength low modulus, as well good biocompatibility, due to their unique atomic arrangement structure. Based on these common characteristics, different elemental compositions endow zirconium‐based amorphous alloys with properties. Here, we present a Zr‐based BMG containing silver...
Abstract Industrial biotechnology aims to solve the challenges of petroleum‐based production using microorganisms as catalysts. However, current industrial suffers from high energy and fresh water consumption well difficult downstream purification. In addition, most are not resistant other microbial contaminations, this seriously compromises process effectiveness economy. The recently proposed “next‐generation biotechnology” employs contamination microorganisms, including alkaliphilic,...
Fluorescent materials play an important role in biomedical fields. However, the main types of fluorescent suffer from several disadvantages especially biotoxicity, which largely restrict its wider applications biological In this study, a highly efficient rare-earth-modified material was successfully designed and fabricated based on polyhydroxyalkanoates, are known as biodegradable biocompatible materials. A new Functional-PHA polymer microbially synthesized by engineered Halomonas...
To study the effects of pulsed magnetic fields different intensities on dislocation density, residual stress, and hardness Cr4Mo4V steel, treatment is conducted at 0, 1.0, 1.3, 1.5, 2.0, 2.5 T. The density stress are measured using Electron Backscatter Diffraction (EBSD) X-ray technique, respectively. results reveal compressive decrease lower such as 1.0 T 1.3 T, while they increase higher 2.0 average value kernel averaged misorientation (KAM) about 10.4% 15.8%, respectively, 5.88% 18.2%,...
In this work, the influences of a magnetic field 2.4 T on macro residual stress and status structural defects, including grain boundaries, dislocations Fe-rich clusters Ti-6Al-4V were investigated by X-ray Diffraction (XRD), Electron Backscatter (EBSD) measurement. The XRD test results show that applied can cause relaxation homogenization stress. maps Kernel Average Misorientation (KAM) values obtained EBSD tests present significant dislocation multiplication caused field, rise density was...
Background: This study was aimed to investigate the effect of three dimensional (3D)printed poly lactide-co-glycolide (PLGA) scaffolds combined with Gly-Phe-Hyp-Gly-Arg (GFOGER) and bone morphogenetic protein 9 (BMP-9) on repair large defects. Methods: 3D printing method used produce PLGA scaffolds, sample viewed by both optical microscopy SEM, XRD analysis, water absorption compressive strength etc. The rabbits were divided into six groups randomly defect models constructed (6 mm in...