Signe Emilie Dannulat Frazier

ORCID: 0000-0002-7391-4773
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About
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Research Areas
  • Circadian rhythm and melatonin
  • Neuropeptides and Animal Physiology
  • Regulation of Appetite and Obesity

Novo Nordisk (Denmark)
2022

Restoring the control of food intake is key to obesity management and prevention. The arcuate nucleus (ARC) hypothalamus extensively being studied as a potential anti-obesity target. Animal studies showed that neuropeptide FF (NPFF) reduces by its action in Y (NPY) neurons hypothalamic ARC, but detailed mode observed human missing, due lack human-neuron-based model for pharmacology testing. Here, we validated utilized human-neural-stem-cell-based (hNSC) ARC test effects NPFF on cellular...

10.3390/ijms23063260 article EN International Journal of Molecular Sciences 2022-03-17
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