Introduction . CYP2D6 is involved in the metabolism of tamsulosin, which used to treat lower urinary tract symptoms (LUTS) benign prostatic hyperplasia (BPH). However, impact carrying polymorphic variants gene on clinical efficacy and safety tamsulosin therapy still not well understood. Aim. To evaluate steady state concentration (Css min ), as their correlation with patients BPH. Materials methods A single-center prospective study included 75 who completed all stages study. The median age...

The clinical outcomes of tamsulosin therapy for LUTS/BPH patients vary, with up to one-third reporting unsatisfactory results. Enhancing the effectiveness and safety remains a significant challenge in current medical practice. Limited data exists regarding impact CYP2D6 genetic polymorphisms on efficacy therapy. Given that is metabolized by CYP2D6, variations this enzyme may influence drug's pharmacodynamic response. objective study was evaluate pharmacogenetic markers LUTS associated BPH....

Introduction. There is a dearth of literature comparing the three modalities partial nephrectomy – open, laparoscopic, and robotic based on two contemporary criteria, “trifecta” “pentafecta”. This scarcity justifies significance this study. Objective. To conduct comparative evaluation outcomes methods nephrectomy, assessed against criteria Materials & Methods. The prospective study included 600 patients with renal cell cancer from 2018 to 2022. was performed using open (200 patients),...

Tamsulosin is a first-line drug in the treatment of lower urinary tract symptoms (LUTS) benign prostatic hyperplasia (BPH). Despite high estimates its efficacy and safety, it rates may vary due to genetic polymorphisms genes for enzymes involved drugs metabolism. The aim work was evaluate carriage influence CYP3A group tamsulosin metabolizers on safety therapy patients with LUTS BPH. Materials methods. A total 142 LUTS, an established BPH diagnosis (N40 according ICD-10) were included study...

Tamsulosin is a first-line drug for the treatment of lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). Despite its high ratings efficacy and safety, these parameters may vary due to genetic polymorphisms CYP2D6 enzyme, which involved in metabolism drug. This variability have great impact on therapy LUTS BPH require an individualized approach selection. The aim study was assess safety tamsulosin patients BPH.

The article presents an analysis of the treatment results 1122 patients with pyelonephritis in pregnancy at different gestational periods (from 6 to 39-40 weeks pregnancy). age was from 16 41 years, average 26.15 ± 7 years. indications and methods urinary tract drainage pregnant women were analyzed depending on causes urodynamic disturbances (kidney stone disease, decreased tone, ureters compression by uterus, vesico-urethral reflux) term; stage (serous/ purulent). Errors patients’...

Objective: to determine the efficacy and safety of an integrated strategy aimed at preventing delayed renal graft function (DGF). Materials methods . From June 2018 December 2022, 478 deceased-donor kidney transplants were performed Botkin Hospital, Moscow. The patients divided into two groups: Group I consisted 128 who did not use strategy; II included 67 in whom DGF prevention was used perioperative stage. involved hypothermic oxygenated machine perfusion (HOPE) using expanded criteria...

To determine the role of human papillomavirus (HPV) high oncogenic risk in development urinary bladder cancer.100 patients (72 men and 28 women) aged 38 to 90 years (mean age 65+/-10 years) diagnosed with cancer were examined underwent treatment. Clinical assessment was complemented by enzyme-linked immunosorbent assays for presence antiviral antibodies herpes simplex virus (HSV) type 1 2, cytomegalovirus (CMV), Epstein-Barr (EBV), urethra scraping detecting HPV. Tumor tissue sampled PCR...

Background. Viral infection is a major factor in virus-associated carcinogenesis. Objective: to evaluate the expression of growth factors and markers apoptosis, proliferative activity, angiogenesis patients with viral DNA-positive bladder cancer. Materials methods. The study included 100 cancer (72 males 28 females) aged between 38 90 years (mean age 65 ± 10). Tumor tissue samples were tested by polymerase chain reaction detect DNA herpes simplex virus types 1 2 (HSV-1 HSV-2 respectively),...

Abstract The study demonstrates the ability of fluorescence diagnosis to perform intraoperative analysis bladder wall. data 10 patients with superficial cancer who underwent PDD use video system excitation wavelenght in “red” wavelength range and TUR is discussed. General condition assessed, main foci tumor are determined. Then a resection performed. Further examination identification fluorescing boundaries remaining after performed make decision re‐resection. In addition, small foci, not...

Background. Renal stones of ≤ 2cm size occur most commonly, with several treatment options currently available that include remote shockwave lithotripsy, percutaneous nephrolithotripsy (PCNL) and retrograde intrarenal surgery (RIRS). The choice for 2 cm kidney remains a relevant hotly debated issue. Aim. A study the efficacy, safety, advantages disadvantages ultra-mini (ultra-mini PCNL) (RIRS) in stones. Materials methods. Treatment outcomes urology patients Botkin Hospital were analysed...

Introduction. Research on the treatment of patients with a combination anterior urethral stricture and benign prostatic hyperplasia (BPH) is basically absent in worldwide literature. Objective. To analyse primary experience results simultaneous BPH. Materials & methods. The study included four BPH, who underwent surgical including perineal / penile urethrostomy thulium laser enucleation prostate. success criterion for was considered to be absence obstructive lower urinary tract symptoms...

Introduction. Implantation of an artificial urinary sphincter (AUS) is the main treatment method for patients with intrinsic sphincteric deficiency. There are few studies investigating effectiveness, safety, and impact on quality life AUS implantation beyond a ten-year follow-up. Objective. To evaluate outcomes in terms efficacy, group Materials & methods. From 2004 to 2023, were implanted 62 severe stress incontinence, whom 14 had follow-up period more than 10 years. Urine loss...

Introduction. Th e surgical margin status and pathological tumor stage constitute important factors affecting recurrence after partial nephrectomy. Aim. To assess the role of in open Materials methods. retrospective study included 904 kidney cancer patients who underwent nephrectomy from 2010 to 2019. Results. Renal cell carcinoma was found 796 (88.1 %) patients. A negative detected 735 (92.3 cases. Pathological stages were distributed as follows: pT1aN0M0 — 530 (66.6 %); pT1bN0M0 239 (30.0...

Objective: to improve the outcomes of liver transplantation (LTx) from expanded criteria donors (ECDs) through hypothermic oxygenated machine perfusion (HOPE). Material and methods. The study included 63 cases LTx suboptimal brain-dead donors. Group I (control) consisted 34 persons in which transplant was preserved only by static cold storage (SCS), while group II (main) comprised 29 where ex situ HOPE used after preservation. We evaluated efficacy safety latter a comparative clinical...

The existing criteria of acute kidney injury assessment fail to identify parenchyma damage small severity and predict long-term outcomes its resection. aim the research was assess percentage reduction glomerular filtration rate as a marker for functional outcome one year after surgery

Background. A lot of techniques are utilized in order to improve functional results partial nephrectomy. Many questions regarding this issue remain controversial. Aim. To evaluate the influence various on Materials and methods. The retrospective study included 904 patients with renal cell carcinoma who underwent open nephrectomy between 2010 2019. were assessed according trifecta pentafecta criteria. effect following was assessed: a) enucleation tumor; b) coagulation bed without suture; c)...

The Manual presents the possibilities of using MAVIT device in combination treatment patients with benign prostatic hyperplasia. content is consistent higher education program for training highest qualification resident physicians and professional retraining (OD.A.03.2.3 Alternating Currents, Electric, Electromagnetic Magnetic Fields. High, Ultra-High Extra-High Frequency) specialty 31.08.50 “Physiotherapy” (B.1.B.1.4.5.1 “Physiotherapy Urology,” B.1.B.1.6.3.5. “Prostatitis”) 08/31/68...