A5028809386- Alzheimer's disease research and treatments
- Supramolecular Self-Assembly in Materials
- Plant responses to water stress
- Plant Stress Responses and Tolerance
- Plant nutrient uptake and metabolism
- Heavy Metal Exposure and Toxicity
- Agricultural Economics and Practices
- Lipid Membrane Structure and Behavior
- Bioenergy crop production and management
- Aluminum toxicity and tolerance in plants and animals
- Pharmacogenetics and Drug Metabolism
- Livestock Management and Performance Improvement
- FOXO transcription factor regulation
- Molecular Sensors and Ion Detection
- Advanced oxidation water treatment
- CRISPR and Genetic Engineering
- Drug Transport and Resistance Mechanisms
- RNA modifications and cancer
- Carcinogens and Genotoxicity Assessment
- Chromosomal and Genetic Variations
- Protein Structure and Dynamics
- Electrochemical Analysis and Applications
- TiO2 Photocatalysis and Solar Cells
- Nanomaterials for catalytic reactions
- Seed Germination and Physiology
Queen Mary University of London
2024-2025
Quaid-i-Azam University
2020-2023
Purdue University West Lafayette
2020
University of Karachi
2016-2019
COMSATS University Islamabad
2019
Cancer Genetics (United States)
2019
Alzheimer's disease (AD) is linked with the self-association of amyloid-β peptide (Aβ) into oligomers and fibrils. The brain a lipid rich environment for Aβ to assemble, while membrane composition varies in an age dependent manner, we have therefore monitored influence bilayer on kinetics Aβ40 fibril assembly. Using global-fitting models formation kinetics, show that microscopic rate constant primary nucleation influenced by variations phospholipid composition. Anionic phospholipids...
Abstract The p3 peptides, Aβ 17-40/42 , are a common alternative cleavage product of the amyloid precursor protein, and found in diffuse deposits Alzheimer’s Down Syndrome brains. peptides have been mis-named ‘non-amyloidogenic’. Here we show 40/42 rapidly form fibrils, with kinetics dominated by secondary nucleation. Importantly, cross-seeding experiments, full-length induces strong nucleation between peptides. interaction is highly specific, occurs only when C-terminal residues matched. We...
Aim: In this study, we evaluated the effect of selected polymorphisms mitochondrial unfolded protein response (UPRmt) pathway in 500 head and neck cancer (HNC) patients healthy controls from Pakistan. Materials & methods: The experiments were conducted using tetra-ARMS PCR followed by DNA sequencing. Results: Multivariate analysis showed that AA genotype rs3782116 fivefold, GG rs6598072 approximately twofold CC rs4946936 TT rs12212067 increased risk HNC. Furthermore, haplotype certain...
ABSTRACT Small prefibrillar structures of the amyloid-β peptide (Aβ) are believed to be central cytotoxicity in Alzheimer’s disease, most common form dementia. A snapshot these assemblies has therefore been characterized using a combination cryo-ET and cryo-EM single particle analysis. This facilitated an understanding relationship between, oligomers, curvilinear protofibrils annular assemblies. highly consistent diameter for all oligomers 28 Å, indicates that simply structural extensions...
This article discusses the titanium (Ti)-based permanganate advanced catalytic oxidation process (ACOP) for possible recovery of thousands tons dye wastewater. The heterogeneous catalyst TiO2 in solid state employed liquid phase reaction mixture with and potassium was recovered reused several times reproducible results. kinetics were examined at various operational parameters like effect dyes, oxidants, amount catalysts, acids, temperature, organic inorganic additives used textile industry....
Background: Lignin and cellulose, organic constituents of the plant or plant-based material not commonly used for feeding purpose are referred as Biomass. Patents suggest that this can be best resource renewable energy. Vesicular Arbuscular Mycorrhizae (VAM) fungi play an effective role in biomass manufacturing through activated metabolism under dual symbiosis. During C acclimatization, mycorrhizal inoculated plants existent greater number leaves with a height compared to non-mycorrhizal...
Breast cancer (BC) continues to be the most common in women worldwide. Since estrogen receptor (ER)-positive BC accounts for majority of newly diagnosed cases, endocrine therapy is advised utilize either tamoxifen (Tam) or aromatase inhibitors. The use Tam as a monotherapy conjunction with an inhibitor following two three years has long been recommended. When used adjuvantly, medication reduces mortality and relapses, while it extends survival times metastatic when other treatments....