A5090328042- Glioma Diagnosis and Treatment
- Circular RNAs in diseases
- Cerebrospinal fluid and hydrocephalus
- Global Health and Surgery
- Neuroblastoma Research and Treatments
- Chromatin Remodeling and Cancer
- Epigenetics and DNA Methylation
- Spinal Fractures and Fixation Techniques
- Spinal Dysraphism and Malformations
- Childhood Cancer Survivors' Quality of Life
- MicroRNA in disease regulation
- Congenital Anomalies and Fetal Surgery
- Pelvic and Acetabular Injuries
- Ear Surgery and Otitis Media
- Acute Ischemic Stroke Management
- Radiomics and Machine Learning in Medical Imaging
- Pituitary Gland Disorders and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Reconstructive Facial Surgery Techniques
- ATP Synthase and ATPases Research
- Cleft Lip and Palate Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurogenesis and neuroplasticity mechanisms
- Folate and B Vitamins Research
- Cancer, Hypoxia, and Metabolism
University of Tennessee Health Science Center
2022-2024
St. Jude Children's Research Hospital
2018-2024
Semmes Murphey Foundation
2024
University of Tennessee at Knoxville
2024
Rhabdomyosarcoma is the most common soft-tissue sarcoma in childhood and histologically resembles developing skeletal muscle. Alveolar rhabdomyosarcoma (ARMS) an aggressive subtype with a higher rate of metastasis poorer prognosis. The majority ARMS tumors (80%) harbor PAX3-FOXO1 or less commonly PAX7-FOXO1 fusion gene. presence either gene foretells prognosis resulting clinical re-classification as fusion-positive (FP-RMS) fusion-negative RMS (FN-RMS). PAX3/7-FOXO1 genes result production...
PURPOSE Efforts to address inequities in the treatment of pediatric CNS tumors and burden childhood cancer globally have prompted designation low-grade glioma as one six index cancers for World Health Organization Global Initiative Childhood Cancer. Understanding importance neurosurgical interventions evaluating capacity may identify critical improve outcomes children with other tumors. METHODS An online, cross-sectional survey assessing practice was distributed members International Society...
Abstract Background Pediatric-type diffuse high-grade glioma (pHGG) is the most frequent malignant brain tumor in children and can be subclassified into multiple entities. Fusion genes activating MET receptor tyrosine kinase often occur infant-type hemispheric (IHG) but also other pHGG are associated with devastating morbidity mortality. Methods To identify new treatment options, we established characterized two novel orthotopic mouse models harboring distinct fusions. These included an...
Introduction: Defects in the tegmen tympani can result cerebrospinal fluid leaks with or without encephaloceles, a variety of etiologies and presenting symptoms. Operative repair typically involves obliteration meningocele, as well dural bony defect repair. Several methods have been described small series patients short-term follow-up.
Abstract BACKGROUND Diffuse hemispheric glioma (DHG), H3 G34-mutant, is a rare, aggressive brain tumor molecularly defined by mutations in the H3-3A gene. Our study explored association between patient outcomes and key molecular findings, resection extent, temozolomide (TMZ) use. METHODS Multi-institutional chart analysis of 32 patients with G34-mutant DHG. RESULTS The median age was 14 (10-28 years), M/F ratio 1.4. 1-year, 2-year, 5-year PFS were 40.4% (23.7%, 57.1%), 22.1% (9.0%, 38.7%),...
<title>Abstract</title> Background: H3 G34-mutant diffuse hemispheric glioma (DHG) is an aggressive tumor with a poor prognosis. We investigated the relationship between patient outcomes and molecular characteristics, extent of resection, temozolomide (TMZ) use. Additionally, we reviewed patterns treatment failure. Methods: Retrospective multi-institutional review clinical, imaging, characteristics 38 patients newly diagnosed DHG, supplemented by meta-analysis. Results: The median age was 14...
BACKGROUND AND OBJECTIVES: The management of blunt cerebrovascular injuries (BCVIs) remains an important topic within trauma and neurosurgery today. There a lack consensus the literature significant variation across institutions. purpose this study was to evaluate BCVI at large, tertiary referral center. METHODS: Institutional Review Board approval obtained conduct retrospective review patients with our Level 1 Trauma Center. Computed tomography angiography used identify for each patient....
Introduction: Lateral spondyloptosis of the lumbar spine is a rare and devastating form traumatic spinal injury. Given paucity lateral case reports in literature, authors seek to inform readers clinical, radiological, operative considerations for three patients with this uncommon clinical presentation, as well provide comprehensive review literature on topic. Methods: A retrospective chart admitted Regional One Health Elvis Presley Memorial Trauma Center Memphis, TN, over three-year period...
Abstract Pediatric-type diffuse high-grade gliomas are fatal central nervous system malignancies of childhood. Recurrent mutations in histone H3.3 at amino acid 34 (glycine to arginine/valine) a defining molecular feature hemispheric glioma, H3 G34-mutant (H3 DHG), which arises preferentially adolescents and young adults. Single-nuclei sequencing age anatomically matched wild-type primary patient tumors identified aberrant neuronal-like transcriptional programs enriched for signatures...
Abstract Purpose Length of stay (LOS) is a critical metric healthcare delivery. Prolonged LOS associated with heightened risk adverse complications. We aimed to provide comprehensive evaluation LOS, specifically identifying variables extended (eLOS), in children and young adults following elective craniotomy for tumor resection. Methods All craniotomies resection performed at our tertiary care children’s hospital from January 2010 December 2022 were included review, excluding patients >...
Background: Cushing's disease is a commonly described although not encountered pathology in which an excess of adrenocorticotropic hormone (ACTH) produced by functional pituitary adenoma, resulting hypersecretion cortisol the adrenal glands.[1] [2] [3] Pituitary apoplexy even less common that occurs due to acute hemorrhage or infarct adenomas, more nonfunctional adenomas.[2] Very rarely do these uncommon pathologies occur simultaneously same patient. When managed surgically, typically...
Abstract Pediatric diffuse high-grade gliomas (HGGs) are a heterogeneous spectrum of disease with abysmal survival rates. Approximately half in children arise midline structures predominantly the brainstem, but also thalamus, cerebellum and spinal cord. 80% these tumors harbor H3 K27M mutations, which result dramatic depletion post-translational modification H3K27me3. Alternative mutations can similar reduction H3K27me3, leading to redefined classification this collection as glioma,...