A5040837264- Telomeres, Telomerase, and Senescence
- Lanthanide and Transition Metal Complexes
- Coral and Marine Ecosystems Studies
- Cancer Treatment and Pharmacology
- Ion Transport and Channel Regulation
- Genetics, Aging, and Longevity in Model Organisms
- Microplastics and Plastic Pollution
- Ion channel regulation and function
- bioluminescence and chemiluminescence research
- Molecular Sensors and Ion Detection
- Photoreceptor and optogenetics research
- Advanced biosensing and bioanalysis techniques
- Cannabis and Cannabinoid Research
- Marine and coastal ecosystems
- Renal and related cancers
- Heavy Metal Exposure and Toxicity
- Marine animal studies overview
- DNA Repair Mechanisms
- Microbial Community Ecology and Physiology
- Mesenchymal stem cell research
- Autophagy in Disease and Therapy
- Erythrocyte Function and Pathophysiology
- Geology and Paleoclimatology Research
- Oceanographic and Atmospheric Processes
- Muscle Physiology and Disorders
Institut de Recherche sur le Cancer et le Vieillissement de Nice
2014-2025
Inserm
2010-2025
Centre National de la Recherche Scientifique
2008-2025
Université Côte d'Azur
2010-2025
Scientific Centre of Monaco
2021
Faculty (United Kingdom)
2014
Institut de Recherche en Santé, Environnement et Travail
2010
Université de Rennes
2008-2010
Institut de Pharmacologie Moléculaire et Cellulaire
2009
Telomeric repeat binding factor 2 (TRF2), which plays a central role in telomere capping, is frequently increased human tumors. We reveal here that TRF2 expressed the vasculature of most cancer types, where it colocalizes with Wilms' tumor suppressor WT1. further show transcriptional target WT1 and required for proliferation, migration, tube formation endothelial cells. These angiogenic effects are uncoupled from its function capping. Instead, binds transactivates promoter tyrosine kinase...
Cisplatin is an antineoplastic drug, mostly documented to cause cell death through the formation of DNA adducts. In patients, it exhibits a range short-term side effects that are unlikely be related its genomic action. As cisplatin has been shown modify membrane properties in different systems, we investigated on mechanosensitive ion transporters and channels. We show here noncompetitive inhibitor Na(+)/H(+) exchanger NHE-1, with half-inhibition concentration 30 μg/mL associated decrease...
The stability of mammalian telomeres depends upon TRF2, which prevents inappropriate repair and checkpoint activation. By using a plasmid integration assay in yeasts carrying humanized telomeres, we demonstrated that TRF2 possesses the intrinsic property to both stimulate initial homologous recombination events prevent their resolution via its basic N-terminal domain. In human cells, further showed this domain telomere shortening mediated by resolvase-associated protein SLX4 as well GEN1...
Abstract While a rich history of patchiness research has explored spatial structure in the ocean, there is no consensus over controls on biological and how physical-ecological-biogeochemical processes relate. The prevailing thought that physics structures biology, but this not been tested at basin scale with consistent situ measurements. Here we use slope relationship between variance vs to quantify ~650,000 nearly continuous ( dx ~ 200 m) measurements - representing Atlantic, Pacific,...
Abstract Telomeres are environment-sensitive regulators of health and aging. Here,we present telomere DNA length analysis two reef-building coral genera revealing that the long- short-term water thermal regime is a key driver between-colony variation across Pacific Ocean. Notably, there differences between studied genera. The lengths short-lived, more stress-sensitive Pocillopora spp. colonies were largely determined by seasonal temperature variation, whereas those long-lived,...
NHE-1 is a ubiquitous, mitogen-activatable, mammalian Na+/H+ exchanger that maintains cytosolic pH and regulates cell volume. We have previously shown the kinetics of positive cooperative activation by intracellular acidifications fit best with Monod−Wyman−Changeux mechanism, in which dimeric oscillates between low- high-affinity conformation for protons. The ratio these two forms, allosteric equilibrium constant L0, favor low-affinity form, making system inactive at physiological pH....
Abstract Telomere DNA length is a complex trait controlled by both multiple loci and environmental factors. A growing number of studies are focusing on the impact stress accumulation telomere link with survival fitness in ecological contexts. Here, we investigated changes occurring symbiotic coral, Stylophora pistillata , that has experienced continuous darkness over 6 months. This condition led to loss its symbionts similar manner observed during large‐scale bleaching events due climate...
Cadmium toxicity remains a major public health concern, despite huge amount of work to explain its effects. The kidney is the most sensitive organ; and we recently provide first evidence direct upregulation autophagy by cadmium particularly in response environmental relevant concentrations. Investigation greatly progressed various strategies have been reported for studying this molecular process different biological systems both physiological stress conditions. Furthermore, mechanisms...
Supplementary Figures 1-4, Methods from Nongenomic Effects of Cisplatin: Acute Inhibition Mechanosensitive Transporters and Channels without Actin Remodeling
Supplementary Figures 1-4, Methods from Nongenomic Effects of Cisplatin: Acute Inhibition Mechanosensitive Transporters and Channels without Actin Remodeling
<div>Abstract<p>Cisplatin is an antineoplastic drug, mostly documented to cause cell death through the formation of DNA adducts. In patients, it exhibits a range short-term side effects that are unlikely be related its genomic action. As cisplatin has been shown modify membrane properties in different systems, we investigated on mechanosensitive ion transporters and channels. We show here noncompetitive inhibitor Na<sup>+</sup>/H<sup>+</sup> exchanger...
<div>Abstract<p>Cisplatin is an antineoplastic drug, mostly documented to cause cell death through the formation of DNA adducts. In patients, it exhibits a range short-term side effects that are unlikely be related its genomic action. As cisplatin has been shown modify membrane properties in different systems, we investigated on mechanosensitive ion transporters and channels. We show here noncompetitive inhibitor Na<sup>+</sup>/H<sup>+</sup> exchanger...
Telomere DNA length is a complex trait controlled both by multiple loci and environmental factors. Even though the use of telomere measurement, as method assessing stress accumulation predicting how this will influence survival, currently being studied in numerous human cohort studies, importance for response ecological studies remains at its infancy. Here, we investigated changes occurring symbiotic coral Stylophora pistillata that has experienced continuous darkness over six months. This...