A5005712921- Nanoparticle-Based Drug Delivery
- Distributed and Parallel Computing Systems
- Distributed systems and fault tolerance
- Formal Methods in Verification
- Advanced Software Engineering Methodologies
- Logic, programming, and type systems
- Service-Oriented Architecture and Web Services
- Parallel Computing and Optimization Techniques
- Real-Time Systems Scheduling
- Evolution and Genetic Dynamics
- Peroxisome Proliferator-Activated Receptors
- Gene expression and cancer classification
- Cancer Research and Treatments
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Barrier Structure and Function Studies
- Inflammatory mediators and NSAID effects
- Bioinformatics and Genomic Networks
- Animal Behavior and Reproduction
- Asian Studies and History
- Evolutionary Algorithms and Applications
- Language and cultural evolution
- Ocean Acidification Effects and Responses
- Chemokine receptors and signaling
- Polymer Surface Interaction Studies
Radboud University Nijmegen
2023-2024
University of Twente
2023
University Medical Center Groningen
2014-2021
University of Groningen
2003-2021
Hudson Institute
2018
Université Paris Cité
2018
Délégation Paris 7
2018
Institut Jacques Monod
2018
Merck Institute for Science Education
2018
John Wiley & Sons (United States)
2018
Transport of therapeutics across the blood–brain barrier (BBB) is a fundamental requirement for effective treatment numerous brain diseases. However, most (>500 Da) are unable to permeate through BBB and do not achieve therapeutic doses. Nanoparticles (NPs) being investigated facilitate drug delivery brain. Here, we investigate effect nanoparticle stiffness on NP transport an in vitro model. To this end, fluorescently labeled poly(N-isopropylmethacrylamide) (p(NIPMAM)) nanogels' was varied...
A mild, robust and fast method to form nano-sized biodegradable polymersomes is described.
The delivery of therapeutics to the brain is greatly hampered by blood-brain barrier (BBB). use nanoparticles that can cross BBB via process receptor-mediated transcytosis at endothelial cells seems a promising strategy transport into brain. To screen for suitable nanocarriers, and study transcytosis, cultured polarized monolayer microvascular on an extracellular matrix-coated porous membrane filter widely used as in vitro model. However, due adhesion numerous types within pores, such model...
15-deoxy-delta-12,14-prostaglandin-J2 (15d-PGJ2), an arachidonic metabolite and a natural PPARγ agonist, is known to induce apoptosis in tumor cells. In this study, we investigated new therapeutic potentials of 15d-PGJ2 by determining its anticancer effects wild-type doxorubicin-resistant ovarian carcinoma Despite high expression resistance-inducing genes like MDR1, Bcl2 Bcl-xl, strongly induced (A2780/AD) cells similar the (A2780). This was found be related caspase-3/7- NF-κB pathways but...
Abstract The polarized architecture of epithelium presents a barrier to therapeutic drug/gene carriers, which is mainly due limited (apical) internalization the carrier systems. bacterium Pseudomonas aeruginosa invades epithelial cells by inducing production apical phosphatidylinositol-3, 4, 5-triphosphate (PIP3), results in recruitment basolateral receptors membrane. Since are known for gene delivery vectors, PIP3 may improve such vectors into cells. and nucleic acids were complexed...
Abstract This study investigates the intricate connections between relational wellbeing and individual resilience, through family community protective factors. As such, we aim to bridge an existing gap in resilience literature by examining elements that contribute from a perspective random sample of slum dwellers Indonesia. To address this research gap, adopted White’s conceptualisation integrated Benard’s on applied them using established measures assess general population living areas...
Social scientists have long considered place attachment to be an important factor in promoting environmentally sustainable behaviours among individuals. Raymond and colleagues developed a five-factor measure, comprising dependence, nature attachment, family bonding, friendship that encompasses most of the differentiations made has been amply tested for validity reliability. However, bulk these confirmatory studies conducted Western societies, neglecting people Global South particularly...
Article Free Access Share on A software architecture for distributed control systems and its transition system semantics Authors: Marcello M. Bonsangue Department of Computer Science, Leiden University, The Netherlands NetherlandsView Profile , Joost N. Kok Maarten Boasson Hollandse Signaalapparaten B.V., Edwin de Jong Authors Info & Claims SAC '98: Proceedings the 1998 ACM symposium Applied ComputingFebruary Pages 159–168https://doi.org/10.1145/330560.330664Online:27 February...
Abstract The implementations of Algol 60, FORTRAN, Pascal and 68 provided on the CDC Cyber 73 Stichting Academisch Rekencentrum Amsterdam are compared both qualitative quantitative aspects. This paper concentrates those aspects which likely to be interest language designers implementers, users other computer systems.
SPLICE is an industrially developed and applied software architecture for large-scale distributed embedded systems. The key feature of asynchronous communication between processes. characteristics systems built with include dynamic data distribution, fault-tolerance, real-time performance. objective the work presented in this paper was to use a formal model reason about behaviour support design process system decomposition refinement. We formalize using algebra called Process Algebra. This...
This paper presents a formal method for requirements specification and analysis. Using this some techniques step-wise refinement are studied. During the early phases of system development, where exact yet unclear these allow to write incomplete global specifications, which during successive steps can be refined completed. At each step supports analysis specification. In particular two abstraction studied: nondeterminism uninterpreted symbols. These explored using realistic case study, that...
The QuakeSim Project improves understanding of earthquake processes by integrating model applications and various heterogeneous data sources within a web services environment. project focuses on the cycle related crustal deformation. Spaceborne GPS Interferometric Synthetic Aperture provide information near-term deformation, while paleoseismic geologic longer-term fault processes. These are integrated into QuakeSim's QuakeTables database accessible users or applications. An increasing amount...
Article Free Access Share on Semantical aspects of an architecture for distributed embedded systems Authors: Roel Bloo Eindhoven University Technology, Eindhoven, The Netherlands NetherlandsView Profile , Jozef Hooman Nijmegen, Edwin de Jong Hollandse, Signaalapparaten B.V., Hengelo, Authors Info & Claims SAC '00: Proceedings the 2000 ACM symposium Applied computing - Volume 1March Pages 149–155https://doi.org/10.1145/335603.335731Published:19 March 2000Publication History...
Presents a formal object model in which the replication of components and recovery from crash failures are transparent. The is based on concurrently executing objects that interact through shared data space. We formally define by denotational semantics possible behaviours an defined corresponding set state transition traces. Using semantics, we derive some fundamental algebraic properties reflect transparent recovery.
No abstract available.