A5093674083- Breastfeeding Practices and Influences
- Epigenetics and DNA Methylation
- Maternal Mental Health During Pregnancy and Postpartum
- Craniofacial Disorders and Treatments
- Maternal and Perinatal Health Interventions
- Cleft Lip and Palate Research
University School
2024
Case Western Reserve University
2024
University of Wisconsin–Madison
2024
Cleveland Clinic Lerner College of Medicine
2024
Community Link
2024
Orofacial clefts of the lip and palate are widely recognized to result from complex gene–environment interactions, but inadequate understanding environmental risk factors has stymied development prevention strategies. We interrogated role DNA methylation, an environmentally malleable epigenetic mechanism, in orofacial development. Expression key methyltransferase enzyme DNMT1 was detected throughout morphogenesis epithelium underlying cranial neural crest cell (cNCC) mesenchyme, a highly...