A5087000819- Neurogenesis and neuroplasticity mechanisms
- Olfactory and Sensory Function Studies
- Proteoglycans and glycosaminoglycans research
- Caveolin-1 and cellular processes
- Congenital heart defects research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Neonatal and fetal brain pathology
- Vestibular and auditory disorders
- Neurological Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Mitochondrial Function and Pathology
McGill University
2020-2024
Douglas Mental Health University Institute
2020-2024
Abstract Child abuse (CA) is a strong predictor of psychopathologies and suicide, altering normal trajectories brain development in areas closely linked to emotional responses such as the prefrontal cortex (PFC). Yet, cellular underpinnings these enduring effects are unclear. Childhood adolescence marked by protracted formation perineuronal nets (PNNs), which orchestrate closure developmental windows cortical plasticity regulating functional integration parvalbumin interneurons into neuronal...
During childhood and adolescence, the brain is highly responsive to external stimuli compared adulthood. Perineuronal nets (PNNs), play a crucial role during this period by reducing neuroplasticity. These mesh-like structures protect fortify neural connections between cells. Child abuse includes physical, emotional, sexual and/or neglect1. It consistently associated with negative mental physical health outcomes, underscoring importance of identifying risk resilience factors for effective...
Abstract Child abuse (CA) is a strong predictor of psychopathologies and suicide, altering normal trajectories brain development in areas closely linked to emotional responses such as the prefrontal cortex (PFC). Yet, cellular underpinnings these enduring effects are unclear. Childhood adolescence marked by protracted formation perineuronal nets (PNNs), which orchestrate closure developmental windows cortical plasticity regulating functional integration parvalbumin interneurons (PV) into...
Abstract Little is known about the morphological diversity and distribution of cerebellar astrocytes in human brain how or if these features differ from those species used to model illnesses. To address this, we performed a comparative post-mortem examination Purkinje cells (PCs) healthy humans, macaques, mice using microscopy-based techniques. Visualizing with canonical astrocyte markers glial fibrillary acidic protein (GFAP) aldehyde dehydrogenase-1 family member L1 (ALDH1L1), mapped...
Abstract The olfactory bulb (OB), a major structure of the limbic system, has been understudied in human investigations psychopathologies such as depression. To explore more directly molecular features OB depression, global comparative proteome analysis was carried out with post-mortem samples from 11 males having suffered depression and 12 healthy controls. We identified 188 differentially abundant proteins (with adjusted p<0.05) between depressed cases Gene ontology gene enrichment...