A5057741995- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- interferon and immune responses
- CRISPR and Genetic Engineering
- Sirtuins and Resveratrol in Medicine
- Cell death mechanisms and regulation
- Telomeres, Telomerase, and Senescence
- Immune cells in cancer
- Pharmacogenetics and Drug Metabolism
- BRCA gene mutations in cancer
- Inflammasome and immune disorders
- Inflammation biomarkers and pathways
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Ocular Oncology and Treatments
- Genomics and Rare Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Medicinal Plants and Neuroprotection
- Melanoma and MAPK Pathways
- Metabolism, Diabetes, and Cancer
- Cancer Genomics and Diagnostics
- Ubiquitin and proteasome pathways
- Immune Response and Inflammation
- Peptidase Inhibition and Analysis
The Maria Sklodowska-Curie National Research Institute of Oncology
2009-2024
PPM1D (WIP1) negatively regulates by dephosphorylation many proteins including p53 tumour suppressor. The truncating mutations (nonsense and frameshift) in exon 6 of were found recently blood cells patients with breast, ovarian or colorectal cancer. These mutants code for gain-of-function retained phosphatase activity. Their significance carcinogenesis is unknown. was sequenced DNA 543 non-small-cell lung cancer (NSCLC). functional selected alterations (Arg458X, Lys469Glu) compared the...
Co-treatment with actinomycin D and nutlin-3a (A + N) strongly activates p53. Previously we reported that CHIR-98014 (GSK-3 kinase inhibitor), acting in cells exposed to A N, prevents activation of TREM2-an innate immunity p53-regulated gene associated Alzheimer's disease. In order find novel candidate p53-target genes regulated by CHIR-98014, performed RNA-Seq control A549 the N or CHIR-98014. We validated data for selected using RT-PCR and/or Western blotting. Using CRISPR/Cas9 technology...
We studied the associations between 3'UTR genetic variants in ADME genes, clinical factors, and risk of breast cancer chemotherapy toxicity. Those factors were tested relation to seven symptoms belonging myelotoxicity (anemia, leukopenia, neutropenia), gastrointestinal side effects (vomiting, nausea), nephrotoxicity, hepatotoxicity, occurring overall, early, or recurrent settings. The cumulative overall anemia was connected with
Resveratrol is a natural compound that has been intensely studied due to its role in cancer prevention and potential as an anti-cancer therapy. Its effects include induction of apoptosis senescence-like growth inhibition. Here, we report two cell lines (U-2 OS A549) differ significantly their molecular responses resveratrol. Specifically, U-2 cells, the activation p53 pathway attenuated when compared A549 cells. This attenuation accompanied by point mutation (458: CGA→TGA) PPM1D gene...
The unique oncogenic duo of BRAF and TERT promoter ( p) variants was demonstrated to be associated with aggressiveness poor prognosis in several different cancer types, including melanoma thyroid cancer. It has been shown that the coexistence p a significantly more substantial impact on clinical outcomes than presence mutated or alone. At same time, co-occurrence may also Achilles Heel cells context targeted therapies' effectiveness. This paper aims summarize data from tumors which...
The influence of <em>BRCA1/2</em> variants uncertain significance (VUSs) on the cancer risk and their association with response to treatment is uncertain. aim present study was evaluate role <em>BRCA</em> VUS in patients breast cancer. A total two cases were described. complete coding sequence genes analyzed from genomic DNA material by next generation sequencing Ion Torrent platform. presence c.3454G>A (p.Asp1152Asn) <em>BRCA1</em> gene reported a 64‑year‑old woman invasive carcinoma....