A5103146759- Alzheimer's disease research and treatments
- Mitochondrial Function and Pathology
- Lipid Membrane Structure and Behavior
- Cellular transport and secretion
- Parkinson's Disease Mechanisms and Treatments
- Enzyme Production and Characterization
- Botanical Research and Applications
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Macrophage Migration Inhibitory Factor
- Endoplasmic Reticulum Stress and Disease
- Microbial Metabolism and Applications
- Seaweed-derived Bioactive Compounds
- Tryptophan and brain disorders
University of Malta
2013-2021
Aggregation of the amyloid-forming α-synuclein (αS) protein is closely associated with etiology Parkinson's disease (PD), most common motor neurodegenerative disorder. Many studies have shown that soluble aggregation intermediates αS, termed oligomers, permeabilize a variety phospholipid membranes; thus, membrane disruption may represent key pathogenic mechanism αS toxicity. Given centrality mitochondrial dysfunction in PD, we therefore probed formation ion-permeable pores by oligomers...
Abstract Studies on the amyloidogenic N-terminal domain of E. coli HypF protein (HypF-N) have contributed significantly to a detailed understanding pathogenic mechanisms in neurodegenerative diseases characterised by formation misfolded oligomers, proteins such as amyloid-β, α-synuclein and tau. Given that both cell membranes mitochondria are increasingly recognised key targets oligomer toxicity, we investigated damaging effects aggregates HypF-N mitochondrial membranes. Essentially, found...
The identification of compounds which protect the double-membrane mitochondrial organelles from disruption by toxic confomers amyloid proteins may offer a therapeutic strategy to combat human neurodegenerative diseases. Here, we exploited an extract marine brown seaweed Padina pavonica (PPE) as vital source natural bioactive membranes against insult oligomeric aggregates amyloidogenic amyloid-β (Aβ), α-synuclein (α-syn) and tau, are currently considered be major targets for drug discovery in...