A5109281483- Sarcoidosis and Beryllium Toxicity Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Drug-Induced Adverse Reactions
- Environmental Science and Water Management
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- interferon and immune responses
- Bone and Joint Diseases
- RNA modifications and cancer
- RNA Research and Splicing
- Autoimmune and Inflammatory Disorders
- Total Knee Arthroplasty Outcomes
- Inflammasome and immune disorders
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Inhalation and Respiratory Drug Delivery
- Chemokine receptors and signaling
- Tuberculosis Research and Epidemiology
- Orthopaedic implants and arthroplasty
- Asthma and respiratory diseases
- Genomics and Chromatin Dynamics
- Inflammatory Biomarkers in Disease Prognosis
- IL-33, ST2, and ILC Pathways
- Bone Metabolism and Diseases
University Health Network
2015-2016
Toronto General Hospital
2016
University of Toronto
2016
Palacký University Olomouc
2010-2015
Charles University
2015
University Hospital Olomouc
2011
Czech Academy of Sciences, Institute of Molecular Genetics
2011
Institute of Molecular and Translational Medicine
2010-2011
Immunomedics (Germany)
2011
There is increasing evidence to suggest that splicing decisions are largely made when the nascent RNA still associated with chromatin. Here we demonstrate activity of histone deacetylases (HDACs) influences splice site selection. Using splicing-sensitive microarrays, identified ∼700 genes whose was altered after HDAC inhibition. We provided inhibition induced H4 acetylation and increased Polymerase II (Pol II) processivity along an alternatively spliced element. In addition, reduced...
Upregulation of genes for interferon (IFN)-γ and CXC chemokine receptor (CXCR)3 expression, two crucial molecules in sarcoid inflammation granuloma formation, is directly controlled by the T-helper (Th)1 transcription factor T-bet (T-box, expressed T-cells). However, there no information on expression sarcoidosis or its relationship with “sarcoidosis-associated” genes. Therefore, we investigated mRNA and, parallel, a spectrum known to be involved pathogenesis. Transcripts were determined...
Introduction: Patients with pulmonary and plus extrapulmonary sarcoidosis differ in symptom severity health status impairment. To date there is no information on differences clinical laboratory parameters between these phenotypes limited involvement Czech patients exists. Methods: We therefore compared data (age, gender, organ involvement, lung function tests) (blood counts, bronchoalveolar fluid (BAL) cellular profile, serum levels of CRP, SACE, sIL-2R, neopterin) newly diagnosed (n=107)...
XB130 is a novel oncoprotein that promotes cancer cell survival, proliferation and migration. Its physiological function in vivo largely unknown. The objective of this study was to determine the role lipopolysaccharide (LPS)-induced septic responses acute lung injury. LPS intraperitoneally administrated Xb130 knockout (KO) wild type (WT) mice. There significant weight loss KO mice at Day 2 significantly higher disease scores during 7 days observation. levels tumor necrosis factor-alpha,...