A5025346243- Immune Cell Function and Interaction
- Immune Response and Inflammation
- HIV Research and Treatment
- Ovarian function and disorders
- Adipokines, Inflammation, and Metabolic Diseases
- T-cell and Retrovirus Studies
- Sepsis Diagnosis and Treatment
- Reproductive Biology and Fertility
- Pharmacology and Obesity Treatment
- Dietary Effects on Health
- Lipid metabolism and disorders
- Systemic Sclerosis and Related Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Acute Kidney Injury Research
- Hormonal and reproductive studies
- Antimicrobial Peptides and Activities
- HIV-related health complications and treatments
- Inflammation biomarkers and pathways
- Diabetes and associated disorders
- Intensive Care Unit Cognitive Disorders
- Antioxidant Activity and Oxidative Stress
- T-cell and B-cell Immunology
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Cardiac Ischemia and Reperfusion
Universidad de Alcalá
2013-2020
Instituto Ramón y Cajal de Investigación Sanitaria
2015-2020
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2015-2020
Hospital Universitario Ramón y Cajal
2015-2020
Centro de Ingeniería Genética y Biotecnología
1996-2013
We studied if macronutrients of the diet have different effects on leukocyte activation, and these are influenced by sex hormones or obesity. analyzed cell surface gene expression toll-like receptors 2 4 (TLR2 TLR4) during fasting after macronutrient loads in women with polycystic ovary syndrome female male controls. Fasting TLR2 neutrophils was higher men than women. Obese subjects presented nonobese individuals, particularly men. In contrast, TLR4 lower obese individuals. Postprandial...
Scope Oxidative stress and damage participate in the pathophysiology of obesity its metabolic complications. We studied influence sex, obesity, ingestion different macronutrients on fasting postprandial thiobarbituric acid reactive substances (TBARS), which can be considered as an index lipid peroxidation oxidative damage. Methods results 19 men 17 women, out whom nine eight women had obesity. collected blood samples state and, alternate days, following 300 kcal form glucose, lipids, or...
IL‐15 is a proinflammatory cytokine that acts early in the inflammatory response and has been associated with several autoimmune diseases including rheumatoid arthritis, where it had proposed as therapeutic target. We recently reported an antagonist peptide corresponding to sequence 36–45 of (KVTAMKCFLL) named P8, which specifically binds IL‐15R α inhibits biological activity half maximal inhibitory concentration (IC50) 130 µ m CTLL‐2 proliferation assay. In order improve binding P8 receptor...