A5084133419- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Drug-Induced Hepatotoxicity and Protection
- Neuroscience and Neuropharmacology Research
- Phytochemistry and Bioactive Compounds
- Immune cells in cancer
- Liver Disease Diagnosis and Treatment
- Phytochemistry and Biological Activities
- Epilepsy research and treatment
- Melanoma and MAPK Pathways
- Phytochemistry Medicinal Plant Applications
- Diet and metabolism studies
- Cholinesterase and Neurodegenerative Diseases
- Phytochemical Studies and Bioactivities
- Diet, Metabolism, and Disease
- Natural Compound Pharmacology Studies
University of Oklahoma Health Sciences Center
2023-2025
Central University
2018
Abstract Background Microglia, the brain’s principal immune cells, have been implicated in pathogenesis of Alzheimer’s disease (AD), a condition shown to affect more females than males. Although sex differences microglial function and transcriptomic programming described across development models AD, no studies comprehensively identified divergences that emerge aging mouse hippocampus. Further, existing AD generally develop pathology (amyloid plaques tau tangles) early life fail recapitulate...
Metabolic dysfunction-associated steatohepatitis (MASH) is an advanced form of metabolic steatotic liver disease (MASLD) characterized by accumulation fats in liver, chronic inflammation, hepatocytic ballooning, and fibrosis. This study investigates the significance hepatic Aryl hydrocarbon Receptor (AhR) signaling cinnabarinic acid (CA)-mediated protection against MASH. Here, we report that livers high-fat, high-fructose, high-cholesterol diet-fed hepatocyte-specific knockout mice (AhR-hKO)...
Introduction . The stem bark extract of Maerua angolensis DC. (Capparaceae) is used as a traditional remedy for management anxiety, psychosis, and epilepsy. Aim the Study We therefore aimed at evaluating anxiolytic antidepressant potential plant in mice models. Methods dried was extracted with petroleum ether/ethyl acetate (50:50) mixture to obtain extract, MAE. employed Irwin’s test identify preliminary behavioral autonomic effects. Subsequently, MAE administered per os male subsequently...
Introduction. The stem bark of Maerua angolensis DC. (Capparaceae) is traditionally used for management epilepsy. Our aim was to evaluate the antiseizure potential and identify possible mechanisms by which effects are registered. Methods. petroleum ether/ethyl acetate extract (100–1000 mg kg −1 ) administered per os male Sprague-Dawley rats after pretreatment with flumazenil (0.3 or L-arginine (150 sildenafil (5 they subsequently received a subcutaneous injection pentylenetetrazole (65 )....
Maerua angolensis has been used traditionally in the management of pain, arthritis, and rheumatism Ghana Nigeria but no scientific evidence is currently available to give credence its folkloric use. The aim this study was therefore evaluate anti-inflammatory effects a stem bark extract DC (MAE) acute inflammatory models. MAE (30-300 mg kg −1 ) on neutrophil infiltration, exudate volume, endogenous antioxidant enzymes lung tissues morphology were evaluated with carrageenan induced pleurisy...
Microglia, the brain's principal immune cells, have been implicated in pathogenesis of Alzheimer's disease (AD), a condition shown to affect more females than males. Although sex differences microglial function and transcriptomic programming described across development models AD, no studies comprehensively identified divergences that emerge aging mouse hippocampus. Further, existing AD generally develop pathology (amyloid plaques tau tangles) early life fail recapitulate aged brain...