A5017160404- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Single-cell and spatial transcriptomics
- Receptor Mechanisms and Signaling
- Dialysis and Renal Disease Management
- Acute Ischemic Stroke Management
- Genetics and Neurodevelopmental Disorders
- Neural dynamics and brain function
- Epilepsy research and treatment
- Advanced Memory and Neural Computing
- Neurological and metabolic disorders
- Mitochondrial Function and Pathology
- Shoulder Injury and Treatment
- Chronic Kidney Disease and Diabetes
- Trauma Management and Diagnosis
- Shoulder and Clavicle Injuries
- Neuroscience and Neural Engineering
- Tryptophan and brain disorders
- Cardiac electrophysiology and arrhythmias
- ATP Synthase and ATPases Research
- Schizophrenia research and treatment
- Metabolism and Genetic Disorders
University of Michigan–Ann Arbor
2017-2023
New York University
2017-2023
NYU Langone Health
2017-2020
Marine Biological Laboratory
2017-2019
State University of New York
2017
SUNY Downstate Health Sciences University
2012-2017
Chang Bing Show Chwan Memorial Hospital
2017
Shinko Hospital
2008
Phencyclidine (PCP) causes psychosis, is abused with increasing frequency, and was extensively used in antipsychotic drug discovery. PCP discoordinates hippocampal ensemble action potential discharge impairs cognitive control rats, but how this uncompetitive NMDA receptor (NMDAR) antagonist cognition remains unknown.
Objectives DEPDC5 is a common causative gene in familial focal epilepsy with or without malformations of cortical development. Its pathogenic variants also confer significantly higher risk for sudden unexpected death (SUDEP), providing opportunities to investigate the pathophysiology intersecting neurodevelopment, epilepsy, and cardiorespiratory function. There an urgent need gain mechanistic understanding DEPDC5‐related SUDEP, identify biomarkers patients at high risk, develop preventive...
Summary Objectives Focal cortical dysplasia type II (FCDII) is one of the most common underlying pathologies in patients with drug‐resistant epilepsy. However, mechanistic understanding FCDII fails to keep pace genetic discoveries, primarily due significant challenge developing a clinically relevant animal model. Conceptually and important questions, such as unknown latent period epileptogenesis controversial epileptogenic zone, remain all experimental models, making it even more challenging...
DEPDC5, the key gene within mechanistic target of rapamycin (mTOR) pathway, is one most common causative genes in patients with epilepsy and malformation cortical development (MCD). Although somatic mutations dorsal progenitors generate malformed cortex, its pathogenesis hyperexcitability complex remains unclear. We specifically deleted Depdc5 mouse forebrain to model DEPDC5-related investigated whether how parvalbumin interneurons were non-cell autonomously affected cortex. showed that long...
Abstract Single‐neuron gene expression studies may be especially important for understanding nervous system structure and function because of the neuron‐specific functionality plasticity that defines functional neural circuits. Cellular dissociation is a prerequisite technical manipulation single‐cell single cell‐population studies, but extent to which cellular process affects has not been determined. This information necessary interpreting results experimental manipulations affect such as...
GBM is the most life-threatening neurological disease with annual incidence of ∼ 5 cases per 100,000 people and a median survival less than 15 months. Seizures are first clinical symptoms in 40%-45% patients its epileptogenic mechanisms poorly understood, largely due to challenge develop clinically-relevant animal model unknown latent period. In this study, we used continuous video-EEG monitoring detect earliest interictal ictal events CRISPR- IUE rat that shares pathological features those...
Abstract The hippocampus plays a critical role in storing and retrieving spatial information. By targeting the dorsal manipulating specific “candidate” molecules using pharmacological genetic manipulations, we have previously discovered that long-term active place avoidance memory requires transient activation of particular hippocampus. These include amongst others, persistent kinases Ca-calmodulin kinase II (CaMKII) atypical protein C isoform PKC ι/λ for acquisition conditioned behavior,...
ABSTRACT We used the psychotomimetic phencyclidine (PCP) to investigate relationships between cognitive behavior, coordinated neural network function and information processing within hippocampus place cell system. report in rats that PCP (5mg/kg i.p.) impairs a well-learned hippocampus-dependent avoidance behavior requires control, even when is injected directly into dorsal hippocampus. increases 60-100 Hz medium gamma oscillations CA1 these correlate with impairment caused by systemic...
Abstract Single-neuron gene expression studies may be especially important for understanding nervous system structure and function because of the neuron-specific functionality plasticity that defines functional neural circuits. Cellular dissociation is a prerequisite technical manipulation single-cell single cell-population studies, but extent to which cellular process affects has not been determined. This information necessary interpreting results experimental manipulations affect such as...
ABSTRACT Background Phencyclidine (PCP) causes psychosis, is abused with increasing frequency, and was extensively used in antipsychotic drug discovery. PCP discoordinates hippocampal ensemble action potential discharge impairs cognitive control rats, but how this uncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist cognition remains unknown. Methods The effects of were investigated i) on CA1 vivo urethane-anesthetized rats during awake behavior mice; ii) synaptic responses ex...