A5044356237- Analytical Methods in Pharmaceuticals
- Spectroscopy Techniques in Biomedical and Chemical Research
- Spectroscopy and Chemometric Analyses
- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Analytical Chemistry and Chromatography
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Phytochemistry and Biological Activities
- Drug Transport and Resistance Mechanisms
- Pesticide Residue Analysis and Safety
- Probiotics and Fermented Foods
- Bioactive natural compounds
- Pharmacy and Medical Practices
- Oral microbiology and periodontitis research
- Natural product bioactivities and synthesis
- Pharmaceutical industry and healthcare
- Oral and gingival health research
Islamia University of Bahawalpur
2019-2021
Center for Drug Evaluation and Research
2015-2018
Centre National de la Recherche Scientifique
2017
Centre de Biophysique Moléculaire
2017
Quality Research
2015
P-glycoprotein (P-gP) efflux-mediated multidrug resistance is a fundamental aspect of chemotherapeutic failure in oncology. The current study aims to deliver paclitaxel (PTX) specifically at the target site with improved vivo efficacy poorly permeable PTX against solid tumors. Multifunctional polymeric micelles as targeted delivery have been devised for loading and release PTX. Mucoadhesion, permeation enhancement, oral pharmacokinetics, biodistribution, toxicological studies were carried...
Monitoring of the physical state warfarin sodium (WS) in products is essential for minimizing product quality variability order to ensure consistent clinical performance. This study reports development chemometric models quantifying crystalline and amorphous fractions WS commercial drug using NIR spectroscopy. Formulations based on commercially available with different API excipient ratio were used study. For each content, two formulations containing either lactose monohydrate or anhydrous...
Abstract Coumadin® a nd s everal generic products of warfarin odium (WS) contain the crystalline form (clathrate) in which WS and isopropanol (IPA) are associated 2:1 molar ratio. IPA is critical maintaining structure. Physicochemical properties drug product may change when transforms to amorphous form. A headspace-gas chromatography (HS-GC) method was developed validated for determination product. n-propanol (NPA) used as internal standard specificity, system suitability, linearity,...