A5046179989- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Developmental Biology and Gene Regulation
- Amphibian and Reptile Biology
- Chromosomal and Genetic Variations
- Genomics and Chromatin Dynamics
- Congenital heart defects research
- Genomics and Phylogenetic Studies
- Cancer-related molecular mechanisms research
- Congenital Ear and Nasal Anomalies
- Plant Reproductive Biology
- Cancer-related gene regulation
- Neurobiology and Insect Physiology Research
- Bone fractures and treatments
- Animal Genetics and Reproduction
- Transgenic Plants and Applications
- Single-cell and spatial transcriptomics
- Morphological variations and asymmetry
- Hip disorders and treatments
- Orthopaedic implants and arthroplasty
- Turtle Biology and Conservation
- Silk-based biomaterials and applications
- Urologic and reproductive health conditions
- thermodynamics and calorimetric analyses
- Evolution and Genetic Dynamics
- Cephalopods and Marine Biology
University of Colorado Denver
2019-2022
Zamorano Pan-American Agricultural School
2019
Creative Commons
2019
Hospital Clínico de la Universidad de Chile
2019
University of Georgia
2011-2018
University of Arizona
2017-2018
Harvard University
2008-2013
Birds display remarkable diversity in the distribution and morphology of scales feathers on their feet, yet genetic developmental mechanisms governing this remain unknown. Domestic pigeons have striking variation foot feathering within a single species, providing tractable model to investigate molecular basis skin appendage differences. We found that feathered feet result from partial transformation hindlimb forelimb identity mediated by cis-regulatory changes genes encoding...
Vertebrate pelvic reduction is a classic example of repeated evolution. Recurrent loss appendages in sticklebacks has previously been linked to natural mutations enhancer that maps upstream Pitx1. The sequence this PelA not conserved mammals, so we have surveyed large region surrounding the mouse Pitx1 gene for other possible hind limb control sequences. Here identify new enhancer, PelB, downstream rather than PelB drives expression posterior portion developing limb, and deleting from mice...
Rapid technological improvements are democratizing access to high quality, chromosome-scale genome assemblies. No longer the domain of only most highly studied model organisms, now non-traditional and emerging species can be genome-enabled using a combination sequencing technologies assembly software. Consequently, old ideas built on sparse sampling across tree life have recently been amended in face genomic data drawn from growing number high-quality reference genomes. Arguably valuable...
Squamates include all lizards and snakes, display some of the most diverse extreme morphological adaptations among vertebrates. However, compared with birds mammals, relatively few resources exist for comparative genomic analyses squamates, hampering efforts to understand molecular bases phenotypic diversification in such a speciose clade. In particular, ∼400 species anole lizard represent an extensive squamate radiation. Here, we sequence assemble draft genomes three species-Anolis...
SUMMARY Phenotypic variation is a prerequisite for evolution by natural selection, yet the processes that give rise to novel morphologies upon which selection acts are poorly understood. We employed chemical genetic screen identify developmental changes capable of generating ecologically relevant morphological as observed among extant species. Specifically, we assayed exogenously applied small molecules transforming ancestral larval foregut herbivorous Xenopus laevis resemble derived...
Genital malformations are among the most common human birth defects, and both genetic environmental factors can contribute to these malformations. Development of external genitalia in mammals relies on complex signaling networks, disruption pathways lead genital defects. Islet-1 (ISL1), a member LIM/Homeobox family transcription factors, has been identified as major susceptibility gene for classic bladder exstrophy humans, form exstrophy-epispadias (BEEC), is implicated role urinary tract...
The tetrapod limb is a stunning example of evolutionary diversity, with dramatic variation not only among distantly related species, but also between the serially homologous forelimbs (FLs) and hindlimbs (HLs) within species. Despite this variation, highly conserved genetic developmental programs underlie development identity in all tetrapods, raising question how diversification generated from toolkit. In some breeds domestic pigeon, shifts expression two transcription factors, PITX1 TBX5,...
Abstract Ziermann, J.M., Infante, C., Hanken, J. and Olsson, L. 2011. Morphology of the cranial skeleton musculature in obligate carnivorous tadpole Lepidobatrachus laevis (Anura: Ceratophryidae). — Acta Zoologica (Stockholm) 00 :1–12. (Ceratophryidae: Ceratophryinae) is a bizarre frog endemic to Chacoan desert central South America. Its an carnivore that can catch consume live prey nearly its own size. Morphological adaptations associated with this unique feeding mode, including larval...
ABSTRACT Anolis lizards are an emerging model system for the study of limb development and evolution, but very little is known concerning regulatory interactions that control patterning differences among species or what deeply conserved between other tetrapod groups. Here we report establishment embryonic micromass culture enables functional studies forelimb hindlimb gene networks in . Characterization this demonstrated micromasses from different easy to sustain weeks, expression...
Abstract Rapid technological improvements are democratizing access to high quality, chromosome-scale genome assemblies. No longer the domain of only most highly studied model organisms, now non-traditional and emerging species can be genome-enabled using a combination sequencing technologies assembly software. Consequently, old ideas built on sparse sampling across tree life have recently been amended in face genomic data drawn from growing number high-quality reference genomes. Arguably...
Purpose: To analyze the torsion of lower extremities in a healthy cohort and to determine contribution different segments femur tibia both bones. Methods: In this cross-sectional study, 32 patients with nonjoint or bone-related symptoms were analyzed by CT angiography. Lower-limb torsion, femoral proximal shaft distal tibial measured. Results: The median total limb was 25° external being −9° 30°. Both metaphyses had internal metaphysis approximately three times greater than that metaphysis....
Abstract The tetrapod limb is a stunning example of evolutionary diversity, with dramatic variation not only among distantly related species, but also between the serially homologous forelimbs (FLs) and hindlimbs (HLs) within species. Despite this variation, highly conserved genetic developmental programs underlie development identity in all tetrapods, raising question how diversification generated from toolkit. In some breeds domestic pigeon, shifts expression two transcription factors,...
Phenotypic variation is a prerequisite for evolution by natural selection, yet the processes that give rise to novel morphologies upon which selection acts are poorly understood. We employed chemical genetic screen identify developmental changes capable of generating morphological as observed among extant species. Specifically, we assayed small molecules transforming ancestral larval foregut herbivorous Xenopus laevis resemble derived carnivorous Lepidobatrachus . Appropriately, demonstrate...